Patents by Inventor Mark Renshaw

Mark Renshaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Engineered plasmids and their use for in situ production of genes
    Publication number: 20090011471
    Abstract: Nucleic acid sequences encoding at least a portion of a polypeptide are directly incorporated into a plasmid by DNA polymerization or reverse transcription of a nucleic acid template. In particularly preferred embodiments, nucleic acid sequences encoding at least a portion of an antibody are directly incorporated into a plasmid by reverse transcription of messenger RNA (mRNA).
    Type: Application
    Filed: June 12, 2007
    Publication date: January 8, 2009
    Inventors: Katherine S. Bowdish, Shana Frederickson, Ying-Chi Lin, Mark Renshaw, Martha Wild, John McWhirter
  • Engineered templates and their use in single primer amplification
    Patent number: 7414111
    Abstract: Methods of amplifying nucleic acid have now been discovered which include the steps of: a) annealing a primer to a template nucleic acid sequence, the primer having a first portion which anneals to the template and a second portion of predetermined sequence; b) synthesizing a polynucleotide that anneals to and is complementary to the portion of the template between the location at which the first portion of the primer anneals to the template and the end of the template, the polynucleotide having a first end and a second end, wherein the first end incorporates the primer; c) separating the polynucleotide synthesized in step (b) from the template; d) annealing a nested oligonucleotide to the second end of the polynucleotide synthesized in step (b), the nested oligonucleotide having a first portion that anneals to the second end of the polynucleotide and a second portion having the same predetermined sequence as the second portion of the primer; e) extending the polynucleotide synthesized in step (b) to provide
    Type: Grant
    Filed: December 15, 2003
    Date of Patent: August 19, 2008
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Toshiaki Maruyama, Katherine S. Bowdish, Shana Frederickson, Mark Renshaw
  • Rationally designed antibodies
    Patent number: 7396917
    Abstract: Antibodies or fragments thereof having at least two CDR regions replaced or fused with biologically active peptides are described. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities.
    Type: Grant
    Filed: December 2, 2002
    Date of Patent: July 8, 2008
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Katherine S. Bowdish, Shana Frederickson, Mark Renshaw
  • Engineered templates and their use in single primer amplification
    Patent number: 7306906
    Abstract: Methods of amplifying nucleic acid have now been discovered which include the steps of: a) annealing a primer to a template nucleic acid sequence, the primer having a first portion which anneals to the template and a second portion of predetermined sequence; b) synthesizing a polynucleotide that anneals to and is complementary to the portion of the template between the location at which the first portion of the primer anneals to the template and the end of the template, the polynucleotide having a first end and a second end, wherein the first end incorporates the primer; c) separating the polynucleotide synthesized in step (b) from the template; d) annealing a nested oligonucleotide to the second end of the polynucleotide synthesized in step (b), the nested oligonucleotide having a first portion that anneals to the second end of the polynucleotide and a second portion having the same predetermined sequence as the second portion of the primer; e) extending the polynucleotide synthesized in step (b) to provide
    Type: Grant
    Filed: September 19, 2002
    Date of Patent: December 11, 2007
    Assignee: Alexion Pharmaceuticals, Inc.
    Inventors: Toshiaki Maruyama, Shana Frederickson, Katherine S. Bowdish, Mark Renshaw, Ying-Chi Lin
  • Rationally designed antibodies
    Publication number: 20040253242
    Abstract: Antibodies or fragments thereof having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the carboxy-terminal and amino-terminal ends of the peptide in covalent association with adjacent framework regions. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities.
    Type: Application
    Filed: December 15, 2003
    Publication date: December 16, 2004
    Inventors: Katherine S. Bowdish, Shana Frederickson, Mark Renshaw, Cecelia Orencia
  • Engineered templates and their use in single primer amplification
    Publication number: 20040175736
    Abstract: Methods of amplifying nucleic acid have now been discovered which include the steps of: a) annealing a primer to a template nucleic acid sequence, the primer having a first portion which anneals to the template and a second portion of predetermined sequence; b) synthesizing a polynucleotide that anneals to and is complementary to the portion of the template between the location at which the first portion of the primer anneals to the template and the end of the template, the polynucleotide having a first end and a second end, wherein the first end incorporates the primer; c) separating the polynucleotide synthesized in step (b) from the template; d) annealing a nested oligonucleotide to the second end of the polynucleotide synthesized in step (b), the nested oligonucleotide having a first portion that anneals to the second end of the polynucleotide and a second portion having the same predetermined sequence as the second portion of the primer; e) extending the polynucleotide synthesized in step (b) to provide
    Type: Application
    Filed: December 15, 2003
    Publication date: September 9, 2004
    Inventors: Toshiaki Maruyama, Katherine S. Bowdish, Shana Frederickson, Mark Renshaw
  • Engineered templates and their use in single primer amplification
    Publication number: 20040072164
    Abstract: Methods of amplifying nucleic acid have now been discovered which include the steps of: a) annealing a primer to a template nucleic acid sequence, the primer having a first portion which anneals to the template and a second portion of predetermined sequence; b) synthesizing a polynucleotide that anneals to and is complementary to the portion of the template between the location at which the first portion of the primer anneals to the template and the end of the template, the polynucleotide having a first end and a second end, wherein the first end incorporates the primer; c) separating the polynucleotide synthesized in step (b) from the template; d) annealing a nested oligonucleotide to the second end of the polynucleotide synthesized in step (b), the nested oligonucleotide having a first portion that anneals to the second end of the polynucleotide and a second portion having the same predetermined sequence as the second portion of the primer; e) extending the polynucleotide synthesized in step (b) to provide
    Type: Application
    Filed: September 19, 2002
    Publication date: April 15, 2004
    Inventors: Toshiaki Maruyama, Shana Frederickson, Katherine S. Bowdish, Mark Renshaw, Ying-Chi Lin
  • Rationally designed antibodies
    Publication number: 20030232972
    Abstract: Antibodies or fragments thereof having at least two CDR regions replaced or fused with biologically active peptides are described. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities.
    Type: Application
    Filed: December 2, 2002
    Publication date: December 18, 2003
    Inventors: Katherine S. Bowdish, Shana Frederickson, Mark Renshaw
  • Engineered plasmids and their use for in situ production of genes
    Publication number: 20030049731
    Abstract: Nucleic acid sequences encoding at least a portion of a polypeptide are directly incorporated into a plasmid by DNA polymerization or reverse transcription of a nucleic acid template. In particularly preferred embodiments, nucleic acid sequences encoding at least a portion of an antibody are directly incorporated into a plasmid by reverse transcription of messenger RNA (mRNA).
    Type: Application
    Filed: December 5, 2001
    Publication date: March 13, 2003
    Inventors: Katherine S. Bowdish, Shana Frederickson, Ying-Chi Lin, Mark Renshaw, Martha Wild, John McWhirter
  • Rationally designed antibodies
    Publication number: 20030049683
    Abstract: Antibodies or fragments thereof having CDR regions replaced or fused with biologically active peptides are described. Flanking sequences may optionally be attached at one or both the carboxy-terminal and amino-terminal ends of the peptide in covalent association with adjacent framework regions. Compositions containing such antibodies or fragments thereof are useful in therapeutic and diagnostic modalities.
    Type: Application
    Filed: December 5, 2001
    Publication date: March 13, 2003
    Inventors: Katherine S. Bowdish, Shana Frederickson, Mark Renshaw