Patents by Inventor Mark R. Witmer

Mark R. Witmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified inosine 5'-monophosphate dehydrogenase polypeptides and uses thereof
    Publication number: 20020068346
    Abstract: The present invention provides isolated modified inosine 5′-monophosphate dehydrogenase (IMPDH) polypeptides. These modified IMPDH polypeptides comprise a substitute oligo-peptide that replaces the subdomain region. The modified polypeptides of the invention bind to an inhibitor, such as MPA, and/or exhibit functional activity of wild-type IMPDH holo-enzyme.
    Type: Application
    Filed: May 10, 2001
    Publication date: June 6, 2002
    Inventors: Stanley R. Krystek, Steven Sheriff, Mark R. Witmer, Diane L. Hollenbaugh, Ning Yan, Julie E. Mouravieff, Howard M. Einspahr, Kevin Kish