Patents by Inventor Mark Ridgill

Mark Ridgill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bicyclic inhibitors of PAD4
    Patent number: 9963448
    Abstract: The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: May 8, 2018
    Assignee: Padlock Therapeutics, Inc.
    Inventors: Rajesh Devraj, Gnanasambandam Kumaravel, Michael F. Parker, Edward Beaumont, Lee Bowles, Steve Bromidge, Sophie Cooper, Elise Gadouleau, Laura Gleave, Philip Kerry, Adrian Kotey, Thomas Krulle, Cristina Lecci, Pui Loke, Mirco Meniconi, Nat Monck, Carl North, Jordan Palfrey, Shelley Parrott, Mark Ridgill, Heather Tye
  • BICYCLIC INHIBITORS OF PAD4
    Publication number: 20170166565
    Abstract: The present invention provides compounds useful as inhibitors of PAD4, compositions thereof, and methods of treating PAD4-related disorders.
    Type: Application
    Filed: December 9, 2016
    Publication date: June 15, 2017
    Inventors: Rajesh Devraj, Gnanasambandam Kumaravel, Michael F. Parker, Edward Beaumont, Lee Bowles, Steve Bromidge, Sophie Cooper, Elise Gadouleau, Laura Gleave, Philip Kerry, Adrian Kotey, Thomas Krulle, Cristina Lecci, Pui Loke, Mirco Meniconi, Nat Monck, Carl North, Jordan Palfrey, Shelley Parrott, Mark Ridgill, Heather Tye
  • Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
    Publication number: 20080070895
    Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: September 7, 2007
    Publication date: March 20, 2008
    Inventors: Ian Collins, Laura Cooper, Timothy Harrison, Linda Keown, Andrew Madin, Mark Ridgill
  • Piperidines and Related Compounds for Treatment of Alzheimer's Disease
    Publication number: 20080021043
    Abstract: Compounds of formula I: selectively inhibit production of A?(1-42) and hence are useful in treatment or prevention of disease associated with deposition of ?-amyloid in the brain.
    Type: Application
    Filed: October 20, 2005
    Publication date: January 24, 2008
    Applicant: MERCK SHARP & DOHME LTD.
    Inventors: Joanne Hannam, Janusz Kulagowski, Andrew Madin, Mark Ridgill, Eileen Seward
  • Gamma-secretase inhibitors
    Publication number: 20060293373
    Abstract: Compounds of formula I: are potent inhibitors of gamma-secretase and hence find use in treatment or prevention of diseases associated with deposition of ?-amyloid.
    Type: Application
    Filed: September 16, 2004
    Publication date: December 28, 2006
    Applicant: MERCK SHARP & DOHME LIMITED
    Inventors: Ian Collins, Joanne Hannam, Andrew Madin, Mark Ridgill
  • Heteroaryl substituted spirocyclic sulfamides for inhibition of gamma secretase
    Publication number: 20060173054
    Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: March 2, 2006
    Publication date: August 3, 2006
    Inventors: Ian Collins, Laura Cooper, Timothy Harrison, Linda Keown, Andrew Madin, Mark Ridgill
  • Cyclic sulfamides for inhibiton of gamma-secretase
    Publication number: 20060135570
    Abstract: Compounds of formula I: inhibit the processing of AP by gamma-secretase, and hence are useful for treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: October 31, 2003
    Publication date: June 22, 2006
    Inventors: Ian Collins, Joanne Hannam, Timothy Harrison, Andrew Madin, Mark Ridgill
  • Alkynly-substituted spirocyclic sulfamides for the treatment of alzheimer's disease
    Publication number: 20050215602
    Abstract: Compounds of formula (I) are disclosed. The compounds inhibit gamma-secretase and hence find use in treatment of Alzheimer's disease.
    Type: Application
    Filed: April 24, 2003
    Publication date: September 29, 2005
    Inventors: Alister Campbell, Mark Ridgill
  • Alkenyl-substituted spirocyclic sulfamides as inhibitors of gamma-secretase
    Publication number: 20050182111
    Abstract: Compounds of formula (I) are disclosed: wherein R4 is an alkenyl group of defined structure. The compounds inhibit gamma-secretase, and hence are useful for treatment of Alzheimer's disease.
    Type: Application
    Filed: April 24, 2003
    Publication date: August 18, 2005
    Inventors: Jose Pineiro, Joanne Hannam, Timothy Harrison, Andrew Madin, Mark Ridgill
  • Heteroaryl substituted spriocyclic sulfamides for inhibition of gamma secretase
    Publication number: 20050182109
    Abstract: Compounds of formula I are disclosed: in which X is a 5-membered heteroaryl ring and R is as defined herein. The compounds are inhibitors of the processing of APP by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.
    Type: Application
    Filed: April 24, 2003
    Publication date: August 18, 2005
    Inventors: Ian Collins, Laura Cooper, Timothy Harrison, Linda Keown, Andrew Madin, Mark Ridgill