Patents by Inventor Mark R. Pope
Mark R. Pope has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220276256Abstract: The disclosure provides kits and methods for detecting a substance that interferes with detection of an analyte in a sample and for expanding the dynamic range and reducing the hook effect of an immunoassay. The kits and methods employ two conjugates with two different detectable labels, at least one of which is a chemiluminescent compound of Formula (I).Type: ApplicationFiled: August 6, 2020Publication date: September 1, 2022Inventors: Mark R. Pope, Stefan J. Hershberger, Qiaoqiao Ruan, Kerry M. Swift, Sergey Y. Tetin, Patrick Macdonald, Richard A. Haack
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Patent number: 11022598Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.Type: GrantFiled: October 3, 2017Date of Patent: June 1, 2021Assignee: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew S. Schapals, Anthony S. Muerhoff, M. Felicia Bogdan, Thomas Leary, Shelley R. Holets-McCormack, Sophie Laurenson, Andrew T. Fischer, Richard Haack, Stefan Hershberger, Dustin House, Lei Qiao, M. Shawn Murphy, Mark R. Pope, Edna M. Prieto-Ballengee, QiaoQiao Ruan, Pathik Soni, Sergey Tetin, Lyle Yarnell
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Publication number: 20200256843Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.Type: ApplicationFiled: May 1, 2020Publication date: August 13, 2020Applicant: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew S. Schapals, Anthony S. Muerhoff, M. Felicia Bogdan, Thomas Leary, Shelley R. Holets-McCormack, Sophie Laurenson, Andrew T. Fischer, Richard Haack, Stefan Hershberger, Dustin House, Lei Qiao, M. Shawn Murphy, Mark R. Pope, Edna M. Prieto-Ballengee, QiaoQiao Ruan, Pathik Soni, Sergey Tetin, Lyle Yarnell
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Publication number: 20200209250Abstract: The disclosure provides methods of analyzing an analyte of interest in a biological sample using fluorescent agents and macroconjugates which comprise a core containing a cross-linked polymer or protein, tags, specific binding members or fragments thereof, and optionally carrier proteins. Also provided are methods of analyzing two or more analytes of interest in a biological sample in a single assay using microparticles and detection conjugates comprising different fluorophore labels, acquiring transmitted light and fluorescent images of the microparticles, and using a customized image analysis process to analyze the acquired images.Type: ApplicationFiled: December 27, 2019Publication date: July 2, 2020Inventors: Qiaoqiao Ruan, Patrick J. Macdonald, Kerry M. Swift, Sergey Y. Tetin, Brenda Calfin, Zhen Lin, Richard Haack, Mark R. Pope, John Prostko, Xiaoxing Qiu, Felicia Bogdan
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Publication number: 20180188230Abstract: Methods, devices, and systems for analyte analysis using a nanopore are disclosed. The methods, devices, and systems utilize a first and a second binding member that each specifically bind to an analyte in a biological sample. The method further includes detecting and/or counting a cleavable tag attached to the second binding member and correlating the presence and/or the number of tags to presence and/or concentration of the analyte. Certain aspects of the methods do not involve a tag, rather the second binding member may be directly detected/quantitated. The detecting and/or counting may be performed by translocating the tag/second binding member through a nanopore. Devices and systems that are programmed to carry out the disclosed methods are also provided.Type: ApplicationFiled: October 3, 2017Publication date: July 5, 2018Applicant: ABBOTT LABORATORIESInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew S. Schapals, Anthony S. Muerhoff, Felicia Bogdan, Thomas Leary, Shelley R. Holets-McCormack, Sophie Laurenson, Andrew T. Fischer, Richard Haack, Stefan Hershberger, Dustin House, Lei Qiao, M. Shawn Murphy, Mark R. Pope, Edna M. Prieto-Ballengee, QiaoQiao Ruan, Pathik Soni, Sergey Tetin, Lyle Yarnell
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Publication number: 20180095067Abstract: Integrated microfluidic and analyte detection devices are disclosed, along with methods of detecting target analytes. Digital microfluidic and analyte detection devices include a first substrate and a second substrate aligned generally parallel to each other to define a gap therebetween, the first substrate including a plurality of electrodes to generate electrical actuation forces on a liquid droplet disposed in the gap; at least one reagent disposed on at least one of the first substrate or the second substrate and configured to be carried by the liquid droplet; and an analyte detection device in fluid communication with the gap, wherein the plurality of electrodes are configured to move the liquid droplet towards the analyte detection device.Type: ApplicationFiled: October 3, 2017Publication date: April 5, 2018Applicant: Abbott LaboratoriesInventors: Jeffrey B. Huff, Mark A. Hayden, Peter J. Karabatsos, Andrew S. Schapals, Anthony S. Muerhoff, Felicia Bogdan, Thomas Leary, Shelley R. Holets-McCormack, Sophie Laurenson, Andrew T. Fischer, Richard Haack, Stefan Hershberger, Dustin House, Lei QIAO, M. Shawn Murphy, Mark R. Pope, Edna M. Prieto-Ballengee, QiaoQiao Ruan, Pathik Soni, Sergey Tetin, Lyle Yarnell, John M. Robinson
