Abstract: The invention is directed to treatment or prevention of a disease characterized by deposition of A? in the brain using anti-A? antibodies. The diseases that can be treated or prevented include, e.g., Alzheimer's disease, Down's syndrome, and cerebral amyloid angiopathy. The invention is also related to, in some aspects, to selecting a human subject based on the tau burden in the human subjects' brain, who is responsive to treatment or prevention of a disease characterized by deposition of A? in the brain that includes administering anti-A? antibodies. The invention is also related to human subjects who have one or two alleles of APOE e4.

Abstract: The present disclosure relates to IL-34 antibodies, compositions comprising the same, and methods of using the antibodies and or compositions thereof for treating immune-mediated diseases such as neurodegenerative diseases, for example Alzheimer's Disease or a tauopathy disease.

Abstract: A Sender Controlled Media (SCM) platform user is presented incentives for performing rewardable platform activities that result in accruing points in a user-specific account from which points can be redeemed by transfer or cryptocurrency conversion to an external user-designated wallet. A reward received for each instance of a rewardable platform activity is determined based on a range of platform context including a target average points payout, an aggregated total points payout over a distribution period, and a type of rewardable platform activity.

Abstract: An irrigation system having a pipeline supported by one or more towers includes an improved truss connection system having a means for readily adjusting a crown height of the pipeline. A pair of cooperating members define a joint which selectively couples headed ends of adjacent truss rods together to form a truss rail of a truss system that supports the pipeline. A single fastener may fasten the cooperating members, a strut, and a cross-member together at the joint. A length of the truss rail may be decreased by holding the truss rods closer together. In an aspect, the headed ends of the adjacent truss rods are held closer together by inserting a shim in one of the joints. Decreasing the length of the truss rail increases the deflection of the pipeline and raises the crown height.

Abstract: An irrigation system having a pipeline supported by one or more towers includes an improved truss connection system having a means for readily adjusting a crown height of the pipeline. A pair of cooperating members define a joint which selectively couples headed ends of adjacent truss rods together to form a truss rail of a truss system that supports the pipeline. A single fastener may fasten the cooperating members, a strut, and a cross-member together at the joint. A length of the truss rail may be decreased by holding the truss rods closer together. In an aspect, the headed ends of the adjacent truss rods are held closer together by inserting a shim in one of the joints. Decreasing the length of the truss rail increases the deflection of the pipeline and raises the crown height.

Abstract: An irrigation system having a pipeline supported by one or more towers includes an improved truss connection system having a means for readily adjusting a crown height of the pipeline. A pair of cooperating members define a joint which selectively couples headed ends of adjacent truss rods together to form a truss rail of a truss system that supports the pipeline. A single fastener may fasten the cooperating members, a strut, and a cross-member together at the joint. A length of the truss rail may be decreased by holding the truss rods closer together. In an aspect, the headed ends of the adjacent truss rods are held closer together by inserting a shim in one of the joints. Decreasing the length of the truss rail increases the deflection of the pipeline and raises the crown height.

Abstract: The present invention relates to methods and apparatus that can be used for efficient end-of-line (EOL) testing of electrochemical stacks once they are assembled, and prior to break-in or operation of the stack. Rapid test methods and test methods that can be performed in parallel to detect different types of defects are described. Embodiments of the methods and apparatus can be used for testing PEM fuel cell stacks and electrolyzers.

Abstract: An irrigation system having a pipeline supported by one or more towers includes an improved truss connection system having a means for readily adjusting a crown height of the pipeline. A pair of cooperating members define a joint which selectively couples headed ends of adjacent truss rods together to form a truss rail of a truss system that supports the pipeline. A single fastener may fasten the cooperating members, a strut, and a cross-member together at the joint. A length of the truss rail may be decreased by holding the truss rods closer together. In an aspect, the headed ends of the adjacent truss rods are held closer together by inserting a shim in one of the joints. Decreasing the length of the truss rail increases the deflection of the pipeline and raises the crown height.

Abstract: An irrigation system having a pipeline supported by one or more towers includes an improved truss connection system having a means for readily adjusting a crown height of the pipeline. A pair of cooperating members define a joint which selectively couples headed ends of adjacent truss rods together to form a truss rail of a truss system that supports the pipeline. A single fastener may fasten the cooperating members, a strut, and a cross-member together at the joint. A length of the truss rail may be decreased by holding the truss rods closer together. In an aspect, the headed ends of the adjacent truss rods are held closer together by inserting a shim in one of the joints. Decreasing the length of the truss rail increases the deflection of the pipeline and raises the crown height.

