Abstract: A nuclear reactor core includes a plurality of fuel elements and moderator blocks to form a nuclear reactor core inner portion and a nuclear reactor core outer portion. The nuclear reactor core inner portion includes an inner moderator matrix formed of a plurality of inner holes that include a plurality of inner fuel openings with one or more fuel elements disposed therein. The plurality of inner holes further include a plurality of inner coolant passages to flow a coolant. The nuclear reactor core outer portion includes an outer moderator matrix formed of a plurality of outer holes that include a plurality of outer fuel openings with one or more fuel elements disposed therein. The plurality of outer holes further include a plurality of outer coolant passages to flow the coolant. The outer coolant passage diameter exceeds the inner coolant passage diameter.

Abstract: The present invention provides devices comprising multimodal depth electrodes for real-time quantification of chemistry and electrophysiology of the body. The devices are useful in several applications, including monitoring primary and secondary brain injury. The multimodal depth electrodes electrically transduce signals from biological parameters of interest, including EEG, temperature, pressure, oxygen level, blood flow, and chemistry.

Abstract: A system includes a pipetting system including a 3-axis gantry; a sled mechanism to select a magnetic comb from a set of magnetic combs; a fluorometer; and a set of receptacles to receive welled plates. A method for purifying nucleic acids includes applying a sample to a well of a multi-well plate, selecting a magnetic comb from a set of magnetic combs disposed on a gantry system, collecting magnetic beads using the magnetic comb, collecting nucleic acid using the magnetic beads, and eluting the nucleic acid from the beads.

Abstract: A container includes a lower portion and a lid to connect with the lower portion. The lid includes a fluidic interface, a swing bar, and a counter structure disposed on an opposite side of the fluidic interface relative to the swing bar. The fluidic interface includes a first liquid port, a second liquid port, a gas port, and a seal ring disposed around the first liquid port, the second liquid port, and the gas port, the first liquid port disposed along a center axis of the container.

Abstract: A system includes a pipetting system including a 3-axis gantry; a sled mechanism to select a magnetic comb from a set of magnetic combs; a fluorometer; and a set of receptacles to receive welled plates. A method for purifying nucleic acids includes applying a sample to a well of a multi-well plate, selecting a magnetic comb from a set of magnetic combs disposed on a gantry system, collecting magnetic beads using the magnetic comb, collecting nucleic acid using the magnetic beads, and eluting the nucleic acid from the beads.

Abstract: An oxygen sensor device comprises a Clark-type sensor electrode comprising thin-film electrode leads overlaid with a solid-state proton conductive matrix (PCM) wherein at least one dimension of the electrode is less than 25 ?m. An oxygen sensor system comprises an oxygen sensor device, a sensing window above the electrode, at least one contact pad, and at least one lead line electrically connecting the at least one contact pad to the oxygen sensor electrode. Methods of oxygen sensing are also disclosed.

Abstract: A sensor device includes a substrate having a die attached to the substrate. The die includes an array of sensors and an array of wells cooperatively disposed over the array of sensors. The array of wells is exposed by the substrate. The sensor device further includes a flow cell secured to the substrate and defining a flow space disposed over the die and accessible to the array of wells. The flow cell defines a plurality of separate volumes. Each separate volume of the plurality of separate volumes has an inlet and an outlet. The plurality of separate volumes are separated by dividers. The dividers cover a set of wells of the array of wells.

Abstract: Systems and methods as disclosed herein automatically provide real-time dosing corrections for an industrial process wherein enzyme blends are applied to natural fibers for pulp/paper production. An initial enzyme blend (e.g., enzymes and supporting formulation components, as relevant) and respective dose rates are selected to be applied based on expected fiber surface substrate characterization, expected fiber quality characterization, the physical conditions of the system being treated, respective characteristics of the initially selected enzyme blend components, etc. Upon application of the initial enzyme blend, online sensors provide real-time feedback data corresponding to measured actual values for the fiber surface substrate characterization and fiber quality characterization. A replacement enzyme blend (enzymes and supporting formulation components) and respective dose rates thereof is dynamically selected based on the feedback data.

Abstract: A method of applying a fluid composition to a flow cell of a sensor device includes inserting the sensor device into a holder; pipetting an aliquot of the fluid composition into a pipette tip; and applying the aliquot of the fluid composition to an opening of a fluidic connector engaged with the flow cell of the sensor device. The fluidic connector includes a body; and a plurality of fluidics interfaces formed in the body, each fluidic interface of the plurality of fluidics interfaces includes an opening, a first port in fluid communication with the opening, a second port, and a third port in fluidic communication with the second port.

