Patents by Inventor Mark R. Kelley, III

Mark R. Kelley, III has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF APE/REF-1 REDOX SPECIFIC INHIBITORS FOR TREATING METASTATIC PROSTATE CANCER
    Publication number: 20190365689
    Abstract: Methods of using redox APE1/Ref-1 inhibitors to treat prostate cancer, and particularly, metastatic prostate cancer, are disclosed. Particularly, small molecule inhibitors of APE1/Ref-1 redox activity have been found to decrease cell proliferation and induce cell cycle arrest in metastatic prostate cancer cell lines. Further, these APE1/Ref-1 redox inhibitors can be used to reduce expression of survivin, which has been shown to be overexpressed in primary and metastatic tumors.
    Type: Application
    Filed: January 25, 2018
    Publication date: December 5, 2019
    Inventors: Mark R. Kelley, III, Travis Jerde, Melissa L. Fishel