Abstract: A reaming device including reamers that are prevented from cutting until the reaming device encounters a wellbore restriction, such as a restricted diameter of the wellbore or a ledge. The reamers are shielded in the reaming device's default position until the device is activated by a wellbore restriction, thereby moving the device into the activated position in which the reamers are allowed to cut or clean the wellbore. The reaming device of the present invention is passively activated; no communication with the surface is necessary for activation.

Abstract: The present disclosure relates to a breathing circuit and a method for providing respiratory support to a patient. The breathing circuit and method can be used in any type of breathing therapy including, for example unsealed respiratory therapy such as high flow therapy, and scaled respiratory therapy such as continuous positive air(way) pressure (CPAP) therapy, and bilevel positive air pressure therapy where the inspiratory and expiratory pressures differ. The breathing circuit includes first and second passageways that can convey a breathing gas to a patient interface, wherein the first passageway is connectable to a first gas source to supply a first gas, and the second passageway is connectable to the first gas source and to a second gas source.

Abstract: The present disclosure relates to a positive pressure breathing circuit and a method for ventilating a patient. The breathing circuit can be used in any type of pressurized breathing therapy including, for example, continuous positive air (way) pressure (CPAP) therapy and bilevel positive air pressure therapy where the inspiratory and expiratory pressures differ.

Abstract: Systems and methods are disclosed for air flow optimization. In certain embodiments, the technology is a system comprising sensors, injectors, actuators, and a system processor. In order to optimize the air flow, the system processor directs the injectors to expel aerosol particles into an environment, such that the aerosol particles can be measured by the one or more sensors. Flow intensity map generation is then used to map the aerosol particles and air flow is changed to optimize aerosol particle concentration using the actuators.

Abstract: Systems and methods are disclosed for air flow optimization. In certain embodiments, the technology is a system comprising sensors, injectors, actuators, and a system processor. In order to optimize the air flow, the system processor directs the injectors to expel aerosol particles into an environment, such that the aerosol particles can be measured by the one or more sensors. Flow intensity map generation is then used to map the aerosol particles and air flow is changed to optimize aerosol particle concentration using the actuators.

Abstract: Embodiments of the present disclosure include a dialysis system having a disposable cartridge which includes one or more flowpaths arranged on or within the cartridge.

Abstract: Embodiments of the present disclosure include a dialysis system having a disposable cartridge which includes one or more flowpaths arranged on or within the cartridge, where the one or more flowpaths including at least one of a blood flowpath for carrying a volume of blood to be treated in a dialyser and a dialysate flowpath, isolated from the blood flowpath, for delivering a flow of dialysate solution through the dialyser.

Abstract: A vacuum cleaner comprises a housing and a motor fan assembly arranged to generate an air flow. A detachable dirt container is mountable to the housing and the dirt container has a dirty air inlet in fluid communication with the motor fan assembly. A filter is for separating dirt from the air flow and the filter is mounted between the dirt container and the motor fan assembly. Wherein the detachable dirt container comprises an emptying aperture in a wall of the dirt container, the emptying aperture being downstream in the air flow from the dirty air inlet and upstream of the filter. Wherein the housing comprises an overlap portion for covering the emptying aperture in the dirt container and sealing the emptying aperture when the detachable dirt container is mounted to the housing.

Abstract: A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dialysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.

Abstract: A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dialysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.

Abstract: A vacuum cleaner comprises a housing and a motor fan assembly arranged to generate an air flow. A detachable dirt container is mountable to the housing and the dirt container has a dirty air inlet in fluid communication with the motor fan assembly. A filter is for separating dirt from the air flow and the filter is mounted between the dirt container and the motor fan assembly. Wherein the detachable dirt container comprises an emptying aperture in a wall of the dirt container, the emptying aperture being downstream in the air flow from the dirty air inlet and upstream of the filter. Wherein the housing comprises an overlap portion for covering the emptying aperture in the dirt container and sealing the emptying aperture when the detachable dirt container is mounted to the housing.

Abstract: A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dialysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.

Abstract: A banked purification system having, in flow series, an inlet for entry of a fluid, a bank of two or more purification columns in which the fluid is purified by a purifying component, and an outlet for discharging the purified fluid, the columns being arranged in parallel such that the fluid from the inlet splits at first ends of the columns into respective streams which flow through the columns and recombine at second ends of the columns for onward travel to the outlet; wherein the columns have first ports in the side walls of the columns at the first ends, the first ports being connected to each other such that the first ends are placed in fluid communication to create a manifold from the first ends of the columns which splits the fluid from the inlet into said streams.

Abstract: A banked purification system having, in flow series, an inlet for entry of a fluid, a bank of two or more purification columns in which the fluid is purified by a purifying component, and an outlet for discharging the purified fluid, the columns being arranged in parallel such that the fluid from the inlet splits at first ends of the columns into respective streams which flow through the columns and recombine at second ends of the columns for onward travel to the outlet; wherein the columns have first ports in the side walls of the columns at the first ends, the first ports being connected to each other such that the first ends are placed in fluid communication to create a manifold from the first ends of the columns which splits the fluid from the inlet into said streams.

Abstract: A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dialysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.

Abstract: A disposable cartridge for use in a hemodialysis machine has a blood flow path for carrying a volume of blood to be treated in a dialyser and a dialysate flow path, isolated from the blood flow path, for delivering a flow of dislysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.

Abstract: A new method of making self-assembled nanoparticle wires involves: (1) at about ambient temperature and at or near atmospheric pressure, immersing a hydrophilic solid substrate at a non-horizontal angle (e.g.

Abstract: A disposable cartridge for use in a hemodialysis machine has a blood flowpath for carrying a volume of blood to be treated in a dialyseer and a dialysate flowpath, isolated from the blood flowpath, for delivering a flow of dislysate solution through the dialyser. The cartridge is received in an engine section of the machine. The engine section has first and second platens which close when the cartridge is inserted to retain the cartridge. Actuators and sensors arranged on the second platen control operation of the cartridge.

Abstract: Recombinant dendritic cells are made by transforming a stem cell and differentiating the stem cell into a dendritic cell. The resulting dendritic cell is an antigen presenting cell which activates T cells against MHC class I-antigen targets. Kits, assays and therapeutics are based upon the activation of T cells by the recombinant dendritic cell. Cancer, viral infections and parasitic infections are all ameliorated by the recombinant dendritic cells, or corresponding activated T cells. Therapeutic compositions and pharmaceutical compositions are provided.

Abstract: A new method of making self-assembled nanoparticle wires involves: (1) at about ambient temperature and at or near atmospheric pressure, immersing a hydrophilic solid substrate at a non-horizontal angle (e.g.