Patents by Inventor Mark S. Blumenkranz
Mark S. Blumenkranz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11701221Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.Type: GrantFiled: August 4, 2020Date of Patent: July 18, 2023Assignee: AMO Development, LLCInventors: William Culbertson, Mark S. Blumenkranz, David Angeley, George R. Marcellino, Michael W. Wiltberger, Dan Andersen
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Publication number: 20220304854Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.Type: ApplicationFiled: June 13, 2022Publication date: September 29, 2022Inventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
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Patent number: 11364147Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.Type: GrantFiled: November 16, 2018Date of Patent: June 21, 2022Assignee: AMO Development, LLCInventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
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Publication number: 20220160542Abstract: Aspects of the invention include a device for fluid delivery to the ocular surface having a self-alignment system. The fluid delivery device includes a fluid package having a reservoir and one or more apertures, an actuator component configured to eject fluid from the reservoir through the one or more apertures and an image-based self-alignment system configured to align fluid ejected through the one or more apertures with a target location on the eye of a user. Also provided are methods of using the devices in fluid delivery applications, as well as a kit that includes components of the devices.Type: ApplicationFiled: February 11, 2022Publication date: May 26, 2022Inventors: Daniel V. Palanker, Yehuda Ivri, Mark S. Blumenkranz, Reynaldo Quintana
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Publication number: 20220054308Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.Type: ApplicationFiled: November 5, 2021Publication date: February 24, 2022Inventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
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Publication number: 20210128350Abstract: Fluid delivery devices and methods are described, where the device may comprise a piezoelectric actuator operatively coupled to an ampoule with fluid, under a preloading force. The ampoule may comprise a thin-walled thermoplastic package which includes one or more apertures positioned on the wall of the ampoule. The piezoelectric actuator may be configured to clamp at least partially around the circumference of the ampoule and apply oscillations to its wall. The oscillations, typically in ultrasonic frequency, produce cycles of acoustic pressure in the fluid, leading to ejection of the fluid droplets or streams from the apertures.Type: ApplicationFiled: January 12, 2021Publication date: May 6, 2021Inventors: Yehuda Ivri, Mark S. Blumenkranz, Daniel V. Palanker
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Patent number: 10874553Abstract: System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.Type: GrantFiled: June 1, 2017Date of Patent: December 29, 2020Assignee: AMO Development, LLCInventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
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Publication number: 20200360131Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.Type: ApplicationFiled: August 4, 2020Publication date: November 19, 2020Inventors: William Culbertson, Mark S. Blumenkranz, David Angeley, George R. Marcellino, Michael W. Wiltberger, Dan Andersen
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Patent number: 10736733Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.Type: GrantFiled: May 22, 2017Date of Patent: August 11, 2020Assignee: AMO Development, LLCInventors: William Culbertson, Mark S. Blumenkranz, David Angeley, George R. Marcellino, Michael W. Wiltberger, Dan Anderson
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Publication number: 20190083305Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.Type: ApplicationFiled: November 16, 2018Publication date: March 21, 2019Inventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
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Publication number: 20180369334Abstract: Provided herein are VEGF variant polypeptides and Fc-VEGF variant polypeptide fusions, comprising a first VEGF monomer joined to a second VEGF monomer by a peptide linker or a disulfide bridge. In some embodiments, the VEGF variant polypeptides comprise the formula: A-L-B, wherein A is a first VEGF monomer subunit; B is a second VEGF monomer subunit; and L is a peptide linker having 14 to 20 amino acids. In certain embodiments, disclosed herein, are methods of treating an angiogenic disorder in an individual in need thereof, comprising administering to the individual a VEGF variant polypeptide or an Fc-VEGF variant polypeptide fusion. In certain embodiments, disclosed herein, are kits comprising a VEGF variant polypeptide or Fc-VEGF variant polypeptides.Type: ApplicationFiled: January 15, 2016Publication date: December 27, 2018Applicant: The Board of Trustees of the Leland Stanford Junior UniversityInventors: Jennifer R. Cochran, Shiven Kapur, Mark S. Blumenkranz
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Patent number: 10130510Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.Type: GrantFiled: January 26, 2016Date of Patent: November 20, 2018Assignee: Optimedica CorporationInventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
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Publication number: 20180111972Abstract: Polypeptides comprising hybrid VEGF and PDGF sequences are provided. The polypeptides are useful in inhibition of angiogenesis and treatment of diseases characterized by pathologic neovascularization.Type: ApplicationFiled: January 15, 2016Publication date: April 26, 2018Inventors: Jennifer R. Cochran, Cheuk Lun Leung, Shiven Kapur, Mark S. Blumenkranz
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Publication number: 20170266042Abstract: System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.Type: ApplicationFiled: June 1, 2017Publication date: September 21, 2017Inventors: DANIEL V. PALANKER, MARK S. BLUMENKRANZ, DAVID H. MORDAUNT, DAN E. ANDERSEN
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Publication number: 20170258579Abstract: A system and method for inserting an intraocular lens in a patient's eye includes a light source for generating a light beam, a scanner for deflecting the light beam to form an enclosed treatment pattern that includes a registration feature, and a delivery system for delivering the enclosed treatment pattern to target tissue in the patient's eye to form an enclosed incision therein having the registration feature. An intraocular lens is placed within the enclosed incision, wherein the intraocular lens has a registration feature that engages with the registration feature of the enclosed incision. Alternately, the scanner can make a separate registration incision for a post that is connected to the intraocular lens via a strut member.Type: ApplicationFiled: May 22, 2017Publication date: September 14, 2017Inventors: William Culbertson, Mark S. Blumenkranz, David Angeley, George R. Marcellino, Michael W. Wiltberger, Dan Anderson
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Patent number: 9750640Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.Type: GrantFiled: August 16, 2016Date of Patent: September 5, 2017Assignee: Optimedica CorporationInventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
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Patent number: 9724233Abstract: Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue.Type: GrantFiled: April 13, 2015Date of Patent: August 8, 2017Inventors: Mark S. Blumenkranz, Edward E. Manche, Satish V. Herekar, Donald J. Eaton
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Patent number: 9693905Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.Type: GrantFiled: August 16, 2016Date of Patent: July 4, 2017Assignee: OptiMedica CorporationInventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
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Patent number: 9693904Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.Type: GrantFiled: August 12, 2016Date of Patent: July 4, 2017Assignee: OptiMedica CorporationInventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen
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Patent number: 9693903Abstract: A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.Type: GrantFiled: August 12, 2016Date of Patent: July 4, 2017Assignee: Optimedica CorporationInventors: Daniel V. Palanker, Mark S. Blumenkranz, David H. Mordaunt, Dan E. Andersen