Patents by Inventor Mark R. Herman
Mark R. Herman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20120082729Abstract: The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.Type: ApplicationFiled: December 8, 2011Publication date: April 5, 2012Applicant: VALEANT INTERNATIONAL (BARBADOS) SRLInventors: Naima MEZAACHE, Steven E. Frisbee, Patrick B. Woodall, Mark R. Herman
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Patent number: 7815937Abstract: The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.Type: GrantFiled: June 21, 2002Date of Patent: October 19, 2010Assignee: Biovail Laboratories International SRLInventors: Naima Mezaache, Steven E. Frisbee, Patrick B. Woodall, Mark R. Herman, Djelila Mezaache
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Publication number: 20100178353Abstract: The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.Type: ApplicationFiled: March 24, 2010Publication date: July 15, 2010Applicant: BIOVAIL LABORATORIES INTERNATIONAL S.R.L.Inventors: Naima MEZAACHE, Steven E. Frisbee, Patrick B. Woodall, Mark R. Herman
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Publication number: 20030124184Abstract: The invention provides a composition useful for making oral dosage forms capable of dissolving in the mouth in less than 40 seconds without the need for a conventional super disintegrant and having a friability of less than 1%; wherein the composition includes liquiflash particles and an excipient mass. A preferred excipient mass according to the invention contains a directly compressible inorganic salt; a cellulose derivative or a combination of a directly compressible inorganic salt and a cellulose derivative. Preferably, the liquiflash particles and the excipient mass are combined in proportions such that the active ingredient remains substantially within the microspheres when the composition is compressed to obtain a dosage form having a hardness of 20 to 50 N. The compositions of the invention allow for the fabrication of oral dosages having improved hardness and friability.Type: ApplicationFiled: June 21, 2002Publication date: July 3, 2003Applicant: BiovailInventors: Naima Mezaache, Steven E. Frisbee, Patrick B. Woodall, Mark R. Herman
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Patent number: 6117452Abstract: The thermoforming of compositions containing active agents is carried out by processing compositions containing certain fatty esters in combination.Type: GrantFiled: August 12, 1998Date of Patent: September 12, 2000Assignee: Fuisz Technologies Ltd.Inventors: Nils Ahlgren, Joseph Cascone, Joan Fitzpatrick, Steven E. Frisbee, John Getz, Mark R. Herman, Bernard M. Kiernan, Barbara Montwill, Ed O'Donnell, Desiree Pereira, Pradeepkumar P. Sanghvi
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Patent number: 6083430Abstract: The present invention is a process and apparatus for making a dosage unit by direct tableting of shearlite particles. The present invention also includes the dosage unit itself. Shearlite particles, which are prepared by subjecting a feedstock material to liquiflash processing, can be directly fed from a shearlite device to a tableting apparatus without the necessity of any intermediate steps or additional ingredients to facilitate flowability or tablet formation.Type: GrantFiled: April 29, 1996Date of Patent: July 4, 2000Assignee: Fuisz Technologies Ltd.Inventors: Richard C. Fuisz, Garry L. Myers, Robert K. Yang, Mark R. Herman, Whitney S. Cavanagh, John R. Sisak, Andrea S. Brothers
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Patent number: 5965164Abstract: A recipient-dosage delivery system including shearlite particles of a bio-affecting agent for delivery to a recipient. The particles are provided in a metered dose and are packaged in a bi-functional vessel. The particles are produced under liquiflash conditions and exhibit sufficient flowability so as to allow administration of the metered dose to the recipient under the force of gravity.Type: GrantFiled: April 29, 1996Date of Patent: October 12, 1999Assignee: Fuisz Technologies Ltd.Inventors: Richard C. Fuisz, Robert K. Yang, Whitney S. Cavanagh, Garry L. Myers, Mark R. Herman
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Patent number: 5849223Abstract: The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded internal flow. Shear force is imparted to the liquiform feedstock in an amount sufficient to separate tiny masses of feedstock. The tiny masses solidify as discretized particles. The present invention also includes unique products resulting from the process, e.g., a monodispersed microsphere product and coated particles prepared therefrom.Type: GrantFiled: May 26, 1995Date of Patent: December 15, 1998Assignee: Fuisz Technologies Ltd.Inventors: Garry L. Myers, Robert K. Yang, Mark R. Herman
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Patent number: 5683720Abstract: The present invention is a method of making discrete particles by subjecting an organic feedstock to liquiflash conditions whereby the feedstock is transformed instantaneously from solid to liquiform to solid. Liquiform is a transient condition wherein the feedstock has substantially unimpeded internal flow. Shear force is imparted to the liquiform feedstock in an amount sufficient to separate tiny masses of feedstock. The tiny masses solidify as discretized particles. The present invention also includes unique products resulting from the process, e.g., a monodispersed microsphere product and coated particles prepared therefrom.Type: GrantFiled: October 28, 1994Date of Patent: November 4, 1997Assignee: Fuisz Technologies Ltd.Inventors: Garry L. Myers, Robert K. Yang, Mark R. Herman