Patents by Inventor Mark R. Prausnitz

Mark R. Prausnitz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210196937
    Abstract: Drug delivery devices and methods are provided for delivering one or more drugs into a biological tissue. The devices include microneedles that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release. Methods for delivery drug with microneedles also are provided.
    Type: Application
    Filed: February 24, 2021
    Publication date: July 1, 2021
    Inventors: Devin V. McALLISTER, Mark R. PRAUSNITZ, Sebastien HENRY
  • Patent number: 10940301
    Abstract: The devices 400, 500 include microneedles 450, 550 that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release.
    Type: Grant
    Filed: April 18, 2016
    Date of Patent: March 9, 2021
    Assignee: Georgia Tech Research Corporation
    Inventors: Devin V. McAllister, Mark R. Prausnitz, Sebastien Henry
  • Publication number: 20210022918
    Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.
    Type: Application
    Filed: October 2, 2020
    Publication date: January 28, 2021
    Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
  • Publication number: 20210016071
    Abstract: A microneedle array is provided for administrating a drug or other substance into a biological tissue. The array includes a base substrate; a primary funnel portion extending from one side of the base substrate; and two or more solid microneedles extending from the primary funnel portion, wherein the two or more microneedles comprise the substance of interest. Methods for making an array of microneedles are also provided. The method may include providing a non-porous and gas-permeable mold having a two or more cavities each of which defines a microneedle; filling the cavities with a fluid material which includes a substance of interest and a liquid vehicle; drying the fluid material to remove at least a portion of the liquid vehicle and form a plurality of microneedles that include the substance of interest, wherein the filling is conducted with a pressure differential applied between opposed surfaces of the mold.
    Type: Application
    Filed: October 1, 2020
    Publication date: January 21, 2021
    Inventors: Devin MCALLISTER, Mark R. PRAUSNITZ, Sebastien HENRY, Xin Dong GUO
  • Publication number: 20200315502
    Abstract: Methods and devices of collecting ISF from skin. The methods may include inserting an array of microneedles into a patients skin to form apertures in the patients skin, facilitating ISF mobilization within the skin, and collecting ISF that flows from the apertures. The devices may include an array of microneedles extending from a backing structure. The devices also may include a collection matrix for collecting ISF and/or means for facilitating ISF mobilization.
    Type: Application
    Filed: December 21, 2018
    Publication date: October 8, 2020
    Inventors: Pradnya Samant, Chandana Kolluru, Mark R. Prausnitz
  • Publication number: 20200238065
    Abstract: Separable microneedle arrays and microneedle patches are provided that may achieve sustained release of drug. The microneedle arrays may include one or more features that facilitate separation of the microneedles, such as a bubble structure. The microneedle arrays may include an effervescent material.
    Type: Application
    Filed: October 11, 2018
    Publication date: July 30, 2020
    Inventors: Mark R. PRAUSNITZ, Richard N. TERRY, Wei LI
  • Patent number: 10632013
    Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.
    Type: Grant
    Filed: September 19, 2017
    Date of Patent: April 28, 2020
    Assignees: GEORGIA TECH RESEARCH CORPORATION, EMORY UNIVERSITY
    Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
  • Publication number: 20200061357
    Abstract: The present disclosure provides methods for administering formulations to the suprachoroidal space of the eye to achieve targeted drug delivery to a desired site of action within the eye. The methods include using a pushing formulation that includes a material such as a gel that expands due to physiochemical cues; or using an electric field to affect the movement of a formulation within the suprachoroidal space; or a combination of a pushing formulation with an electric field.
    Type: Application
    Filed: May 2, 2018
    Publication date: February 27, 2020
    Inventors: Jae Hwan JUNG, Mark R. PRAUSNITZ
  • Publication number: 20190240469
    Abstract: Microneedle patches and systems, and methods for use of such patches and systems. In one aspect, a microneedle patch is provided including a tab portion for handling the microneedle patch. In another aspect, a system is provided including a microneedle patch and a tray for housing the microneedle patch. In still another aspect, various indicators providing for providing feedback prior to, during, and after administration of the microneedle patch are provided. Advantageously, the described microneedle patches and systems provide improved handling and ease of application of the microneedle patches to skin for the delivery of therapeutic agents.
