Patents by Inventor Mark Pykett
Mark Pykett has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240100186Abstract: The present invention is directed to compositions and methods for treating aromatic L-amino acid decarboxylase (AADC) deficiency. This invention includes a method of treating AADC deficiency in a pediatric subject, comprising the steps of: (a) providing a pharmaceutical formulation comprising an rAAV2-hAADC vector, (b) stereotactically delivering the pharmaceutical formulation to at least one target site in the brain of the subject in a dose of an amount at least about 1.8×1011 vg; wherein delivering the pharmaceutical formulation to the brain is optionally by frameless stereotaxy, and optionally wherein the dose is an amount of at least about 2.4×1011 vg and in some embodiments wherein the pharmaceutical formulation comprises a rAAV2-hAADC vector concentration of about 5.7×1011 vg/mL.Type: ApplicationFiled: November 30, 2023Publication date: March 28, 2024Inventors: Mark Pykett, Richard Thorn, Wuh-Liang ("Paul") Hwu
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Patent number: 11865188Abstract: The present invention is directed to compositions and methods for treating aromatic L-amino acid decarboxylase (AADC) deficiency. This invention includes a method of treating AADC deficiency in a pediatric subject, comprising the steps of: (a) providing a pharmaceutical formulation comprising an rAAV2-hAADC vector, (b) stereotactically delivering the pharmaceutical formulation to at least one target site in the brain of the subject in a dose of an amount at least about 1.8×1011 vg; wherein delivering the pharmaceutical formulation to the brain is optionally by frameless stereotaxy, and optionally wherein the dose is an amount of at least about 2.4×1011 vg and in some embodiments wherein the pharmaceutical formulation comprises a rAAV2-hAADC vector concentration of about 5.7×1011 vg/mL.Type: GrantFiled: January 25, 2021Date of Patent: January 9, 2024Assignee: National Taiwan UniversityInventors: Mark Pykett, Richard Thorn, Wuh-Liang (“Paul”) Hwu
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Publication number: 20240000973Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.Type: ApplicationFiled: July 24, 2023Publication date: January 4, 2024Inventors: Stephen SCHAUER, Darby THOMAS, Gregory ROBINSON, Mark PYKETT, Richard THORN, Kirsten GRUIS
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Patent number: 11116852Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.Type: GrantFiled: November 8, 2017Date of Patent: September 14, 2021Assignee: PRECIGEN, INC.Inventors: Stephen Schauer, Darby Thomas, Gregory Robinson, Mark Pykett, Richard Thorn, Kirsten Gruis
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Publication number: 20210236653Abstract: The present invention is directed to compositions and methods for treating aromatic L-amino acid decarboxylase (AADC) deficiency. This invention includes a method of treating AADC deficiency in a pediatric subject, comprising the steps of: (a) providing a pharmaceutical formulation comprising an rAAV2-hAADC vector, (b) stereotactically delivering the pharmaceutical formulation to at least one target site in the brain of the subject in a dose of an amount at least about 1.8×1011 vg; wherein delivering the pharmaceutical formulation to the brain is optionally by frameless stereotaxy, and optionally wherein the dose is an amount of at least about 2.4×1011 vg and in some embodiments wherein the pharmaceutical formulation comprises a rAAV2-hAADC vector concentration of about 5.7×1011 vg/mL.Type: ApplicationFiled: January 25, 2021Publication date: August 5, 2021Inventors: Mark Pykett, Richard Thorn, Wuh-Liang ("Paul") Hwu
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Publication number: 20210177991Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.Type: ApplicationFiled: December 17, 2020Publication date: June 17, 2021Inventors: Stephen SCHAUER, Darby THOMAS, Gregory ROBINSON, Mark PYKETT, Richard THORN, Kirsten GRUIS
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Patent number: 10898585Abstract: The present invention is directed to compositions and methods for treating aromatic L-amino acid decarboxylase (AADC) deficiency. This invention includes a method of treating AADC deficiency in a pediatric subject, comprising the steps of: (a) providing a pharmaceutical formulation comprising an rAAV2-hAADC vector, (b) stereotactically delivering the pharmaceutical formulation to at least one target site in the brain of the subject in a dose of an amount at least about 1.8×1011 vg; wherein delivering the pharmaceutical formulation to the brain is optionally by frameless stereotaxy, and optionally wherein the dose is an amount of at least about 2.4×1011 vg and in some embodiments wherein the pharmaceutical formulation comprises a rAAV2-hAADC vector concentration of about 5.7×1011 vg/mL.Type: GrantFiled: April 12, 2018Date of Patent: January 26, 2021Assignees: PTC THERAPEUTICS .INC., NATIONAL TAIWAN UNIVERSTYInventors: Mark Pykett, Richard Thorn, Wuh-Liang (“Paul”) Hwu
