Abstract: The effect of laser stimulation, e.g., R:GEN, of the RPE and its impact on MMPs and RAAS pathways are used to guide patient therapies. Certain biomarkers, namely MMPs, TIMPs, and components associated with RAAS, are effective indicators of healing response levels generated by the patients undergoing the therapy. An eye disease is diagnosed in a patient and a first biomarker sample is obtained from a biomatrix, e.g., patient's blood in containers with protease inhibitors. An initial subthreshold laser treatment is then performed on the eye. By monitoring the presence, amount, and relative levels of one or more of the above biomarkers as the patient heals, it is determined when the patient's body has sufficiently responded to the previous treatment, such that retreatment may be appropriate. The present disclosure demonstrates effective treatment of eye diseases, e.g., dry age-related macular degeneration, which utilize laser treatment alone or in combination with other treatments.

Abstract: The system comprises a wearable, electronic image acquisition and processing system (or visual enhancement system) to guide visually impaired individuals through their environment, providing information to the user about nearby objects of interest, potentially dangerous obstacles, their location, and potential paths to their destination.