Abstract: Example wire spool hub assemblies include: a spindle configured to hold a wire spool; a spool rotation resistor positioned on the spindle to resist rotation of the wire spool on the spindle; and a resistance adjuster configured to selectively apply two or more rotation resistances via the spool rotation resistor based on two or more discrete positions of the resistance adjuster.

Abstract: The present invention provides new intermediates and processes useful in the manufacture of tirzepatide, or a pharmaceutically acceptable salt thereof.

Abstract: A respiratory mask includes a frame and a cushion module. The frame can include a front wall having a vent and/or a gas inlet opening and a collar extending away from the front wall. The collar surrounds the vent and/or the gas inlet opening. The cushion module comprises a cushion and a housing, which is made of a material more rigid than the cushion. The housing defines a connection opening. A friction coupling selectively couples the cushion module to the frame and comprises an elastomeric friction member coupled to a portion of the housing that defines the connection opening. In some arrangements, an outer surface of the friction member is exposed when the cushion module is coupled to the frame. In some arrangements, the housing extends through the peripheral surface.

Abstract: The present disclosure generally relates to fluid therapy based on patient data, and associated systems, devices, and methods. Embodiments of the present technology include trained models configured to improve the effectiveness of fluid therapy received by a patient. In some embodiments, the models improve a specific patient's response to fluid therapy, and predict whether a patient is expected to respond to fluid therapy, based on data associated with the patient's response to the fluid therapy.

Abstract: Aircraft modification system for transforming an aircraft (that includes an aircraft fuselage, aircraft flight control surfaces, and aircraft subsystems). The aircraft modification system includes an aerial refueling system (ARS), a refueling system(s) manager, interface subsystems (including multi-dimensional/adjustable structural supports and operative interconnection systems) that secure the ARS to a fuselage subsystem and operatively interface the ARS with the aircraft systems, the refueling system(s) manager, and other systems of the aircraft modification system.

Abstract: An emitter outlet defining an ingress channel having a first volume and area, and having a first portion that is substantially perpendicular to a second portion located downstream of the first portion which causes fluid flowing through the ingress channel to make a first fluid velocity reducing turn, and a first opening located off of the second portion that causes at least a portion of the fluid flowing through the ingress channel to make a second fluid velocity reducing turn, and an outlet bath with a second volume and area that is larger than the first volume and area of the ingress channel so as to cause further pressure and/or velocity reduction of the fluid entering into the outlet bath. In addition, emitters, drip lines and various methods relating to such an emitter outlet configuration are also disclosed.

Abstract: This invention relates to compounds of formula (I) and methods of treatment using the compounds. The invention also relates to processes and methods for producing the compounds of the invention. The compounds of the invention are modulators of Factor XII (e.g. Factor XIIa). In particular, the compounds are inhibitors of Factor XIIa and may be useful as anticoagulants.

Abstract: A mask assembly is provided comprising a cushion with a proximal face contacting portion, a distal inlet aperture, and a side wall between the proximal face contacting portion and the distal inlet aperture, a frame; and an inlet connector configured to connect to a source of pressurised gas. The frame comprises upper and lower headgear connectors both of which are below the cushion uppermost portion. The frame comprises a central connection portion removably connected to the cushion and the inlet connector. The central connection portion is relatively inflexible, whilst the remainder of the frame may be relatively flexible. The inlet connector comprises an inlet port for connection to a gas delivery conduit, and comprises a downwardly directed central axis.

Abstract: A technique for performing a path tracing operation is provided. A cache is interrogated using a probe operation that returns a Boolean result for each of a plurality of scene data elements associated with the path tracing operation. The Boolean result indicates presence or absence of a scene data element in the cache. The path tracing operation executes at least a first instruction based at least in part on the probe operation returning a Boolean result indicating absence of one of the scene data elements in the cache. The path tracing operation executes at least a second instruction based at least in part on the probe operation returning a Boolean result indicating presence of said one scene data element in the cache, wherein the first instruction is different from the second instruction.

Abstract: Aircraft performance modification system including one or more processor systems operatively integrated with one or more components of the aircraft.

Abstract: According to at least one embodiment, a method, a computer system, and a computer program product for minimizing I/O operations when validating databases are provided. The present invention may include creating a corresponding system-managed chain database for an application database, the chain database comprising a list of one or more dynamically allocated records, if present, for one or more fixed entries in the application database, wherein each of the fixed entries comprises a respective chain database array item in the chain database; scanning, via a validation utility, one or more chain database array items; marking each of the one or more dynamically allocated records listed in the chain database for the fixed entries as found; and checking, via an indicator with various states, if the one or more dynamically allocated records for the one or more fixed entries are listed in the respective chain database array item.

Abstract: A welding sled, comprising a support base comprising one or more attachment points for attachment of a wire supply support and attachment of a wire drive assembly; a plurality of rollers coupled to a bottom of the support base; and a brake configured to selectively brake the welding sled.

