Abstract: Provided herein are anaplastic lymphoma kinase (ALK) fusion nucleic acid molecules and polypeptides, methods related to detecting ALK fusion nucleic acid molecules and polypeptides in cancer, as well as methods of treatment and uses related thereto. Detection of an ALK fusion nucleic acid molecule or polypeptide can be used to identify individuals that may benefit from treatment with an anti-cancer therapy.

Abstract: The present disclosure provides COL5A2-ALK fusion nucleic acid molecules and polypeptides, and COL3A1-ALK fusion nucleic acid molecules and polypeptides, as well as methods, kits and reagents for detecting such fusion nucleic acid molecules and polypeptides. The disclosure also provides methods for evaluating, identifying, assessing, and/or treating an individual having a cancer.

Abstract: Provided herein are methods related to detecting overexpression of an oncogene through translocations in the immunoglobulin heavy (IGH) locus, as well as methods of treatment, uses, and kits related thereto. As demonstrated herein, IGH translocations lead to oncogene overexpression when the distance from a breakpoint of the translocation to the transcription start site (TSS) of an oncogene is within 0-1.3 Mb. As such, detecting IGH translocations in which a breakpoint is 1.3 Mb or less from an oncogene TSS may find use, e.g., in detecting oncogene overexpression, providing assessment/diagnosis, identifying individuals for treatment, selecting therapies, identifying treatment options, and treating or delaying progression of cancer, e.g., using relevant targeted and/or non-targeted therapies.

Abstract: A method of cleaning a component within a turbine that includes disassembling the turbine engine to provide a flow path to an interior passageway of the component from an access point. The component has coked hydrocarbons formed thereon. The method further includes discharging a flow of cleaning solution towards the interior passageway from the access point, wherein the cleaning solution is configured to remove the coked hydrocarbons from the component.

Abstract: A method of cleaning a component within a turbine that includes disassembling the turbine engine to provide a flow path to an interior passageway of the component from an access point. The component has coked hydrocarbons formed thereon. The method further includes discharging a flow of cleaning solution towards the interior passageway from the access point, wherein the cleaning solution is configured to remove the coked hydrocarbons from the component.

Abstract: NTRK fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing, and/or treating a subject having a cancer are disclosed.

Abstract: A gas turbine engine includes a liner positioned within a compressor section or a turbine section of the gas turbine engine and at least partially defining a core air flowpath through the gas turbine engine. The gas turbine engine also includes a casing at least partially enclosing the liner. Additionally, the gas turbine engine includes a pressure sensor assembly having a body, an extension member, and a pressure sensor. The pressure sensor is positioned at least partially within the body and the body is positioned at least partially on an outer side of the casing, the extension member extending from the body through a casing opening in the casing and towards a liner opening in the liner. The extension member defines a continuous sense cavity exposing the pressure sensor to the core air flowpath.

Abstract: A method of cleaning a component within a turbine that includes disassembling the turbine engine to provide a flow path to an interior passageway of the component from an access point. The component has coked hydrocarbons formed thereon. The method further includes discharging a flow of cleaning solution towards the interior passageway from the access point, wherein the cleaning solution is configured to remove the coked hydrocarbons from the component.

Abstract: A method of cleaning a component within a turbine that includes disassembling the turbine engine to provide a flow path to an interior passageway of the component from an access point. The component has coked hydrocarbons formed thereon. The method further includes discharging a flow of cleaning solution towards the interior passageway from the access point, wherein the cleaning solution is configured to remove the coked hydrocarbons from the component.

Abstract: A gas turbine engine includes a liner positioned within a compressor section or a turbine section of the gas turbine engine and at least partially defining a core air flowpath through the gas turbine engine. The gas turbine engine also includes a casing at least partially enclosing the liner. Additionally, the gas turbine engine includes a pressure sensor assembly having a body, an extension member, and a pressure sensor. The pressure sensor is positioned at least partially within the body and the body is positioned at least partially on an outer side of the casing, the extension member extending from the body through a casing opening in the casing and towards a liner opening in the liner. The extension member defines a continuous sense cavity exposing the pressure sensor to the core air flowpath.

