Patents by Inventor Mark R. Philips

Mark R. Philips has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170291958
    Abstract: Described herein is a method of modulating sumoylation of a Ras protein by small ubiquitin-like modifier (SUMO) proteins. Provided herein is a method for regulating the activity of a Ras protein. Also provided is a treatment of proliferative diseases, such as cancer, by introducing specific mutations to a mutant Ras protein that is associated with the proliferative disease. Described herein is a modified Ras protein. Described herein are recombinant vectors, cells comprising the vectors expressing the modified Ras proteins. Provided herein is an antibody that specifically binds to a sumoylated Ras protein. Described herein is a method for identifying an agent that interferes with the sumoylation of a Ras protein. Also described herein are therapeutic and prophylactic compositions. Also provided herein is a method of using a modified Ras protein to replace an endogenous mutant Ras protein that is associated with a proliferative disease.
    Type: Application
    Filed: April 11, 2017
    Publication date: October 12, 2017
    Inventors: Wei Dai, Mark R. Philips, Byeong Hyeok Choi
  • Patent number: 8945851
    Abstract: The present invention relates to a kit for detection of association of a peripheral cellular membrane binding protein with cellular membranes in living cells and methods thereof. The kit includes a first nucleic acid construct comprising a first nucleic acid molecule encoding a first fusion protein comprising a peripheral cellular membrane binding protein or membrane binding domain thereof operatively coupled to DNA binding and transactivation domains of a naturally occurring or chimeric transcription factor and a first promoter operatively associated with the first nucleic acid molecule. A second nucleic acid construct comprises a second nucleic acid molecule encoding a reporter protein and a second promoter responsive to the DNA binding and transactivation domains of the first fusion protein. The second promoter is operatively associated with the second nucleic acid molecule. Activation of the second promoter results in expression of the reporter protein. Also disclosed is a transgenic non-human animal.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: February 3, 2015
    Assignee: New York University
    Inventors: Mark R. Philips, Nicole Fehrenbacher, Joseph Wynne
  • Publication number: 20120066782
    Abstract: The present invention relates to a kit for detection of association of a peripheral cellular membrane binding protein with cellular membranes in living cells and methods thereof. The kit includes a first nucleic acid construct comprising a first nucleic acid molecule encoding a first fusion protein comprising a peripheral cellular membrane binding protein or membrane binding domain thereof operatively coupled to DNA binding and transactivation domains of a naturally occurring or chimeric transcription factor and a first promoter operatively associated with the first nucleic acid molecule. A second nucleic acid construct comprises a second nucleic acid molecule encoding a reporter protein and a second promoter responsive to the DNA binding and transactivation domains of the first fusion protein. The second promoter is operatively associated with the second nucleic acid molecule. Activation of the second promoter results in expression of the reporter protein. Also disclosed is a transgenic non-human animal.
    Type: Application
    Filed: August 31, 2011
    Publication date: March 15, 2012
    Applicant: NEW YORK UNIVERSITY
    Inventors: Mark R. PHILIPS, Nicole FEHRENBACHER, Joseph WYNNE
  • Patent number: 7767417
    Abstract: The present invention relates to a method of identifying compounds as candidate drugs for treatment of cancer by providing a cell expressing a GTPase protein that is regulated by a prenyl-electrostatic switch, contacting the cell with compounds to be evaluated, and selecting compounds able to regulate charge at the prenyl-electrostatic switch in the GTPase protein as candidate drugs for treatment of cancer. Also disclosed are methods of treating cancer in a patient. An isolated antibody which binds to a phosphorylated prenyl-electrostatic switch on a K-Ras4B protein is also disclosed, as is a kit for detecting phosphorylation of a prenyl-electrostatic switch in a K-Ras4B protein which includes a labeled antibody and a device to detect the label. Also disclosed is a method of detecting phosphorylation of a prenyl-electrostatic switch on a K-Ras4B protein in a biological sample.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: August 3, 2010
    Assignee: New York University
    Inventors: Mark R. Philips, Trever G. Bivona
  • Patent number: 6432403
    Abstract: An antibody specific for the mammalian protein prenylcysteine carboxyl methyltransferase.
    Type: Grant
    Filed: November 8, 2000
    Date of Patent: August 13, 2002
    Assignee: New York University
    Inventor: Mark R. Philips
  • Patent number: 6232108
    Abstract: A mammalian protein, prenylcysteine carboxyl methyltransferase, involved in further post-translational modification of prenylated proteins, is cloned, characterized, and expressed in non-native cells. Such membrane preparations can be used to screen for inhibitors of prenylcysteine carboxyl methyltransferase activity.
    Type: Grant
    Filed: October 22, 1999
    Date of Patent: May 15, 2001
    Assignee: New York University
    Inventor: Mark R. Philips
  • Patent number: 6184016
    Abstract: A mammalian protein, prenylcysteine carboxyl methyltransferase, involved in further post-translational modification of prenylated proteins, is cloned, characterized, and expressed in non-native cells. Such membrane preparations can be used to screen for inhibitors of prenylcysteine carboxyl methyltransferase activity.
    Type: Grant
    Filed: June 11, 1998
    Date of Patent: February 6, 2001
    Assignee: New York University
    Inventor: Mark R. Philips