Abstract: A mobile container that is designed to allows a user to easily transport the container through a variety of terrains, such as snow, sand, and pavement. The mobile container includes an insulated container, a first sled-molded runner, a second sled-molded runner, a first wheel, a second wheel, and a convex protrusion. The first sled-molded runner and the second sled-molded runner are positioned parallel and opposite to each other, across the insulated container, and are adjacently connected to a base of the insulated container. The first wheel and the second wheel are laterally and coaxially connected to the insulated container, opposite to each other. The convex protrusion modifies the flow of sand or snow about the insulated container in order to decrease drag. The convex protrusion is positioned opposite the first wheel and the second wheel. Additionally, the convex protrusion is integrated into a front surface of the insulated container.

Abstract: A Sender Controlled Media (SCM) platform user is presented incentives for performing rewardable platform activities that result in accruing points in a user-specific account from which points can be redeemed by transfer or cryptocurrency conversion to an external user-designated wallet. A reward received for each instance of a rewardable platform activity is determined based on a range of platform context including a target average points payout, an aggregated total points payout over a distribution period, and a type of rewardable platform activity.

Abstract: Methods and apparatus for detecting electrical short circuits in fuel cell stacks are provided. The methods involve supplying a reactant and an inert gas to a fuel cell stack and measuring the open circuit voltage of fuel cell assemblies in the fuel cell stack. The sensitivity of the methods can be adjusted to detect an electrical short circuit having a resistance at or below a particular threshold short-circuit resistance value, by using a suitable reactant concentration in the method. The methods can include determining a set-point reactant concentration that can be used to detect an electrical short circuit having a resistance at or below a particular threshold short-circuit resistance value.

Abstract: A greaseless pivot center swivel and bearing device includes an outer housing having a sidewall with top and bottom portions, a top plate coupled with the top portion that includes an opening therein, and a bottom plate coupled with the bottom portion that includes an opening therein. The sidewall cooperates with the top and bottom plates to define an interior volume. A single, unitary bushing member formed of a low-friction material is positioned within the interior volume and includes a surface cylindrically curved about an axis extending between the top and bottom plates of the housing. The cylindrically curved surface cooperates with the openings in the top and bottom plates to define a cylindrical passage through the interior volume sized and shaped for receiving a cylindrical tube that rotates therein, e.g., a tube configured to connect with a water supply column of a mechanized irrigation system.

Abstract: A greaseless pivot center swivel and bearing device includes an outer housing having a sidewall with top and bottom portions, a top plate coupled with the top portion that includes an opening therein, and a bottom plate coupled with the bottom portion that includes an opening therein. The sidewall cooperates with the top and bottom plates to define an interior volume. A single, unitary bushing member formed of a low-friction material is positioned within the interior volume and includes a surface cylindrically curved about an axis extending between the top and bottom plates of the housing. The cylindrically curved surface cooperates with the openings in the top and bottom plates to define a cylindrical passage through the interior volume sized and shaped for receiving a cylindrical tube that rotates therein, e.g., a tube configured to connect with a water supply column of a mechanized irrigation system.

Abstract: A Sender Controlled Media (SCM) platform user is presented incentives for performing rewardable platform activities that result in accruing points in a user-specific account from which points can be redeemed by transfer or cryptocurrency conversion to an external user-designated wallet. A reward received for each instance of a rewardable platform activity is determined based on a range of platform context including a target average points payout, an aggregated total points payout over a distribution period, and a type of rewardable platform activity.

Abstract: A business application that includes a workflow for handling a call is adapted to perform a call service selected from a library of Sender Controlled Media business application services by configuring at least one service from the library for operation with the business application and utilizing the adapted business application to handle calls per the workflow.

Abstract: Automated dialing of an entity from a curated list of entities responsive to user selections of dial pad entries, the curated list of entities formed from phrases formed from the dial pad entries. The curated list of entities is based on at least one of user call activity, search engine activity responsive to the phrases, a set of Sender Controlled Media participants, a set of categories of contacts, and entity offerings.

Abstract: A call handling function executed in response to activation of a link in encoded metadata of an incoming call adjusts presentation of visual content of the incoming call on a lockscreen of a smart phone based on information in the metadata that is descriptive of the incoming call. The incoming call metadata is decoded prior to connecting the incoming call to a dialer function of the smart phone.

Abstract: Conditionally connecting a smart phone to an incoming call based on user interaction with an incentive offer associated with the call that is presented in an incoming call display on a lockscreen of the smart phone. A dialer controlling the incoming call display accesses the incentive offer through a visual portion of a Sender Controlled Media data structure. The dialer can adjust the incentive offer based on user interaction with the incoming call display.