Abstract: Systems and methods as disclosed herein automatically provide real-time dosing corrections for an industrial process wherein enzyme blends are applied to natural fibers for pulp/paper production. An initial enzyme blend (e.g., enzymes and supporting formulation components, as relevant) and respective dose rates are selected to be applied based on expected fiber surface substrate characterization, expected fiber quality characterization, the physical conditions of the system being treated, respective characteristics of the initially selected enzyme blend components, etc. Upon application of the initial enzyme blend, online sensors provide real-time feedback data corresponding to measured actual values for the fiber surface substrate characterization and fiber quality characterization. A replacement enzyme blend (enzymes and supporting formulation components) and respective dose rates thereof is dynamically selected based on the feedback data.

Abstract: A cartridge includes a housing having first and second major surfaces and defining a guide mechanism; and a plurality of containers disposed in the housing, each container of the plurality of containers having a receptacle and a lid, the lid formed of a clip and a seal, the clip to secure the seal to the receptacle, a frit disposed in the receptacle in an enclosed space defined by the receptacle and the seal, the seal having an inlet and an outlet in fluid communication with an enclosed space, the frit including a nucleotide concentrate.

Abstract: A fluidic coupler to engage a plurality of flow cells of a sensor device includes a body and a plurality of fluidics interfaces formed in the body. Each fluidic interface of the plurality of fluidics interfaces includes an opening, a first port in fluid communication with the opening, a second port, and a third port in fluidic communication with the second port.

Abstract: A container includes a lower portion and a lid to connect with the lower portion. The lid includes a fluidic interface, a swing bar, and a counter structure disposed on an opposite side of the fluidic interface relative to the swing bar. The fluidic interface includes a first liquid port, a second liquid port, a gas port, and a seal ring disposed around the first liquid port, the second liquid port, and the gas port, the first liquid port disposed along a center axis of the container.

Abstract: Systems and methods as disclosed herein automatically provide real-time dosing corrections for an industrial process wherein enzyme blends are applied to natural fibers for pulp/paper production. An initial enzyme blend (e.g., enzymes and supporting formulation components, as relevant) and respective dose rates are selected to be applied based on expected fiber surface substrate characterization, expected fiber quality characterization, the physical conditions of the system being treated, respective characteristics of the initially selected enzyme blend components, etc. Upon application of the initial enzyme blend, online sensors provide real-time feedback data corresponding to measured actual values for the fiber surface substrate characterization and fiber quality characterization. A replacement enzyme blend (enzymes and supporting formulation components) and respective dose rates thereof is dynamically selected based on the feedback data.

Abstract: A sequencing system includes an automated sequencing instrument adapted to determine variant calls for one or more extracted polynucleotide samples with a performance of at least 98.5% raw read accuracy and a run time in a range of 5 hours to 14 hours to determine variant calls for 4 extracted polynucleotide samples using a targeted assay with one DNA pool per sample and an average amplicon size in a range of 100 to 120 bases.

Abstract: In an example, a method for preparing a nucleotide solution includes flowing an aqueous solution from an initial solution storage of a sequencing instrument continuously through a container fluidically coupled to the sequencing instrument, the container comprising a nucleotide concentrate; and collecting the aqueous solution with nucleotide in a storage container.

Abstract: A container includes a lower portion and a lid to connect with the lower portion. The lid includes a fluidic interface, a swing bar, and a counter structure disposed on an opposite side of the fluidic interface relative to the swing bar. The fluidic interface includes a first liquid port, a second liquid port, a gas port, and a seal ring disposed around the first liquid port, the second liquid port, and the gas port, the first liquid port disposed along a center axis of the container.

Abstract: A sequencing system includes an automated sequencing instrument adapted to determine variant calls for one or more extracted polynucleotide samples with a performance of at least 98.5% raw read accuracy and a run time in a range of 5 hours to 14 hours to determine variant calls for 4 extracted polynucleotide samples using a targeted assay with one DNA pool per sample and an average amplicon size in a range of 100 to 120 bases.

Abstract: A fluidic coupler to engage a plurality of flow cells of a sensor device includes a body and a plurality of fluidics interfaces formed in the body. Each fluidic interface of the plurality of fluidics interfaces includes an opening, a first port in fluid communication with the opening, a second port, and a third port in fluidic communication with the second port.

Abstract: An apparatus includes a fluidic coupler including an opening. A first port is in fluid communication with the opening and is to interface with an inlet of a flow cell of a sensor device. A second port is to interface with an outlet of the flow cell of the sensor device. A third port is in fluidic communication with the second port. The apparatus further includes a mechanical assembly moveable between a first position and a second position. The fluidic coupler is secured to the flow cell of the sensor device in the first position. The fluidic coupler is disengaged from the flow cell of the sensor device in the second position.