Patents by Inventor Mark R. Frey

Mark R. Frey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating diseases mediated by ERBB4-positive pro-inflammatory macrophages
    Patent number: 11524055
    Abstract: Provided herein are methods and compositions for treating disease-states associated with presence of increased number of ErbB4+ pro-inflammatory macrophages in a subject in need thereof. The methods include providing an activator of ErbB4 and administering a therapeutically effective amount of the activator to the subject. The compositions include an activator of ErbB4. In one embodiment, the activation of ErbB4 is Neuregulin-4.
    Type: Grant
    Filed: May 26, 2020
    Date of Patent: December 13, 2022
    Assignee: Children's Hospital Los Angeles
    Inventors: Mark R. Frey, Michael Schumacher
  • METHODS FOR TREATING DISEASES MEDIATED BY ERBB4-POSITIVE PRO-INFLAMMATORY MACROPHAGES
    Publication number: 20200353043
    Abstract: Provided herein are methods and compositions for treating disease-states associated with presence of increased number of ErbB4+ pro-inflammatory macrophages in a subject in need thereof. The methods include providing an activator of ErbB4 and administering a therapeutically effective amount of the activator to the subject. The compositions include an activator of ErbB4. In one embodiment, the activation of ErbB4 is Neuregulin-4.
    Type: Application
    Filed: May 26, 2020
    Publication date: November 12, 2020
    Applicant: Children's Hospital Los Angeles
    Inventors: Mark R. Frey, Michael Schumacher
  • ERBB4 activator screening assay
    Patent number: 10716830
    Abstract: The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and necrotizing enterocolitis in a subject in need thereof by administering an effective amount of a composition comprising an activator of ErbB4.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: July 21, 2020
    Assignee: Children's Hospital Los Angeles
    Inventor: Mark R. Frey
  • Methods for treating diseases mediated by ErbB4-positive pro-inflammatory macrophages
    Patent number: 10702586
    Abstract: Provided herein are methods and compositions for treating disease-states associated with presence of increased number of ErbB4+ pro-inflammatory macrophages in a subject in need thereof. The methods include providing an activator of ErbB4 and administering a therapeutically effective amount of the activator to the subject. The compositions include an activator of ErbB4. In one embodiment, the activation of ErbB4 is Neuregulin-4.
    Type: Grant
    Filed: September 27, 2016
    Date of Patent: July 7, 2020
    Assignee: Children's Hospital Los Angeles
    Inventors: Mark R. Frey, Michael Schumacher
  • USE OF NEUREGULIN-4 FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE AND NECROTIZING ENTEROCOLITIS
    Publication number: 20180318391
    Abstract: The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and necrotizing enterocolitis in a subject in need thereof by administering an effective amount of a composition comprising an activator of ErbB4.
    Type: Application
    Filed: May 18, 2018
    Publication date: November 8, 2018
    Applicant: Children's Hospital Los Angeles
    Inventor: Mark R. Frey
  • METHODS FOR TREATING DISEASES MEDIATED BY ERBB4-POSITIVE PRO-INFLAMMATORY MACROPHAGES
    Publication number: 20180271944
    Abstract: Provided herein are methods and compositions for treating disease-states associated with presence of increased number of ErbB4+ pro-inflammatory macrophages in a subject in need thereof. The methods include providing an activator of ErbB4 and administering a therapeutically effective amount of the activator to the subject. The compositions include an activator of ErbB4. In one embodiment, the activation of ErbB4 is Neuregulin-4.
    Type: Application
    Filed: September 27, 2016
    Publication date: September 27, 2018
    Applicant: Children's Hospital Los Angeles
    Inventors: Mark R. Frey, Michael Schumacher
  • USE OF NEUREGULIN-4 FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE AND NECROTIZING ENTEROCOLITIS
    Publication number: 20160317619
    Abstract: The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and necrotizing enterocolitis in a subject in need thereof by administering an effective amount of a composition comprising an activator of ErbB4.
    Type: Application
    Filed: April 26, 2016
    Publication date: November 3, 2016
    Applicant: Children's Hospital Los Angeles
    Inventor: Mark R. Frey
  • Use of neuregulin-4 for treatment of inflammatory bowel disease and necrotizing enterocolitis
    Patent number: 9352023
    Abstract: The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and necrotizing enterocolitis in a subject in need thereof by administering an effective amount of a composition comprising an activator of ErbB4.
    Type: Grant
    Filed: August 15, 2012
    Date of Patent: May 31, 2016
    Assignee: Children's Hospital Los Angeles
    Inventor: Mark R. Frey
  • USE OF NEUREGULIN-4 FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE AND NECROTIZING ENTEROCOLITIS
    Publication number: 20140178404
    Abstract: The invention provides methods, pharmaceutical compositions and kits for treating, inhibiting and/or reducing the severity of inflammatory bowel disease and necrotizing enterocolitis in a subject in need thereof by administering an effective amount of a composition comprising an activator of ErbB4.
    Type: Application
    Filed: August 15, 2012
    Publication date: June 26, 2014
    Applicant: CHILDREN'S HOSPITAL LOS ANGELES
    Inventor: Mark R. Frey