Abstract: Provided herein are compositions and methods related to purification of recombinant adeno-associated virus (rAAV) particles.

Abstract: Provided herein are compositions and methods related to purification of recombinant adeno-associated virus (rAAV) particles.

Abstract: A computer system comprising a plurality of computing entities includes automatic power management logic that automatically transitions the system to a state in which less power is consumed when appropriate. The determination as to when this transition should occur is based on determining when demand for the processing abilities of the system are reduced. Once the decision has been made to transition to a reduced power state, the system's power management logic makes this transition in such a way to preferably minimize or at least reduce the performance impact on the system. Also, rather than altering the power state of one of the computing entities in the system, the entity can be deployed as part of another computing system.

Abstract: Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1×1012–1×1013 vector genomes/ml.

Abstract: Vectors that encode Adeno-Associated Virus (AAV) Rep and Cap proteins of different serotypes and Adenovirus transcription products that provide helper functions were used to produce pseudotyped recombinant AAV (rAAV) virions. Purification methods generated pseudotyped rAAV virion stocks that were 99% pure with titers of 1×1012-1×1013 vector genomes/ml.

Abstract: A computer network comprising a plurality of computing entities including a dynamic provisioning system that redeploys computer systems between resource groups. The determination as to when this transition between resource groups should occur is based on performance statistics gathered from the network. The transition from one group to the other includes, disabling the computer from a first resource group, reconfiguring the computer according to a configuration database, and redeploying the reconfigured machine to a second resource group. The second resource group can be an over utilized resource group that needs extra compute resources or it can be an idle resource group.

Abstract: A computer system includes a first storage device, a backup storage device, and a system controller. The first storage device has a default operating system and a customized operating system stored therein. The backup storage device has at least archived configuration data stored therein. The system controller is adapted to replace the customized operating system with a restored operating system that is based on the default operating system. A method for restoring a computer system includes providing a first storage device having a default operating system stored therein. A backup storage device is provided having at least configuration data stored therein. The configuration data is transferred to the first storage device.

Abstract: A computer system comprising a plurality of computing entities includes automatic power management logic that automatically transitions the system to a state in which less power is consumed when appropriate. The determination as to when this transition should occur is based on determining when demand for the processing abilities of the system are reduced. Once the decision has been made to transition to a reduced power state, the system's power management logic makes this transition in such a way to preferably minimize or at least reduce the performance impact on the system. Also, rather than altering the power state of one of the computing entities in the system, the entity can be deployed as part of another computing system.

Abstract: A method for undeleting files in a computer system includes flagging at least one deleted file with an identifier. The flagged deleted file is hidden in the computer system. A list of deleted files that have been flagged with the identifier is generated. The list of deleted files is comprised of a directory path hierarchy for each deleted file. A file is selected from the list of deleted files and undeleted.

Abstract: A method for configuring communications settings in a computer system is provided. The method includes receiving a configuration settings file. The configuration settings file includes global connection settings, a connection type, and connection type specific settings. A communications link is configured to address a service provider based on the global settings. An access device in the computer system is configured based on the connection type and the connection type specific settings.

Abstract: Improved techniques for monitoring behavioral data of components of a computer system are disclosed. The monitoring begins to monitor a component once a monitoring program recognizes the presence of the component within the computer system. Then, the monitoring program tracks behavioral data generated by the component. A user interacting with the monitoring program is thus able to monitor the operation of the component by analyzing the various behavioral data it receives from the component. In one embodiment, the component is a hardware resource and its driver sends events to the monitoring program, and the driver receives commands from the monitoring program.

Abstract: A computer system includes error handling hardware and software that logs the source of application program or system software errors before a reset occurs. Upon a catastrophic error, a retriggerable timer, which is periodically retriggered during normal system operation, instead times out causing a hardware reset. A predetermined time before this retriggerable timer times out, however, the microprocessor in the computer system is interrupted, and executes an interrupt routine in which it determines that the retriggerable timer is about to timeout, and logs the currently executing applications program or currently executing point in system software, as well as the actual location within the applications program or the system software. The reset subsequently occurs, but not before this information valuable for debugging and diagnosis is logged.

Abstract: A computer system includes error handling hardware and software that logs the source of application program or system software errors before a reset occurs. Upon a catastrophic error, a retriggerable timer, which is periodically retriggered during normal system operation, instead times out causing a hardware reset. A predetermined time before this retriggerable timer times out, however, the microprocessor in the computer system is interrupted, and executes an interrupt routine in which it determines that the retriggerable timer is about to timeout, and logs the currently executing applications program or currently executing point in system software, as well as the actual location within the applications program or the system software. The reset subsequently occurs, but not before this information valuable for debugging and diagnosis is logged.

Abstract: Computer system which varies the number of read requests outstanding to hard disk drives based on the mix of sequential and random requests. If a sequential request is received, a limited number of requests are allowed to be outstanding. If the requests are random, a growing number of read requests can be outstanding as the random requests continue, until a maximum number of write requests are allowed to be outstanding.