Abstract: Systems, methods, and computer-readable media for providing cross device messaging and enhanced synchronization of messages. In some configurations, a distributed service platform may store a user profile. The user profile may include device information (i) indicating active devices associated with the user profile and capabilities of the active devices and (ii) one or more potential relay devices for relaying messages to the active devices. The user profile may be provided to a first device among the active devices referenced in the device information. A signal may be received from the first device that includes a message designating one or more recipient devices from the active devices. One or more relay devices may be selected from the one or more potential relay devices in response to receiving the signal, and the signal may be sent to the one or more relay devices.

Abstract: Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2 and/or IL-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e.g., for enhanced adoptive cell transfer therapies.

Abstract: The present disclosure relates, in general, to human antibodies against human interleukin 2 (IL-2) and methods of use of such antibodies for modulating IL-2 activity and use in the treatment of conditions such as cancer, autoimmune disease, or infection.

Abstract: Representative embodiments disclose intelligent help systems that monitor user interactions through email, digital assistants, and other applications and recognize when a user can utilize the help of an expert with a task. The system detects user intent and a category of problem from the interactions (i.e., email communications, etc.) and searches a database of user profiles to find experts with the proper expertise to help the user with the category of problem. User intent can be detected by parsing communications, extracting features from the communications, and using the extracted features to identify intent, such as through matching or machine learning. A social score and an expertise score are calculated for expert profiles from the database. The social score is based on a degree of separation and expert and the expertise score is based on a level of expertise. Experts and areas of commonality are presented to the user.

Abstract: The present disclosure relates, in general, to human antibodies against human interleukin 2 (IL-2) and methods of use of such antibodies for modulating IL-2 activity and use in the treatment of conditions such as cancer, autoimmune disease, or infection.

Abstract: An electronic communication device and method for communication including automatically selecting, composing, and/or presenting a number of proposed responses to a message is disclosed. The device can present the incoming message content to the user together with an alert to the user that one or more proposed responses are available for review and selection. The device can calculate a confidence metric for each proposed response. The user alert and/or presentation of the messages can be made to vary in intensity in accordance with the confidence metric of the one or more proposed responses. The presentation of the proposed responses can be alternated and/or combined with a method for the device to receive user input to the content of the proposed response. The user can edit a proposed response rather than composing a complete response.

Abstract: Systems, methods, and computer-readable media for providing cross device messaging and enhanced synchronization of messages. In some configurations, a distributed service platform may store a user profile. The user profile may include device information (i) indicating active devices associated with the user profile and capabilities of the active devices and (ii) one or more potential relay devices for relaying messages to the active devices. The user profile may be provided to a first device among the active devices referenced in the device information. A signal may be received from the first device that includes a message designating one or more recipient devices from the active devices. One or more relay devices may be selected from the one or more potential relay devices in response to receiving the signal, and the signal may be sent to the one or more relay devices.

Abstract: Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2 and/or IL-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e.g., for enhanced adoptive cell transfer therapies.

Abstract: Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2 and/or IL-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e.g., for enhanced adoptive cell transfer therapies.

Abstract: Systems, methods, and computer-readable media for providing cross device messaging and enhanced synchronization of messages. In some configurations, an endpoint computing device can receive input of a mobile operator message. The endpoint computing device can process the message, and send a signal with the message to a relay computing device for delivery to a recipient computing device. In some configurations, the signal with the message may be sent to the relay device via a reference user profile in a distributed service platform (e.g., the Cloud). The endpoint computing device can send the signal with the message to a single relay computing device, or to multiple relay computing devices, for delivery. In some configurations, the endpoint computing device can send the signal with the message to a first relay device, which can then send the signal with the message to a second relay device for delivery to a recipient device.

Abstract: An electronic communication device and method for communication including automatically selecting, composing, and/or presenting a number of proposed responses to a message is disclosed. The device can present the incoming message content to the user together with an alert to the user that one or more proposed responses are available for review and selection. The device can calculate a confidence metric for each proposed response. The user alert and/or presentation of the messages can be made to vary in intensity in accordance with the confidence metric of the one or more proposed responses. The presentation of the proposed responses can be alternated and/or combined with a method for the device to receive user input to the content of the proposed response. The user can edit a proposed response rather than composing a complete response.

