Abstract: The invention provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumor cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.

Abstract: The invention provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof and further provides a method of treating or inhibiting the growth of cancerous tumour cells and associated diseases in a mammal in need thereof by interacting with tubulin and microtubules and promoting microtubule polymerization which comprises administering to said mammal an effective amount of a substituted triazolopyrimidine derivative or a pharmaceutically acceptable salt thereof.

Abstract: A template system enables an installer to mark a plurality of bricks laid in a pattern to define a desired edge shape of the bricks. The template system includes a flexible tool which provides a surface against which a marking tool can be placed, and a plurality of anchors. Each anchor is attached to at least one brick and is removable therefrom. In use, the anchors are attached to the bricks. The tool is then attached to the anchors such that the desired shape is provided. Thereafter, the marking tool is run along the length of the tool to mark the desired shape onto the bricks. The tool and anchors are removed and the bricks are then cut by suitable means so that the desired border or edge shape is formed.

Abstract: The present invention provides a novel template which allows an installer to easily and quickly form accurate markings on a concrete brick so that the brick can be cut in a precise manner to be used in a driveway pattern, a sidewalk pattern, or the like. The template includes a frame and a planar plate. The plate has a plurality of slots formed therethrough. The template is positioned on a brick such that the plate sits on the top of the brick and the frame abuts against the sides of the brick. The installer then uses a marking tool to mark the desired cut or cuts by running the tool along the length of one slot or the slots. The template is then removed and the brick is cut accordingly.

Abstract: This invention pertains to methods for using oxalate oxidase in plant pathology. A substantially pure gene encoding the oxalate oxidase enzyme is elucidated. The expression product of the gene which can be stably incorporated into a foreign plant host has a unique profile including a pH optimum of 3.5, a positive heat stability, a single sub-unit of approximately 25 kilodaltons and protease stability. The methodology of this invention exploiting oxalate oxidase for protection against oxalic acid encompasses providing to a plant in need of oxalic acid protection an oxalic acid degrading enzyme in an amount sufficient to protect the plant from the oxalic acid.