Patents by Inventor Mark R. Kelley

Mark R. Kelley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for the use of apurinic/apyrimidinic endonucleases
    Patent number: 6190661
    Abstract: Disclosed are methods and compositions for identifying, monitoring and treating premalignant and malignant conditions in a human subject. The present invention further discloses methods and compositions for determining cells undergoing apoptosis, and for increasing the efficacy of a cancer therapy. The methods involve the use of apurinic/apyrimidinic endonuclease (APE), independently, as a marker for (pre)malignant conditions and for apoptosis. Also described are polyclonal antibody preparations for use in methods for detecting APE and methods for modulating expression susceptibility of cells to apoptosis.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: February 20, 2001
    Assignee: Advanced Research & Technology Institute
    Inventors: Mark R. Kelley, John Duquid, John Eble
  • Methods and compositions for the use of apurinic/apyrimidinic endonucleases
    Patent number: 5919643
    Abstract: Disclosed are methods and compositions for identifying, monitoring and treating premalignant and malignant conditions in a human subject. The present invention further discloses methods and compositions for determining cells undergoing apoptosis, and for increasing the efficacy of a cancer therapy. The methods involve the use of apurinic/apyrimidinic endonuclease (APE), independently, as a marker for (pre)malignant conditions and for apoptosis. Also described are polyclonal antibody preparations for use in methods for detecting APE and methods for modulating expression susceptibility of cells to apoptosis.
    Type: Grant
    Filed: June 11, 1997
    Date of Patent: July 6, 1999
    Assignee: Advanced Research & Technology Institute
    Inventors: Mark R. Kelley, John Duguid, John Eble
  • Plug for pier hole
    Patent number: 4911586
    Abstract: An inflatable, stretchable plug for obstructing a hole drilled in the ground for a foundation pier comprises a sturdy elastic envelope having an air valve mounted in the wall thereof for connection with outside supply of pressurized air and a handle bonded to upper portion of the envelope for easy removal of the plug from the hole before concrete mixture is poured in to produce the pier.
    Type: Grant
    Filed: January 18, 1989
    Date of Patent: March 27, 1990
    Assignee: Mark R. Kelley
    Inventors: Mark R. Kelley, Ronald P. Mackwood, John M. Broderick