    Type: Application
    Filed: April 15, 2019
    Publication date: August 8, 2019
    Inventors: Devin McAllister, Mark R. Prausnitz, Sebastien Henry, James J. Norman
  • Publication number: 20190240336
    Abstract: Provided herein are fluid formulations for administration to a suprachoroidal space of an eye of a patient. The fluid formulations may include a pharmaceutical agent, a binding molecule, or a combination thereof. The pharmaceutical agent and the binding molecule may be bonded to each other covalently, non-covalently, or a combination thereof. The pharmaceutical agent may be configured to bond to an ocular tissue. The binding molecule may be configured to bond to an ocular tissue. Methods of administering the fluid formulations, methods of expanding a suprachoroidal space, and methods of reducing the minimum force to separate the sclera and choroid are provided.
    Type: Application
    Filed: July 20, 2017
    Publication date: August 8, 2019
    Applicants: Emory University, Georgia Tech Research Corporation
    Inventors: Mark R. Prausnitz, Bryce Chiang
  • Publication number: 20190015651
    Abstract: Provided herein are microneedle particles, compositions that include microneedle particles, methods of treating skin, and methods of delivering a substance of interest. The microneedle particles may include one or more microneedles, and the microneedle particles may be configured to prevent the entire microneedle particle from penetrating the biological tissue. The microneedle particles may be dispersed in a liquid medium to form a composition. A biological tissue may be contacted with the microneedle particles to pre-treat the biological tissue, and a substance of interest may be applied to the pre-treated biological tissue.
    Type: Application
    Filed: March 1, 2017
    Publication date: January 17, 2019
    Inventors: Andrew TADROS, Mark R. PRAUSNITZ
  • Patent number: 10010499
    Abstract: The present invention relates to microneedle vaccine formulations, as well as methods of use thereof to provide animals, including canines, protective immunity against infection and disease caused by rabies viruses. Once placed onto the skin of the animals, the microneedle formulations dissolve quickly into the surrounding skin, where the antigens then elicit in the animals high and protective levels of rabies virus neutralizing antibodies.
    Type: Grant
    Filed: November 3, 2015
    Date of Patent: July 3, 2018
    Assignees: MERIAL INC., Georgia Tech Research Corporation
    Inventors: Yu-Wei Chiang, Mark R. Prausnitz, Kristopher Daniel DeWitt, Jaya Arya
  • Publication number: 20180133447
    Abstract: The devices 400, 500 include microneedles 450, 550 that may be separable from the drug delivery devices, control drug release rate and/or direction, or a combination thereof. When the microneedles are separable, a force applied to the drug delivery devices may be effective to penetrate a biological tissue with the microneedles and then to separate the microneedles from the drug delivery devices. The drug delivery devices may be capable of achieving discrete periods of drug release.
    Type: Application
    Filed: April 18, 2016
    Publication date: May 17, 2018
    Inventors: Devin V. McALLISTER, Mark R. PRAUSNITZ, Sebastien HENRY
  • Publication number: 20180028357
    Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.
    Type: Application
    Filed: September 19, 2017
    Publication date: February 1, 2018
    Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
  • Patent number: 9788995
    Abstract: Methods and devices are provided for targeted administration of a drug to a patient's eye. In one embodiment, the method includes inserting a hollow microneedle into the sclera of the eye at an insertion site and infusing a fluid drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused fluid drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. The fluid drug formulation may flow circumferentially toward the retinochoroidal tissue, macula, and optic nerve in the posterior segment of the eye.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: October 17, 2017
    Assignees: Georgia Tech Research Corporation, Emory University
    Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Samirkumar Rajnikant Patel
  • Publication number: 20170273827
    Abstract: A microneedle has a proximal end portion and a distal end portion and defines a lumen. The proximal end portion is configured to be coupled to a cartridge to place the lumen in fluid communication with the cartridge. The proximal end portion includes a base surface that is configured to be placed in contact with a surface of a target tissue. The distal end portion of the microneedle includes a beveled surface. The beveled surface defines a tip angle of less than about 20 degrees and a ratio of a bevel height to a bevel width of less than about 2.5.
