Patents by Inventor Mark S. Eller
Mark S. Eller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8183222Abstract: Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.Type: GrantFiled: March 1, 2010Date of Patent: May 22, 2012Assignee: Trustees of Boston UniversityInventors: Barbara A. Gilchrest, Mark S. Eller
-
Publication number: 20110237654Abstract: Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful for treating other cancers, such as for example pancreatic cancer and eradicating cancer stem cells.Type: ApplicationFiled: January 18, 2011Publication date: September 29, 2011Applicant: Trustees of Boston UniversityInventors: Barbara A. Gilchrest, Mark S. Eller
-
Publication number: 20100286247Abstract: Alterations in the structure of telomeres lead to modulation in the redox state of the cell. Substances which mimic destabilized telomeres, such as t-oligos, have a protective effect on future exposure of a cell to oxidative stress.Type: ApplicationFiled: April 4, 2006Publication date: November 11, 2010Applicant: Trustees of Boston UniversityInventors: Barbara A. Gilchrest, Mark S. Eller, Mina Yaar, Margaret S. Lee-Bellantoni
-
Publication number: 20100249218Abstract: Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.Type: ApplicationFiled: March 1, 2010Publication date: September 30, 2010Applicant: Trustees of Boston UniversityInventors: Barbara A. GILCHREST, Mark S. Eller
-
Publication number: 20100222419Abstract: Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.Type: ApplicationFiled: February 19, 2010Publication date: September 2, 2010Applicant: TRUSTEES OF BOSTON UNIVERSITYInventors: BARBARA A. GILCHREST, Mark S. Eller
-
Publication number: 20100093716Abstract: The present invention provides, inter alia, compositions and methods for treating various diseases and disorders in a mammal by administering to a mammal in need an effective amount of a composition comprising a non-DNA small molecule that binds WRN, such as members of the spirooxindole (SPOX) class.Type: ApplicationFiled: August 29, 2007Publication date: April 15, 2010Applicant: TRUSTEES OF BOSTON UNIVERSITY AND PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Barbara A. Gilchrest, Mark S. Eller, Angela N. Koehler, Olivia M. McPherson, Christopher S. Neumann, Timothy A. Lewis
-
Publication number: 20090209747Abstract: Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising one or more oligonucleotides which share at least 33% but less than 100% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperprolferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed. The compositions and methods are also useful to treating other cancers.Type: ApplicationFiled: November 20, 2008Publication date: August 20, 2009Applicant: Trustees of Boston UniversityInventors: Barbara A. Gilchrest, Mark S. Eller
-
Publication number: 20080221052Abstract: The use of modulators of WRN is described. Activators of WRN may be used to induce growth arrest, apoptosis or proliferative senescence, whereas inhibitors of WRN may be used to reduce growth arrest, apoptosis or proliferative senescence. Methods of identifying modulators of WRN are also described.Type: ApplicationFiled: May 19, 2005Publication date: September 11, 2008Inventors: Barbara A. Gilchrest, Mark S. Eller
-
Patent number: 7196055Abstract: Methods to control, or manipulate, melanocyte and keratinocyte cell death are disclosed. In particular, a method of preventing epidermal melanocyte cell loss due to injury in a vertebrate is disclosed. Also disclosed is a method of inducing hair growth in a vertebrate, a method of inducing hair color in a vertebrate, a method of inducing skin color in a vertebrate, a method of treating baldness in an individual, and a method of treating alopecia areata in an individual.Type: GrantFiled: February 4, 1998Date of Patent: March 27, 2007Assignee: Trustees of Boston UniversityInventors: Barbara A. Gilchrest, Mina Yaar, Mark S. Eller
-
Patent number: 7033829Abstract: Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.Type: GrantFiled: April 12, 2002Date of Patent: April 25, 2006Assignee: Trustees of Boston UniversityInventors: Barbara A. Gilchrest, Mark S. Eller, Mina Yaar
-
Publication number: 20030032610Abstract: Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.Type: ApplicationFiled: April 12, 2002Publication date: February 13, 2003Inventors: Barbara A. Gilchrest, Mark S. Eller, Mina Yaar
-
Publication number: 20030032611Abstract: Described are methods for treating hyperproliferative disorders, including cancers, by administering to the affected mammal (e.g., human) an effective amount of a composition comprising pTT or a composition comprising one or more oligonucleotides which share at least 50% nucleotide sequence identity with the human telomere overhang repeat. Methods of treatment or prevention of hyperproliferative diseases or pre-cancerous conditions affecting epithelial cells, such as psoriasis, atopic dermatitis, or hyperproliferative or UV-responsive dermatoses, hyperproliferative diseases of other epithelia and methods for reducing photoaging, or oxidative stress or for prophylaxis against or reduction in the likelihood of the development of skin cancer, are also disclosed.Type: ApplicationFiled: April 12, 2002Publication date: February 13, 2003Inventors: Barbara A. Gilchrest, Mark S. Eller, Mina Yaar