Abstract: A non-invasive diagnostic system assesses the optimal timing for aortic valve replacement (AVR) by quantifying left-ventricular Frank-Starling reserve before irreversible myocardial damage occurs. The system (i) acquires left-ventricular ejection time (LVET) and other systolic-time intervals from optical or vibrational sensors positioned on the patient, (ii) induces a reversible preload change—e.g., passive leg raise or posture transition—to create a controlled venous-return increment, (iii) processes the paired baseline and post-maneuver waveforms to extract systolic time interval metrics, and (iv) analyzes the ?LVET/?preload relationship against historical or population references. A diminished LVET response signals loss of contractile reserve, enabling timely AVR while myocardial changes remain reversible. The platform integrates measurement hardware, a data-processing engine, a data-analysis module, and a reporting interface, and may be configured as a wrist, ring, chest, or ear sensor.

Abstract: An assessment of basal cardiac fitness uses noninvasively obtained physiological measures to determine the presence of a basal physiological state and cardiometric measures to determine cardiac fitness. In the presence of preload independence and cardiac vagal control, cardiometric signals are acquired that are sensitive to cardiac function and include information indicative of the opening and closing of the individual's aortic valve. The cardiometric signals are analyzed by a cardiac fitness assessment system for the determination of basal cardiac fitness. The invention assures preload independence through the assessment of observational physiological parameters or the use of physiological parameters obtained following alterations in venous return. The invention assures the presence of cardiac vagal control by assessment of measured parameters, including the presence of respiratory sinus arrhythmia.

Abstract: The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

Abstract: The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

Abstract: Embodiments of the present invention address the limitations of current central venous pressure monitoring by providing a noninvasive, non-implanted, and self-administered test for the determination of central venous pressure. Some embodiments use alterations in transmural pressure, optical measurements of venous volume, and anatomical measurements to determine central venous pressure. The system can provide an absolute measurement of central pressure and can be used to monitor relative changes in central venous pressure over time. Changes in transmural pressure are used to create detectable changes in peripheral venous vascular volume for central venous pressure measurement.

Abstract: The systems and methods described herein provide hands free motor control mechanisms based on the natural and inherent movements associated with an activity of interest, and can be combined with gestures or verbal communication based upon pre-defined movements by the participant.

Abstract: Method and systems are provided for reliable, convenient, self-administered, and cost-effective determination of central venous pressure. The noninvasive method and apparatus use changes in transmural pressure to create detectable changes in peripheral venous vascular volume for the determination of central venous pressure. Transmural pressure changes can be manifested by intravascular or extravascular pressure changes. The system is noninvasive and uses optical measurements of venous volume in the presence of transmural pressure changes. The relationship between the transmural pressure change and the change in vascular venous volume is combined with anatomical measurements to determine the central venous pressure of the subject. Central venous pressure can be used to determine hemodynamic status of the subject to include fluid overload in the heart failure patient.

Abstract: Embodiments provide a reliable, convenient, noninvasive, and cost-effective determination of structural and valvular abnormalities in the left ventricular outflow tract. Embodiments obtain a noninvasive optical pulse plethysmogram from the systolic and diastolic phases of the cardiac cycle for subsequent morphologic waveform analysis to determine left ventricular outflow tract anomalies. Left ventricular outflow tract abnormalities alter the rate of increase in flow during early systole and decrease in flow during late systole. These flow variances at the aortic valve are amplified as the pulse wave moves to the periphery due to a combination of the ventricular-aortic interaction, pulse augmentation, and reflections at branching vessels and changes in diameter.

Abstract: The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

Abstract: The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

Abstract: The systems and methods described herein provide hands free motor control mechanisms based on the natural and inherent movements associated with an activity of interest, and can be combined with gestures or verbal communication based upon pre-defined movements by the participant.

Abstract: Embodiments of the present invention provide reliable, convenient, and cost-effective methods and apparatuses to determine the hemodynamic status of the patent. The methods and apparatuses provide for the noninvasive determine of hemodynamic status by using systematic perturbations of venous return or trend observation over time. Embodiments do not require invasive pressure monitoring or the use of ventilator but instead can be an entirely noninvasive system.

Abstract: The systems and methods described herein provide hands free motor control mechanisms based on the natural and inherent movements associated with an activity of interest, and can be combined with gestures or verbal communication based upon pre-defined movements by the participant.

Abstract: The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

Abstract: The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

Abstract: Method and systems provide for reliable, convenient, and cost-effective personalized assessment of hemodynamic status in the ambulatory heart failure patient. The method and apparatus use pulse contour analysis of data obtained through observation of the patient for determination of hemodynamic status, and for determination of day-to-day changes in hemodynamic status. Observational assessment of the patient includes monitoring during activities of daily living including sleeping, sitting and standing. These activities create changes in venous return that are used to evaluate cardiac function or changes in cardiac function. The method and system infer body position by using position and motion information obtained by the system. Changes in cardiac function over time or due to changes in body pose are evaluated for the assessment of hemodynamic status, with a focus on changes resulting from fluid overload.

Abstract: Embodiments of the present invention provide reliable, convenient, and cost-effective methods and apparatuses to determine the hemodynamic status of the patent. The methods and apparatuses provide for the noninvasive determine of hemodynamic status by using systematic perturbations of venous return or trend observation over time. Embodiments do not require invasive pressure monitoring or the use of ventilator but instead can be an entirely noninvasive system.

Abstract: Method and systems provide for reliable, convenient, and cost-effective personalized assessment of hemodynamic status in the ambulatory heart failure patient. The method and apparatus use pulse contour analysis of data obtained through observation of the patient for determination of hemodynamic status, and for determination of day-to-day changes in hemodynamic status. Observational assessment of the patient includes monitoring during activities of daily living including sleeping, sitting and standing. These activities create changes in venous return that are used to evaluate cardiac function or changes in cardiac function. The method and system infer body position by using position and motion information obtained by the system. Changes in cardiac function over time or due to changes in body pose are evaluated for the assessment of hemodynamic status, with a focus on changes resulting from fluid overload.

Abstract: The present invention provides methods and systems that provide for reliable, convenient, and noninvasive assessment of hydration status. The methods and apparatuses can use the temporal sequence of the aortic value opening and closing along with the user's body position to derive parameters that determine the hydration status of the user. The user can use this information to make near-term lifestyle changes that can improve physical performance, health, and general wellbeing.

Abstract: Method and systems are provided for reliable, convenient, self-administered, and cost-effective determination of central venous pressure. The noninvasive method and apparatus use changes in transmural pressure to create detectable changes in peripheral venous vascular volume for the determination of central venous pressure. Transmural pressure changes can be manifested by intravascular or extravascular pressure changes. The system is noninvasive and uses optical measurements of venous volume in the presence of transmural pressure changes. The relationship between the transmural pressure change and the change in vascular venous volume is combined with anatomical measurements to determine the central venous pressure of the subject. Central venous pressure can be used to determine hemodynamic status of the subject to include fluid overload in the heart failure patient.