    Type: Application
    Filed: June 9, 2017
    Publication date: September 28, 2017
    Inventors: Mark R. Prausnitz, Henry F. Edelhauser, Vladimir G. Zarnitsyn, Samirkumar R. Patel, Hans Grossniklaus
  • Publication number: 20160310417
    Abstract: Formulations, systems, and methods of administration are provided for preferential targeted delivery of drug to ocular tissue. In embodiments, the formulation may include a non-Newtonian fluid that facilitates targeted localization or preferential spreading of the fluid formulation in the ocular tissue. The fluid formulation may be administered to an eye of a patient by inserting a microneedle into the eye at an insertion site, and infusing a volume of a fluid formulation through the microneedle into the suprachoroidal space of the eye at the insertion site over a first period. During the first period, the fluid formulation may be distributed over a first region which is less than about 10% of the suprachoroidal space, and during the second period subsequent to the first period the drug formulation may be distributed over a second region which is greater than about 20% of the suprachoroidal space.
    Type: Application
    Filed: December 19, 2014
    Publication date: October 27, 2016
    Inventors: Mark R. PRAUSNITZ, Yoo Chun KIM, Henry F. EDELHAUSER
  • Patent number: 9364426
    Abstract: Coated microneedle devices and methods of making such devices are provided. In one aspect, a method for coating includes providing a microstructure having at least one surface in need of coating; and applying a coating liquid, which includes at least one drug, to the at least one surface of the microstructure, wherein the surface energy of the coating liquid is less than the surface energy of the surface of the microstructure. The coating liquid may include a viscosity enhancer and surfactant. Microneedles having heterogeneous coatings, pockets, or both are also provided.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: June 14, 2016
    Assignee: Georgia Tech Research Corporation
    Inventors: Harvinder Singh Gill, Mark R. Prausnitz
  • Publication number: 20160120799
    Abstract: The present invention relates to microneedle vaccine formulations, as well as methods of use thereof to provide animals, including canines, protective immunity against infection and disease caused by rabies viruses. Once placed onto the skin of the animals, the microneedle formulations dissolve quickly into the surrounding skin, where the antigens then elicit in the animals high and protective levels of rabies virus neutralizing antibodies.
    Type: Application
    Filed: November 3, 2015
    Publication date: May 5, 2016
    Applicants: GEORGIA TECH RESEARCH CORPORATION, MERIAL, INC.
    Inventors: Yu-Wei Chiang, Mark R. Prausnitz, Kristopher Daniel DeWitt, Jaya Arya
  • Patent number: 9302903
    Abstract: Microneedle devices and methods of manufacture are provided for transport of molecules or energy across or into biological barriers, such as skin. The device can comprise one or more microneedles formed of a first material and a second material, wherein the second material is dispersed throughout the first material or forms a portion of the microneedle. The first material preferably is a polymer. The second material can be pore forming agents, structural components, biosensor, or molecules for release, such as drug. The device also can comprise a substrate and a plurality of microneedles extending from the substrate, wherein the microneedles have a beveled or tapered tip portion, a longitudinally extending exterior channel, or both. Methods of making these devices include providing a mold having a plurality of microdepressions which define the surface of a microneedle; filling the microdepressions with a first molding material; and molding the material, thereby forming microneedles.
    Type: Grant
    Filed: December 14, 2001
    Date of Patent: April 5, 2016
    Assignee: Georgia Tech Research Corporation
    Inventors: Jung-Hwan Park, Mark R. Prausnitz