Patents by Inventor Mark R. Claudnic
Mark R. Claudnic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10627366Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.Type: GrantFiled: January 16, 2017Date of Patent: April 21, 2020Assignee: National Technology & Engineering Solutions of Sandia, LLCInventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van De Vreugde
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Publication number: 20170122904Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.Type: ApplicationFiled: January 16, 2017Publication date: May 4, 2017Inventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van De Vreugde
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Patent number: 9579649Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.Type: GrantFiled: October 7, 2010Date of Patent: February 28, 2017Assignee: Sandia CorporationInventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van de Vreugde
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Patent number: 8940147Abstract: Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.Type: GrantFiled: April 25, 2012Date of Patent: January 27, 2015Assignee: Sandia CorporationInventors: Michael S. Bartsch, Mark R. Claudnic, Hanyoup Kim, Kamlesh D. Patel, Ronald F. Renzi, James L. Van De Vreugde
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Patent number: 8828736Abstract: We have developed an microelectroporation device that combines microarrays of oligonucleotides, microfluidic channels, and electroporation for cell transfection and high-throughput screening applications (e.g. RNA interference screens). Microarrays allow the deposition of thousands of different oligonucleotides in microscopic spots. Microfluidic channels and microwells enable efficient loading of cells into the device and prevent cross-contamination between different oligonucleotides spots. Electroporation allows optimal transfection of nucleic acids into cells (especially hard-to-transfect cells such as primary cells) by minimizing cell death while maximizing transfection efficiency. This invention has the advantage of a higher throughput and lower cost, while preventing cross-contamination compared to conventional screening technologies. Moreover, this device does not require bulky robotic liquid handling equipment and is inherently safer given that it is a closed system.Type: GrantFiled: June 30, 2011Date of Patent: September 9, 2014Assignee: Sandia CorporationInventors: Thomas D. Perroud, Ronald F. Renzi, Oscar Negrete, Mark R. Claudnic
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Patent number: 8394312Abstract: Methods for making a microfluidic device according to embodiments of the present invention include defining˜cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.Type: GrantFiled: September 20, 2011Date of Patent: March 12, 2013Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Ying-Chih Wang, Anup K. Singh, Ronald F. Renzi, Mark R. Claudnic
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Publication number: 20120085644Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.Type: ApplicationFiled: October 7, 2010Publication date: April 12, 2012Inventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van De Vreugde
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Publication number: 20120004144Abstract: We have developed an microelectroporation device that combines microarrays of oligonucleotides, microfluidic channels, and electroporation for cell transfection and high-throughput screening applications (e.g. RNA interference screens). Microarrays allow the deposition of thousands of different oligonucleotides in microscopic spots. Microfluidic channels and microwells enable efficient loading of cells into the device and prevent cross-contamination between different oligonucleotides spots. Electroporation allows optimal transfection of nucleic acids into cells (especially hard-to-transfect cells such as primary cells) by minimizing cell death while maximizing transfection efficiency. This invention has the advantage of a higher throughput and lower cost, while preventing cross-contamination compared to conventional screening technologies. Moreover, this device does not require bulky robotic liquid handling equipment and is inherently safer given that it is a closed system.Type: ApplicationFiled: June 30, 2011Publication date: January 5, 2012Inventors: Thomas D. Perroud, Ronald F. Renzi, Oscar Negrete, Mark R. Claudnic
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Patent number: 8047829Abstract: Methods for making a micofluidic device according to embodiments of the present invention include defining a cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.Type: GrantFiled: January 26, 2009Date of Patent: November 1, 2011Assignee: Sandia CorporationInventors: Gregory J. Sommer, Anson V. Hatch, Ying-Chih Wang, Anup K. Singh, Ronald F. Renzi, Mark R. Claudnic