Patents by Inventor Mark R. Claudnic

Mark R. Claudnic has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10627366
    Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: April 21, 2020
    Assignee: National Technology & Engineering Solutions of Sandia, LLC
    Inventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van De Vreugde
  • Publication number: 20170122904
    Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.
    Type: Application
    Filed: January 16, 2017
    Publication date: May 4, 2017
    Inventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van De Vreugde
  • Patent number: 9579649
    Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.
    Type: Grant
    Filed: October 7, 2010
    Date of Patent: February 28, 2017
    Assignee: Sandia Corporation
    Inventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van de Vreugde
  • Patent number: 8940147
    Abstract: Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: January 27, 2015
    Assignee: Sandia Corporation
    Inventors: Michael S. Bartsch, Mark R. Claudnic, Hanyoup Kim, Kamlesh D. Patel, Ronald F. Renzi, James L. Van De Vreugde
  • Patent number: 8828736
    Abstract: We have developed an microelectroporation device that combines microarrays of oligonucleotides, microfluidic channels, and electroporation for cell transfection and high-throughput screening applications (e.g. RNA interference screens). Microarrays allow the deposition of thousands of different oligonucleotides in microscopic spots. Microfluidic channels and microwells enable efficient loading of cells into the device and prevent cross-contamination between different oligonucleotides spots. Electroporation allows optimal transfection of nucleic acids into cells (especially hard-to-transfect cells such as primary cells) by minimizing cell death while maximizing transfection efficiency. This invention has the advantage of a higher throughput and lower cost, while preventing cross-contamination compared to conventional screening technologies. Moreover, this device does not require bulky robotic liquid handling equipment and is inherently safer given that it is a closed system.
    Type: Grant
    Filed: June 30, 2011
    Date of Patent: September 9, 2014
    Assignee: Sandia Corporation
    Inventors: Thomas D. Perroud, Ronald F. Renzi, Oscar Negrete, Mark R. Claudnic
  • Patent number: 8394312
    Abstract: Methods for making a microfluidic device according to embodiments of the present invention include defining˜cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: March 12, 2013
    Assignee: Sandia Corporation
    Inventors: Gregory J. Sommer, Anson V. Hatch, Ying-Chih Wang, Anup K. Singh, Ronald F. Renzi, Mark R. Claudnic
  • Publication number: 20120085644
    Abstract: Embodiments of fluid distribution manifolds, cartridges, and microfluidic systems are described herein. Fluid distribution manifolds may include an insert member and a manifold base and may define a substantially closed channel within the manifold when the insert member is press-fit into the base. Cartridges described herein may allow for simultaneous electrical and fluidic interconnection with an electrical multiplex board and may be held in place using magnetic attraction.
    Type: Application
    Filed: October 7, 2010
    Publication date: April 12, 2012
    Inventors: Ronald F. Renzi, Gregory J. Sommer, Anup K. Singh, Anson V. Hatch, Mark R. Claudnic, Ying-Chih Wang, James L. Van De Vreugde
  • Publication number: 20120004144
    Abstract: We have developed an microelectroporation device that combines microarrays of oligonucleotides, microfluidic channels, and electroporation for cell transfection and high-throughput screening applications (e.g. RNA interference screens). Microarrays allow the deposition of thousands of different oligonucleotides in microscopic spots. Microfluidic channels and microwells enable efficient loading of cells into the device and prevent cross-contamination between different oligonucleotides spots. Electroporation allows optimal transfection of nucleic acids into cells (especially hard-to-transfect cells such as primary cells) by minimizing cell death while maximizing transfection efficiency. This invention has the advantage of a higher throughput and lower cost, while preventing cross-contamination compared to conventional screening technologies. Moreover, this device does not require bulky robotic liquid handling equipment and is inherently safer given that it is a closed system.
    Type: Application
    Filed: June 30, 2011
    Publication date: January 5, 2012
    Inventors: Thomas D. Perroud, Ronald F. Renzi, Oscar Negrete, Mark R. Claudnic
  • Patent number: 8047829
    Abstract: Methods for making a micofluidic device according to embodiments of the present invention include defining a cavity. Polymer precursor solution is positioned in the cavity, and exposed to light to begin the polymerization process and define a microchannel. In some embodiments, after the polymerization process is partially complete, a solvent rinse is performed, or fresh polymer precursor introduced into the microchannel. This may promote removal of unpolymerized material from the microchannel and enable smaller feature sizes. The polymer precursor solution may contain an iniferter. Polymerized features therefore may be capped with the iniferter, which is photoactive. The iniferter may aid later binding of a polyacrylamide gel to the microchannel surface.
    Type: Grant
    Filed: January 26, 2009
    Date of Patent: November 1, 2011
    Assignee: Sandia Corporation
    Inventors: Gregory J. Sommer, Anson V. Hatch, Ying-Chih Wang, Anup K. Singh, Ronald F. Renzi, Mark R. Claudnic