Abstract: A multi-functional food processing system includes a base having a first drive coupler and a second drive coupler, a first container to engage the first drive coupler, a second container to engage the second drive coupler, and a third container to engage the first drive coupler or the second drive coupler. The first container includes a first processing assembly where the first drive coupler is operable to rotate the first processing assembly at a first speed while the second container includes a second processing assembly where the second drive coupler is operable to rotate the second processing assembly at a second speed. The third container includes a third processing assembly and a transmission system, where the first drive coupler or the second drive coupler is operable to drive the transmission system to rotate the third processing assembly at a third speed.

Abstract: The present disclosure is directed to a method for rejuvenating a damaged coated component of a gas turbine engine. The method includes uninstalling the damaged coated component from the gas turbine engine. The method also includes isolating a first coated portion of the component of the gas turbine engine from a second coated portion of the component. In addition, the method includes simultaneously depositing a first coating material on the first coated portion of the component and a different, second coating material on the second coated portion of the component. The method also includes reinstalling the rejuvenated coated component into the gas turbine engine.

Abstract: A steam frame for a steam appliance has a body, a passageway in the body for passage of a fluid medium, and a member such as an unbalanced rotatable turbine in fluid communication with the passageway, where the member is capable of being engaged by the fluid medium to produce vibrations in the body for enhanced cleaning performance. A steam attachment includes a body, a pad covering at least a portion of the body, and a heating element coupled to the body. The heating element is configured to increase the temperature of the pad for enhanced cleaning performance. The heating element and vibration-producing member may be used separately or together.

Abstract: A slurry coating composition for enriching a surface region of a metal-based substrate with chromium includes a metallic powder including chromium powder in the Cr(0) oxidation state and aluminum powder; a binder including colloidal silica to bind the metallic powder; and a stabilizer, wherein the chromium powder comprises at least about 80% by weight of the metallic powder and the aluminum powder comprises up to about 10% by weight of the metallic powder. A process of forming a coating and enriching a surface region of a component formed of a nickel-based superalloy with chromium includes applying the slurry coating composition to the surface region of the component to form a slurry coating on the surface region; curing the slurry coating to form a green coating; and sintering the green coating to form a coating having chromium in the alpha phase at an operating temperature of the component between about 1200° C. to about 1800° C.

Abstract: Food processing assemblies for rotating two processing tools inside a container at two different speeds and/or directions and methods for using such a processing assembly are disclosed. The two processing tools are vertically spaced along the longitudinal axis of the processing assembly. A motor drives the first processing tool and a transmission system, and the transmission system drives the second processing tool. The transmission system outputs a rotation speed and/or direction is different from that of the motor to drive the second processing tool. The transmission system may be located between the two processing tools within the food-containing volume of the container.

Abstract: A food processor includes at least two different types of blades to process foods. A processing assembly includes a shaft, a set of pureeing blades attached to the shaft, and a set of substantially horizontal blades attached to the shaft. Each substantially horizontal blade may have a rearwardly curved leading cutting edge. The substantially horizontal blades are positioned higher with a food processing container than the pureeing blades. In some embodiments, upwardly angled blades may be included to induce vertical circulation and/or vorticial flow of the processed food.

Abstract: A steam frame for a steam appliance has a body, a passageway in the body for passage of a fluid medium, and a member such as an unbalanced rotatable turbine in fluid communication with the passageway, where the member is capable of being engaged by the fluid medium to produce vibrations in the body for enhanced cleaning performance. A steam attachment includes a body, a pad covering at least a portion of the body, and a heating element coupled to the body. The heating element is configured to increase the temperature of the pad for enhanced cleaning performance. The heating element and vibration-producing member may be used separately or together.

Abstract: Appliances, methods and systems in which steam can be applied to a fabric and a heated surface can be used to press and/or dry the fabric.

Abstract: Steam applicators, steam applicator frames, and steam appliance systems in which a steam applicator can be maneuvered to clean and sanitize all kinds of surfaces, not merely floors.

Abstract: A multi-functional food processing system includes a base having a first drive coupler and a second drive coupler, a first container to engage the first drive coupler, a second container to engage the second drive coupler, and a third container to engage the first drive coupler or the second drive coupler. The first container includes a first processing assembly where the first drive coupler is operable to rotate the first processing assembly at a first speed while the second container includes a second processing assembly where the second drive coupler is operable to rotate the second processing assembly at a second speed. The third container includes a third processing assembly and a transmission system, where the first drive coupler or the second drive coupler is operable to drive the transmission system to rotate the third processing assembly at a third speed.