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Publication number: 20190000991Abstract: The present invention is directed to compositions and methods for treating aromatic L-amino acid decarboxylase (AADC) deficiency. This invention includes a method of treating AADC deficiency in a pediatric subject, comprising the steps of: (a) providing a pharmaceutical formulation comprising an rAAV2-hAADC vector, (b) stereotactically delivering the pharmaceutical formulation to at least one target site in the brain of the subject in a dose of an amount at least about 1.8×1011 vg; wherein delivering the pharmaceutical formulation to the brain is optionally by frameless stereotaxy, and optionally wherein the dose is an amount of at least about 2.4×1011 vg and in some embodiments wherein the pharmaceutical formulation comprises a rAAV2-hAADC vector concentration of about 5.7×1011 vg/mL.Type: ApplicationFiled: April 12, 2018Publication date: January 3, 2019Inventors: Mark Pykett, Richard Thorn, Wuh-Liang ("Paul") Hwu
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Publication number: 20180140721Abstract: The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.Type: ApplicationFiled: November 8, 2017Publication date: May 24, 2018Applicant: Intrexon CorporationInventors: Stephen SCHAUER, Darby THOMAS, Gregory ROBINSON, Mark PYKETT, Richard THORN, Kirsten GRUIS
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Publication number: 20080064101Abstract: The invention relates to a method for lymphoid tissue-specific cell production from hematopoietic progenitor cells in unique, three-dimensional culture devices, in the presence of antigen presenting cells and lymphoreticular stromal cells, and in the absence of exogenously added growth factors. The resulting lymphoid tissue-specific cells may be isolated at any sequential stage of differentiation and further expanded. The lymphoid tissue-specific cells also may be genetically altered at any stage of the process.Type: ApplicationFiled: January 31, 2007Publication date: March 13, 2008Applicants: Cytomatrix, LLC, The General Hospital CorporationInventors: Mark Pykett, Michael Rosenzweig, David Scadden, Mark Poznansky
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Publication number: 20070148769Abstract: The invention pertains to methods and devices for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors, improved methods for the introduction of foreign genetic material into cells of hematopoietic origin, and to apparatus for performing these methods. The hematopoietic progenitor cells are cultured on a three-dimensional porous biomaterial. The three-dimensional porous biomaterial enhances hematopoietic progenitor cell survival and leads to an expansion of progenitor cell numbers and/or functionality, while maintaining progenitor cell pluripotency in the absence of exogenous growth factors. In addition, the three-dimensional porous biomaterial supports high level transduction on cells cultured upon such environment.Type: ApplicationFiled: June 26, 2006Publication date: June 28, 2007Applicant: Cytomatrix, LLCInventors: Mark Pykett, Michael Rosenzweig, Richard Kaplan
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Publication number: 20060084170Abstract: The invention pertains to methods and devices for the in vitro culture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors. The hematopoietic progenitor cells are cultured in the absence of exogenously added hematopoietic growth factors without loss in cell progenitor cell numbers and/or functionality, while maintaining progenitor cell pluripotency.Type: ApplicationFiled: May 23, 2003Publication date: April 20, 2006Inventors: Mark Pykett, Michael Rosenzweig, Todd Upton
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Publication number: 20050079609Abstract: The invention pertains to methods and devices for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors, improved methods for the introduction of foreign genetic material into cells of hematopoietic origin, and to apparatus for performing these methods. The hematopoietic progenitor cells are cultured on a three-dimensional porous biomaterial. The three-dimensional porous biomaterial enhances hematopoietic progenitor cell survival and leads to an expansion of progenitor cell numbers and/or functionality, while maintaining progenitor cell pluripotency in the absence of exogenous growth factors. In addition, the three-dimensional porous biomaterial supports high level transduction on cells cultured upon such environment.Type: ApplicationFiled: November 10, 2003Publication date: April 14, 2005Applicant: Cytomatrix, LLCInventors: Mark Pykett, Michael Rosenzweig, Richard Kaplan