Patents by Inventor MARK R FREWIN

MARK R FREWIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody variants
    Patent number: 8440190
    Abstract: This invention relates to an antibody which is modified version of a therapeutic antibody with affinity for a cell-surface antigen, the antibody having reduced affinity for the antigen compared with the therapeutic antibody as a result of a modification or modifications to the antibody molecule, wherein the antibody is capable of inducing immunological tolerance to the therapeutic antibody. The invention further relates to a method of inducing immunological tolerance to a therapeutic antibody, comprising administering to a patient an antibody which is a modified version of the therapeutic antibody and which has reduced affinity for the antigen as compared with the therapeutic antibody.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: May 14, 2013
    Assignee: Isis Innovation Limited
    Inventors: Herman Waldmann, Lisa K Gilliland, Masahide Tone, Mark R Frewin, Louise Walsh
  • ANTIBODY VARIANTS
    Publication number: 20020048578
    Abstract: This invention relates to an antibody which is a modified version of a therapeutic antibody with affinity for a cell-surface antigen, said antibody having reduced affinity for the antigen compared with the therapeutic antibody as a result of a modification or modifications to the antibody molecule, wherein the antibody is capable of inducing immunological tolerance to the therapeutic antibody. The invention further relates to a method of inducing immunological tolerance to a therapeutic antibody comprising administering to a patient an antibody which is a modified version of the therapeutic antibody and which has reduced affinity for the antigen as compared with the therapeutic antibody.
    Type: Application
    Filed: August 19, 1998
    Publication date: April 25, 2002
    Inventors: HERMAN WALDMANN, LISA K GILLILAND, MASAHIDE TONE, MARK R FREWIN, LOUISE WALSH