Patents by Inventor Mark Robert Pearce-Higgins

Mark Robert Pearce-Higgins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220289832
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Application
    Filed: May 23, 2022
    Publication date: September 15, 2022
    Inventors: MARIANGELA SPITALI, JONATHAN SYMMONS, RICHARD WHITCOMBE, MARK ROBERT PEARCE-HIGGINS
  • Patent number: 11384136
    Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.
    Type: Grant
    Filed: November 5, 2019
    Date of Patent: July 12, 2022
    Assignee: UCB BIOPHARMA SRL
    Inventors: Jean-Pascal Pierre Bilgischer, Philip Jonathan Bassett, Mark Robert Pearce-Higgins, Andrew John Kenny
  • Patent number: 11339214
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Grant
    Filed: January 16, 2019
    Date of Patent: May 24, 2022
    Assignee: UCB PHARMA, S.A.
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • Publication number: 20200071387
    Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.
    Type: Application
    Filed: November 5, 2019
    Publication date: March 5, 2020
    Inventors: JEAN-PASCAL PIERRE BILGISCHER, PHILIP JONATHAN BASSETT, MARK ROBERT PEARCE-HIGGINS, ANDREW JOHN KENNY
  • Patent number: 10487136
    Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.
    Type: Grant
    Filed: February 2, 2011
    Date of Patent: November 26, 2019
    Assignee: UCB BIOPHARMA SPRL
    Inventors: Jean-Pascal Pierre Bilgischer, Philip Jonathan Bassett, Mark Robert Pearce-Higgins, Andrew John Kenny
  • Publication number: 20190135909
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Application
    Filed: January 16, 2019
    Publication date: May 9, 2019
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • Patent number: 10189897
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: January 29, 2019
    Assignee: UCB PHARMA, S.A.
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • Publication number: 20160108119
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Application
    Filed: December 22, 2015
    Publication date: April 21, 2016
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • Patent number: 9309280
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Grant
    Filed: July 26, 2011
    Date of Patent: April 12, 2016
    Assignee: UCB PHARMA, S.A.
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • Publication number: 20130184439
    Abstract: The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.
    Type: Application
    Filed: July 26, 2011
    Publication date: July 18, 2013
    Applicant: UCB PHARMA, S.A.
    Inventors: Mariangela Spitali, Jonathan Symmons, Richard Whitcombe, Mark Robert Pearce-Higgins
  • Publication number: 20130060009
    Abstract: The present disclosure relates to a method for the manufacture of recombinant antibody molecules comprising culturing a host cell sample transformed with an expression vector encoding a recombinant antibody molecule; adding an extraction buffer to the sample; and subjecting the sample to a heat treatment step; wherein the pH of the sample is detected after addition of the extraction buffer, and optionally adjusted, to ensure that the pH of the sample is 6 to 9 prior to the heat treatment step.
    Type: Application
    Filed: February 2, 2011
    Publication date: March 7, 2013
    Inventors: Jean-Pascal Pierre Bilgischer, Philip Jonathan Bassett, Mark Robert Pearce-Higgins, Andrew John Kenny