Abstract: An electronic communication device and method for communication including automatically selecting, composing, and/or presenting a number of proposed responses to a message is disclosed. The device can present the incoming message content to the user together with an alert to the user that one or more proposed responses are available for review and selection. The device can calculate a confidence metric for each proposed response. The user alert and/or presentation of the messages can be made to vary in intensity in accordance with the confidence metric of the one or more proposed responses. The presentation of the proposed responses can be alternated and/or combined with a method for the device to receive user input to the content of the proposed response. The user can edit a proposed response rather than composing a complete response.

Abstract: Representative embodiments disclose intelligent help systems that monitor user interactions through email, digital assistants, and other applications and recognize when a user can utilize the help of an expert with a task. The system detects user intent and a category of problem from the interactions (i.e., email communications, etc.) and searches a database of user profiles to find experts with the proper expertise to help the user with the category of problem. User intent can be detected by parsing communications, extracting features from the communications, and using the extracted features to identify intent, such as through matching or machine learning. A social score and an expertise score are calculated for expert profiles from the database. The social score is based on a degree of separation and expert and the expertise score is based on a level of expertise. Experts and areas of commonality are presented to the user.

Abstract: A mobile device may create a message rule to establish a causal relationship between a messaging activity and a device activity or vice versa. A message rule user interface displayed on the mobile device may receive from a user a message parameter, describing at least one of a message format and a message content of a hypothetical received mobile message. The message rule user interface also may receive a response action directive describing a device action to be performed by the mobile device in response to receiving an incoming mobile message corresponding to the message parameter. The mobile device may store a message target rule associating the message parameter with the response action directive. The mobile device may receive the incoming mobile message corresponding to the message parameter and execute the device action according to the response action directive.

Abstract: The present disclosure relates, in general, to human antibodies against human interleukin 2 (IL-2) and methods of use of such antibodies for modulating IL-2 activity and use in the treatment of conditions such as cancer, autoimmune disease, or infection.

Abstract: Cells, such a T-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise IL-2 and/or IL-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e.g., for enhanced adoptive cell transfer therapies.

Abstract: In one example, a mobile message device may create a message rule to establish a causal relationship between a messaging activity and a device activity or vice versa. A mobile message device may present a message rule user interface to the user to establish a message rule. The message rule user interface may receive from the user a message parameter describing at least one of a message format and a message content of a hypothetical mobile message received in a mobile messaging module. The message rule user interface may receive a response action directive describing a device action to be performed by the mobile message device in response to receiving an incoming mobile message matching the message parameter. The mobile message device may store a message target rule associating the message parameter with the response action directive. The mobile message device may receive the incoming mobile message matching the message parameter.

Abstract: An electronic communication device and method for communication including automatically selecting, composing, and/or presenting a number of proposed responses to a message is disclosed. The device can present the incoming message content to the user together with an alert to the user that one or more proposed responses are available for review and selection. The device can calculate a confidence metric for each proposed response. The user alert and/or presentation of the messages can be made to vary in intensity in accordance with the confidence metric of the one or more proposed responses. The presentation of the proposed responses can be alternated and/or combined with a method for the device to receive user input to the content of the proposed response. The user can edit a proposed response rather than composing a complete response.

Abstract: Systems, methods, and computer-readable media for providing cross device messaging and enhanced synchronization of messages. In some configurations, an endpoint computing device can receive input of a mobile operator message. The endpoint computing device can process the message, and send a signal with the message to a relay computing device for delivery to a recipient computing device. In some configurations, the signal with the message may be sent to the relay device via a reference user profile in a distributed service platform (e.g., the Cloud). The endpoint computing device can send the signal with the message to a single relay computing device, or to multiple relay computing devices, for delivery. In some configurations, the endpoint computing device can send the signal with the message to a first relay device, which can then send the signal with the message to a second relay device for delivery to a recipient device.

Abstract: An electronic communication device and method for communication including automatically selecting, composing, and/or presenting a number of proposed responses to a message is disclosed. The device can present the incoming message content to the user together with an alert to the user that one or more proposed responses are available for review and selection. The device can calculate a confidence metric for each proposed response. The user alert and/or presentation of the messages can be made to vary in intensity in accordance with the confidence metric of the one or more proposed responses. The presentation of the proposed responses can be alternated and/or combined with a method for the device to receive user input to the content of the proposed response. The user can edit a proposed response rather than composing a complete response.