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Patent number: 6786874Abstract: The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.Type: GrantFiled: September 13, 2002Date of Patent: September 7, 2004Assignee: Abbott LaboratoriesInventors: John P. Grace, Neil W. Loomis, Thomas G. Schapira, Sie Ting Wong, Kristin M. Noonan, Michael G. Lowery, Pete M. Bojan, Daniel P. Schmidt, Tung-Ming Huang, Robert G. Hiltibran, Mark R. Pope, John J. Kotlarik, Brian Joseph Tarkowski, David Dean Cunningham
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Patent number: 6679841Abstract: An article capable of both collecting interstitial fluid and detecting an analyte in that fluid and a method for use of that article. Preferably, the article is also capable of measuring the amount of analyte in the interstitial fluid. The article can be used in conjunction with a meter that contains an appropriate detection element for determining the amount of analyte in the interstitial fluid.Type: GrantFiled: June 15, 2001Date of Patent: January 20, 2004Assignee: Abbott LaboratoriesInventors: Peter M. Bojan, Timothy P. Henning, Neil W. Loomis, Mark R. Pope, Jonathan A. Eppstein
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Publication number: 20030114774Abstract: The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.Type: ApplicationFiled: September 13, 2002Publication date: June 19, 2003Inventors: John P. Grace, Neil W. Loomis, Thomas G. Schapira, Sie Ting Wong, Kristin M. Noonan, Michael G. Lowery, Pete M. Bojan, Daniel P. Schmidt, Tung-Ming Huang, Robert G. Hiltibran, Jon G. Hiltibran, Mark R. Pope, John J. Kotlarik, Brian Joseph Tarkowski, David Dean Cunningham
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Patent number: 6569157Abstract: The invention involves a method for focusing light comprising the steps of: projecting at least one pulse of light onto the surface of the skin of a patient; collecting at least a portion of the light that is reflected from the skin of the patient; projecting the collected, reflected light onto a detector; and adjusting the projection of the pulsed light onto the surface of the skin of the patient in such a manner that the signal projected onto the detector is optimized. When the light pulse is properly focused, e.g., when it is characterized by the best focus, it can be used to provide energy to form an opening in the skin of the patient. When more than one pulse of light is required to form an opening in the skin of the patient, aligning the light prior to each pulse will improve the efficiency of formation of the opening.Type: GrantFiled: May 18, 1998Date of Patent: May 27, 2003Assignee: Abbott LaboratoriesInventors: Eric B. Shain, Mark R. Pope, Joseph L. Pezzaniti
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Patent number: 6468229Abstract: The present invention involves apparatus and methods for use in collecting bodily fluids, such as interstitial fluids, from the epidermal layer of an animal. A preferred apparatus includes a pressure head and, optionally, a holder therefor for supplying a positive pressure to the head. The methods include the application of a positive pressure to the area surrounding an epidermal site from which stratum corneum has been breached, such as by laser ablation, to cause bodily fluids, such as interstitial fluids, to exude from the site and collecting the fluids exuding therefrom.Type: GrantFiled: January 26, 2001Date of Patent: October 22, 2002Assignee: Abbott LaboratoriesInventors: John P. Grace, Neil W. Loomis, Thomas G. Schapira, Sie Ting Wong, Kristin M. Noonan, Michael G. Lowery, Pete M. Bojan, Daniel P. Schmidt, Tung-Ming Huang, Robert G. Hiltibran, Mark R. Pope, John J. Kotlarik, Brian Joseph Tarkowski, David Dean Cunningham
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Publication number: 20020099308Abstract: An article capable of both collecting interstitial fluid and detecting an analyte in that fluid and a method for use of that article. Preferably, the article is also capable of measuring the amount of analyte in the interstitial fluid. The article can be used in conjunction with a meter that contains an appropriate detection element for determining the amount of analyte in the interstitial fluid.Type: ApplicationFiled: June 15, 2001Publication date: July 25, 2002Inventors: Peter M. Bojan, Timothy P. Henning, Neil W. Loomis, Mark R. Pope, Jonathan A. Eppstein
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Patent number: 6312888Abstract: An article and a method for monitoring the concentration of an analyte, e. g., glucose, in blood. In one aspect, the invention involves an article comprising a multiple-layer element. In one embodiment, the article comprises: a multiple-layer element comprising: (a) a base layer (b) a cover layer, the cover layer having a first opening for venting the multiple-layer element and a second opening for receiving a biological sample; and (c) a core layer having a first major surface and a second major surface, the core layer disposed between the base layer and the cover layer, the core layer comprising a sample introduction chamber and a optical reading chamber, the first major surface of the core layer in face-to-face contact with the base layer, the second major surface of the core layer in face-to-face contact with the cover layer.Type: GrantFiled: October 16, 2000Date of Patent: November 6, 2001Assignee: Abbott LaboratoriesInventors: Sie Ting Wong, Robert G. Hiltibran, Tung-Ming Huang, Brenda B. Calfin, Mark R. Pope, Thomas G. Schapira, Eric B. Shain, Douglas F. Young
