Patents by Inventor Mark R. Hagadone

Mark R. Hagadone has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of carboxylic acid glucuronides
    Patent number: 5633357
    Abstract: A method of producing a carboxylic acid glucuronide by reacting a carboxylic acid precursor with a blocked sugar epoxide precursor is disclosed. Also disclosed are: deuterated 11-nor-.DELTA..sup.8 - or .DELTA..sup.9 -THC carboxylic acid glucuronide having a deuterated hydrocarbon chain; 5'-deuterated 11-nor-.DELTA..sup.8 - or .DELTA..sup.9 -THC-carboxylic acid or 5'-deuterated .DELTA..sup.8 - or .DELTA..sup.9 -THC glucuronide. The compositions are useful as GC-MS standards; in methods for preparing antibodies reactive with a THC glucuronide; and, in GC-MS diagnostic methods for THC metabolites.
    Type: Grant
    Filed: March 4, 1994
    Date of Patent: May 27, 1997
    Assignee: Synthetic Technology Corporation
    Inventors: Marcus A. Tius, Mark R. Hagadone
  • Synthesis of 11-nor-.DELTA.-9-tetrahydrocannabinol-9-carboxylic acid glucuronide
    Patent number: 5292899
    Abstract: A method of producing a deuterated or undeuterated 11-nor-.DELTA..sup.8 -tetrahydrocannabinol (THC) glucuronide or deuterated or undeuterated 11-nor-.DELTA..sup.9 -THC glucuronide by reacting a blocked THC carboxylic acid precursor with a blocked sugar epoxide precursor is disclosed. Also disclosed are: deuterated 11-nor-.DELTA..sup.8 - or .DELTA..sup.9 -THC carboxylic acid glucuronide having a deuterated hydrocarbon chain; 5'-deuterated 11-nor-.DELTA..sup.8 - or .DELTA..sup.9 -THC-carboxylic acid or 5'-deuterated .DELTA..sup.8 - or .DELTA..sup.9 -THC glucuronide. The compositions are useful as GC-MS standards; in methods for preparing antibodies reactive with a THC glucuronide; and, in GC-MS diagnostic methods for THC metabolites.
    Type: Grant
    Filed: November 27, 1991
    Date of Patent: March 8, 1994
    Assignee: Synthetic Technology Corporation
    Inventors: Marcus A. Tius, Mark R. Hagadone