Abstract: An implantable joint prosthesis simulating an elbow joint, an ankle joint, a shoulder joint or a hip joint, the implantable prosthesis having one or more integrated biasing system(s) configured to bias the prosthetic joint to one or more preferred orientations or alignments.

Abstract: A mandible support device comprising a structural member comprising a support component and an adhesive component. The support component is configured to extend from the head or face above the mandible to the region of the gonial angle, or from the gonial angle on a first side of a face to the gonial angle on a second side of a face, across the premaxilla region of the face. The adhesive component is configured such that the structural member can be temporarily attached to the skin.

Abstract: An implantable knee prosthesis comprising a femoral stem component, a tibial stem component and a hinged joint having at least one hinge pivot point and an axis of limited rotation, the implantable knee prosthesis having a prosthetic extensor system configured to simulate a level of natural movement for patients with compromised extensor systems.

Abstract: A mandible support device comprising a structural member comprising a support component and an adhesive component. The support component is configured to extend from the head or face above the mandible to the region of the gonial angle. The adhesive component is configured such that the structural member can be temporarily attached to the skin.

Abstract: A mandible support device comprising a structural member comprising a support component and an adhesive component. The support component is configured to extend from the head or face above the mandible to the region of the gonial angle, or from the gonial angle on a first side of a face to the gonial angle on a second side of a face, across the premaxilla region of the face. The adhesive component is configured such that the structural member can be temporarily attached to the skin.

Abstract: A ratcheting strut comprising: (a) a ratchet box including a through passage; (b) a first tube sized to extend at least partially through the passage, the first tube including ratchet teeth that engage corresponding ratchet teeth of the ratchet box; (c) a second tube mounted to the ratchet box in parallel with the first tube, the second tube operatively coupled to a second fixation adapter; and (d) a threaded rod operatively coupled to a nut and a first fixation adapter, the threaded rod repositionably mounted to the first tube, where the nut is operatively coupled and repositionable with respect to the first tube.

Abstract: A mandible support device comprising a structural member comprising a support component and an adhesive component. The support component is configured to extend from the head or face above the mandible to the region of the gonial angle. The adhesive component is configured such that the structural member can be temporarily attached to the skin.

Abstract: An external fixation system for reducing bone fragments, comprising: a substantially rigid frame member at least partially surrounding a fractured bone; a clamping assembly associated with the substantially rigid frame member, the clamping assembly having at least one opening for receiving a bone fixation member that is configured to penetrate the fractured bone; and a polyaxially adjustable pivot housing associated with the substantially rigid frame member, the polyaxially adjustable pivot housing being configured to cause the alignment of the bone fragments to be adjusted in response to a force exerted on the substantially rigid frame member.

Abstract: The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics.