Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Systems, devices, and methods are described for cooling extruded materials. In certain embodiments, a quench tube is provided that includes an inner wall and an outer wall having a channel therebetween for transporting cooling fluid along the quench tube. A passage within the inner surface of the inner wall receives an extruded material through a nozzle formed at an end of the quench tube that delivers the cooling fluid to the extruded material. The channel may be angled at the nozzle to deliver the cooling fluid at an angle with respect to the quench tube, and the quench tube is configured to extend at least in part within an extrusion die.

Abstract: Systems, devices, and methods for continuous extrusion of material billets are provided. A die assembly for press extrusion of a material includes a plurality of die plates forming a die body. The die body has an entrance and an exit having a diameter smaller than the entrance, with a tapered surface between the entrance and the exit. Each die plate has a center bore with a tapered interior surface, and the interior surfaces form the tapered surface that extends from the entrance to the exit. A base is coupled to the die body, and rotation of the base causes rotation of the die body. A billet pressed into the die body is heated by friction between the interior surface and an outer surface of the billet. The billet is heated to a deformable temperature and is extruded into a tube product as the billet is pressed from the entrance to the exit of the die body.

Abstract: Systems, devices, and methods are described for cooling extruded materials. In certain embodiments, a quench tube is provided that includes an inner wall and an outer wall having a channel therebetween for transporting cooling fluid along the quench tube. A passage within the inner surface of the inner wall receives an extruded material through a nozzle formed at an end of the quench tube that delivers the cooling fluid to the extruded material. The channel may be angled at the nozzle to deliver the cooling fluid at an angle with respect to the quench tube, and the quench tube is configured to extend at least in part within an extrusion die.