Abstract: An MRI system for imaging a human breast region of a patient comprising a breast coil comprising a housing including a top portion, a bottom portion, a left support portion, and a right support portion wherein the top portion, bottom portion, and left support portion define a left cup opening, and the top portion, bottom portion, and right support portion define a right cup opening; and a receive coil configured to image the breast region of the patient; wherein the bottom portion of the housing comprises: a first side adjacent a spine coil, the first side and the spine coil each being disposed on a tabletop; and a second side overlapping a top surface of the spine coil such that a top surface of the bottom portion is approximately horizontal.

Abstract: An MRI support structure for imaging a breast region of a patient, said support structure comprising: a housing including a top portion, a bottom portion, a left support portion, and a right support portion wherein the top portion, bottom portion, and left support portion define a left cup opening, and the top portion, bottom portion, and right support portion define a right cup opening; a rail system comprising a plurality of rails each coupled to a bottom surface of the top portion; a lateral grid plate holder comprising a ratchet mechanism engaged with the rail system and configured to ratchet along the rail system in a medial direction; and a medial grid plate holder coupled to a top surface of the bottom portion.

Abstract: Systems and methods for ambient electromagnetic power harvesting (AEPH) chip reader-writer devices are provided that selectively control RF parameters of electro-magnetic (EM) signals transmitted to an AEPH chip. In embodiments, the selection of which RF parameter configuration is applied when transmitting an EM signal is determined by an RF parameter selection processor based on the function being invoked from the AEPH chip. In one embodiment, an AEPH chip reader-writer selects a first configuration of radio frequency (RF) parameters from a plurality of RF parameters based on a determination of a first operation for execution by an ambient electromagnetic power harvesting chip; configures an RF transmit path circuit to use the first configuration of RF parameters; and initiates execution of the first operation in the ambient electromagnetic power harvesting chip by transmitting via the RF transmit path circuit a first electromagnetic signal using the first configuration of RF parameters.

Abstract: A method is disclosed for washing an amino acid that has been added to a solid phase resin during solid phase peptide synthesis (SPPS), comprising: adding a first quantity of wash solvent, wherein once the wash with the first quantity of wash solvent is complete, sending the first quantity of wash solvent to waste; and adding a second quantity of wash solvent, wherein once the wash with the second quantity of wash solvent is complete, sending the second quantity of wash solvent to a container, wherein the second quantity of wash solvent will be used in the first wash for the next amino acid that is added.

Abstract: According to at least one embodiment, a method, a computer system, and a computer program product for minimizing I/O operations when validating databases are provided. The present invention may include creating a corresponding system-managed chain database for an application database, the chain database comprising a list of one or more dynamically allocated records, if present, for one or more fixed entries in the application database, wherein each of the fixed entries comprises a respective chain database array item in the chain database; scanning, via a validation utility, one or more chain database array items; marking each of the one or more dynamically allocated records listed in the chain database for the fixed entries as found; and checking, via an indicator with various states, if the one or more dynamically allocated records for the one or more fixed entries are listed in the respective chain database array item.

Abstract: This invention relates to a removable cap which is metallic to facilitate recovery and recycling. The removable metal cap is for a container, such as tin or jar which may contain supplements or foodstuffs. The metallic removable cap has a thread for screwing the metal cap onto a threaded opening of a container. A retaining bead is provided on its inner surface and retains a two-piece wad. The two-piece wad is formed from an upper (cap) layer and a lower (container) layer. When installed the lower layer seals the container and the retaining bead retains the two-piece wad until removal of the metal cap from the container whereupon the upper layer of the wad separates from the lower layer of the wad and is held inside the metal cap by the retaining bead.

Abstract: Example apparatus disclosed herein are to obtain, from a network monitor, an address associated with one or more network communications used to convey a media stream to a first input device of a plurality of input devices in communication with a media device, query one or more data structures based on the address to identify a first input source of the media device, the one or more data structures to map respective ones of the plurality of input devices to corresponding ones of a plurality of input sources of the media device, the plurality of input sources including the first input source, obtain a watermark from a meter that is to monitor an output of the media device, and identify the first input source of the media device as associated with media presented by the media device in response to determination that the watermark corresponds to the media stream.

Abstract: Various implementations include in-ear wearable audio devices. In certain implementations, the in-ear audio devices include an eartip with a body having first and second ends, an inner wall extending between the first and second ends defining a hollow passage to conduct acoustic energy, and a deformable outer wall connected to the inner wall of the body at the first end and tapering away from the inner wall toward the second end, where the deformable outer wall is functionally graded from the first end to the second end to comply with an entrance of an ear canal of a user. In additional implementations, the eartip includes a retaining structure, and at least one of the inner wall or the outer wall of the body, or the retaining structure, has an integral electronic component and/or an electronic component signal trace.