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Patent number: 6245060Abstract: A method for increasing the permeability of the stratum corneum by means of a source of light, preferably a laser, more preferably a pulsed laser. By increasing the permeability of the stratum corneum, access to the interstitial fluid is achieved, thereby enabling measurement of analytes in the interstitial fluid. In one aspect, the method comprises the steps of: (a) providing a source of light having a wavelength of from about 930 nm to about 1040 nm; and (b) exposing a region of the stratum corneum of the patient to said source of light for a period of time sufficient to form an opening in the stratum corneum.Type: GrantFiled: December 27, 1999Date of Patent: June 12, 2001Assignee: Abbott LaboratoriesInventors: Neil W. Loomis, Peter M. Bojan, Timothy P. Henning, Mark R. Pope, Andrew J. Muetterties
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Patent number: 6027496Abstract: A method for increasing the permeability of the stratum corneum by means of a source of light, preferably a laser, more preferably a pulsed laser. By increasing the permeability of the stratum corneum, access to the interstitial fluid is achieved, thereby enabling measurement of analytes in the interstitial fluid. In one aspect, the method comprises the steps of:(a) providing a source of light having a wavelength of from about 930 nm to about 1040 nm; and(b) exposing a region of the stratum corneum of the patient to said source of light for a period of time sufficient to form an opening in the stratum corneum.Type: GrantFiled: March 25, 1997Date of Patent: February 22, 2000Assignee: Abbott LaboratoriesInventors: Neil W. Loomis, Peter M. Bojan, Timothy P. Henning, Mark R. Pope, Andrew J. Muetterties
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Patent number: 5681754Abstract: A method for increasing the binding activity of specific binding members bound to a solid phase material, e.g., a particle, that has been sterically stabilized. This increase in binding activity is brought about by degrading a steric stabilizer on the surface of the solid phase material. The method involves both immobilizing a specific binding member on the surface of a solid phase material and degrading a steric stabilizer on the surface of that solid phase material. In the preferred embodiment, the method involves the immobilization of a specific binding member on the surface of the sterically stabilized solid phase material, with subsequent degradation of the steric stabilizer.Type: GrantFiled: June 7, 1996Date of Patent: October 28, 1997Assignee: Abbott LaboratoriesInventors: Mark R. Pope, Peter J. Tarcha, David R. Mees, Mary K. Joseph, Terry A. Pry, C. Brent Putman, Daniel D. Subotich
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Patent number: 5399501Abstract: A specific binding member such as an antigen or antibody is immobilized by covalent attachment to a solid phase such as a latex microparticle. The solid phase is reacted with a heterobifunctional or homobifunctional coupling agent to form a complex that is then reacted with a dithiol compound to form a thiolated solid phase. A specific binding member is reacted with the coupling agent to form a complex which is then reacted with the thiolated solid phase to link the specific binding member to the solid phase through thioethers. Alternatively, the dithiol compound may be reacted with the specific binding member/coupling agent complex to form a thiolated complex that is reacted with the solid phase/coupling agent complex. The coupling agent may contain a spacer. In another embodiment, the solid phase is reacted with a disulfide compound to form a complex and the complex is reacted with a reductant to form a thiolated solid phase which is reacted with a specific binding member/coupling agent complex.Type: GrantFiled: March 16, 1992Date of Patent: March 21, 1995Assignee: Abbott LaboratoriesInventors: Mark R. Pope, Kevin M. Knigge
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Patent number: 5272260Abstract: Novel pyrene-trisulfonate derivatives and the use thereof in a method for the determination of glycohydrolytic enzyme activity are provided. The method comprises the steps of (a) forming a test solution comprising a test sample containing the glycohydrolytic enzyme and a pyrene-trisulfonate derivative of the present invention, wherein the derivative is hydrolyzed by the glycohydrolytic enzyme to result in the formation of free 8-hydroxy-1,3,6-pyrene trisulfonate as a function of, and which can be correlated to, the amount of the glycohydrolytic enzyme present in the test sample, and (b) measuring and correlating either the intensity of fluorescence, or the optical density, of the test solution to the presence or amount of the glycohydrolytic enzyme in the test sample. A preferred pyrene-trisulfonate derivative is pyrene-1,3,6-trisulfonic acid) 8-.beta. -D-glucuronide for the determination of .beta.-D-glucuronidase for the diagnosis of periodontal disease.Type: GrantFiled: January 29, 1992Date of Patent: December 21, 1993Assignee: Abbott LaboratoriesInventors: Mark R. Pope, Christopher Bieniarz
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Patent number: 5136027Abstract: A high concentration of renaturing surfactants is added to protein systems in the presence of alkyl sulfate detergents to displace the detergent with respect to the interaction with the protein, thereby renaturing the protein and restoring its reactivity. The presence of higher quantities of detergent in the system results in smaller protein aggregates, and thus a higher reactivity and specificity as measured for the system in its entirety.Type: GrantFiled: May 2, 1989Date of Patent: August 4, 1992Assignee: Abbott LaboratoriesInventor: Mark R. Pope