Patents by Inventor Mark Richard Witmer

Mark Richard Witmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7314726
    Abstract: The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.
    Type: Grant
    Filed: October 15, 2003
    Date of Patent: January 1, 2008
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael G. Kornacker, Robert A. Copeland, Joseph Hendrick, Zhihong Lai, Claudio Mapelli, Mark Richard Witmer, Jovita Marcinkeviciene, William Metzler, Ving Lee, Douglas James Riexinger
  • Publication number: 20040121412
    Abstract: The present invention provides peptides that specifically bind to BACE at a newly discovered exosite. The invention also provides methods for identifying peptides that bind to a BACE exosite. The invention further provides methods for identifying compounds that bind to a BACE exosite and modulate BACE activity. In another aspect, the invention provides methods for treating or preventing neurodegenerative disorders such as Alzheimer's disease by administering compounds that bind to a BACE exosite and modulate BACE activity.
    Type: Application
    Filed: October 15, 2003
    Publication date: June 24, 2004
    Inventors: Michael G. Kornacker, Robert A. Copeland, Joseph Hendrick, Zhihong Lai, Claudio Mapelli, Mark Richard Witmer, Jovita Marcinkeviciene, William Metzler, Ving Lee, Douglas James Riexinger