Abstract: Systems and methods separate pump the blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods can employ a fixture to restrain expansion of the flexible filter housing during operation of the pump.

Abstract: Systems and methods separate pump the blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods can employ a fixture to restrain expansion of the flexible filter housing during operation of the pump.

Abstract: A multiple function pump station performs different on-line processing tasks. The pump station can be operated in one mode to draw blood from a donor can, in another mode, be operated to return blood to the donor. The pump station used to draw blood from a donor can also be used to perform subsequent blood processing tasks, such as mixing processing or additive fluids with the blood, or transfering a harvested blood component to a storage container, or finishing the processing of a harvested blood component, e.g., by passage through a filter to remove leukocytes.

Abstract: Systems and methods separate pump the blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter has a filtration medium enclosed within a flexile housing. The systems and methods can employ a fixture to restrain expansion of the flexible filter housing during operation of the pump.

Abstract: Blood processing systems and related methods place first and second fluid pressure actuated pump stations in in-line communication between a source and a destination. The systems and methods apply fluid pressure pump strokes to the first and second pump stations to convey fluid from the source to the destination. The systems and methods switch between a first flow mode and a second flow mode. In the first flow mode, the pump strokes draw a fluid volume into the first pump station from the source and expel a fluid volume from the second pump station to the destination. In the second flow mode, the pump strokes draw a fluid volume into the second pump station from the source and expel a fluid volume from the first pump station to the destination. The systems and methods synchronize the pump strokes so that fluid flow from the source is essentially continuous while fluid flow to the destination is pulsatile.

Abstract: A blood processing system comprises a processing chamber to process blood and a fluid flow cassette that communicates with the processing chamber. The cassette comprises a body, a pump chamber formed in the body, and a flexible diaphragm on the pump chamber responsive to an applied fluid pressures for flexure toward and away from the pump chamber to pump fluid through the pump chamber. The cassette also includes a flow path formed, at least in part, in the body to couple the pump chamber in fluid flow communication with the processing chamber, to convey fluid pumped by the pump chamber into the processing chamber. The cassette also includes an in line cavity formed in the body and located in the flow path to trap air to prevent entry of air into the processing chamber.

Abstract: A connector for joining two parts of a medical product, where the parts are sterilized by different forms of sterilization, is disclosed. The connector includes a generally tubular body having a first end adapted for connection to a part of the medical product, another closed, but openable end, and an expansion chamber of one-piece integral construction with the tubular body.

Abstract: A blood processing system comprises a processing chamber to process blood and a fluid flow cassette that communicates with the processing chamber. The cassette comprises a body, a pump chamber formed in the body, and a flexible diaphragm on the pump chamber responsive to an applied fluid pressures for flexure toward and away from the pump chamber to pump fluid through the pump chamber. The cassette also includes a flow path formed, at least in part, in the body to couple the pump chamber in fluid flow communication with the processing chamber, to convey fluid pumped by the pump chamber into the processing chamber. The cassette also includes an in line cavity formed in the body and located in the flow path to trap air to prevent entry of air into the processing chamber.

Abstract: Red blood cell sensing systems and methods rely upon straightforward measurement geometries. the systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.

Abstract: A cassette for directing fluid flow, comprising a body and a valve chamber formed in the body, provides a centralized, programmable, and integrated platform to carry out diverse and coordinated pumping and valving functions, e.g., such as required for blood processing.

Abstract: A pneumatic pump manifold disposable system, configured as a cassette, is used for the purpose of red cell and plasma apheresis. The cassette integrates a separation device, manifold system, macro-aggregate filter, and five pumping chambers for the purpose of separating plasma and red cells from the whole blood. The cassette system, with the separation device directly attached without tubing, simplifies the loading of the disposable set into the hardware, and reduces the manufacturing complexity of the set. The system allows for plasma, plasma and red cells, or just red cells to be stored in long term storage containers after a procedure.

Abstract: Blood processing systems and methods convey blood cells from a blood cell source into a blood component collection flow channel that includes a blood cell storage container and an in-line filter to remove leukocytes from blood cells before entering the blood cell storage container. The systems and methods also convey additive solution from an additive solution source into the blood component collection flow channel. The systems and methods alternate the conveyance of blood cells through the filter with the conveyance of additive solution through the filter.

Abstract: A yoke rotates an umbilicus about a rotational axis, which, in turn, imparts rotation to a blood processing chamber coupled to the umbilicus. The yoke carries first and second umbilicus support surfaces that inhibit travel of the umbilicus in radial directions toward and away from the rotational axis.

Abstract: Red blood cell sensing systems and methods rely upon straightforward measurement geometries. The systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.

Abstract: Systems and methods separate blood cells from whole blood and pump the separated blood cells through an in-line leukofilter to a blood cell storage container. The leukofilter comprises a filtration medium enclosed within a flexile housing. The systems and methods include a fixture to restrain expansion of the flexible filter housing during operation of the pump. The fixture includes a bracket to enable its releasable attachment to the blood processing device employed to carry out the separation process.

Abstract: Blood processing systems and methods employ two sensors, one to detect a condition of plasma exiting a separation device and another sensor to detect a condition of a cellular component exiting the separation device. The first sensor detects, e.g., contamination of the plasma due to presence of unwanted cellular components. The second sensor detects, e.g., dilution of the cellular component due to presence of plasma. Blood processing parameters are carried out based, at least in part, by conditions detected by one or both of the sensors.

Abstract: Red blood cell sensing systems and methods rely upon straightforward measurement geometries. the systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.

Abstract: Red blood cell sensing systems and methods rely upon straightforward measurement geometries. The systems and methods comprise an incident light source, an optical sensor, and a blood collection tube. The systems and methods hold the blood collection tube a predetermined radial distance from the incident light source where a linear relationship exists between sensed reflected light measured by the optical sensor and red blood cell hematocrit in a range of at least 10 to 90. The systems and methods make possible accurate red blood sensing without use of special optical cuvettes, mirrors, or focusing lenses. The systems and methods also make possible the use of standard transparent plastic tubing, without reliance upon special optical cuvettes.

Abstract: A fluid processing assembly is used in association with a cassette that conveys fluid and a holder to hold the cassette. A door is carried by the holder for movement between an opened position to expose the holder and a closed position enclosing the cassette in the holder. The door carries an expandable gasket. The expandable gasket normally rests, when the door is in the closed position, in a relaxed state out of sealing contact with the held cassette. An actuator applies pressure to the expandable gasket to achieve, when the door is in the closed position, an expanded state in sealing contact against the held cassette. The assembly also includes a latch assembly on the door and holder, which makes engagement when the door is in the closed position. The engagement is unlocked when the gasket rests in the relaxed state. The engagement becomes locked when the gasket achieves the expanded state.

Abstract: A drip chamber includes a cap that extends the field of view of a droplet in a vertical direction above the plane of the droplet, as well as horizontally in the plane of the droplet. The drip chamber has a deformable body and an interior volume to accommodate manual air purging and priming by squeezing the body.