Patents by Inventor Mark S. Humayun

Mark S. Humayun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200085995
    Abstract: The present disclosure describes, among other things, a thereto-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.
    Type: Application
    Filed: November 25, 2019
    Publication date: March 19, 2020
    Inventors: John J. WHALEN, III, Niki BAYAT, Yi ZHANG, Paulo FALABELLA, Mark E. THOMPSON, Mark S. HUMAYUN
  • Publication number: 20200077641
    Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.
    Type: Application
    Filed: August 30, 2019
    Publication date: March 12, 2020
    Applicants: University of Southern California, The Regents of the University of California
    Inventors: Britney O. Pennington, Jeffrey K. Bailey, Mohamed A. Faynus, Cassidy Arnold, Lincoln V. Johnson, Dennis O. Clegg, Mark S. Humayun, David R. Hinton, Danhong Zhu, Debbie Mitra
  • Publication number: 20200045957
    Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
    Type: Application
    Filed: October 21, 2019
    Publication date: February 13, 2020
    Applicant: University of Southern California
    Inventors: Danhong Zhu, David R. Hinton, Ashish Ahuja, Mark S. Humayun
  • Patent number: 10512707
    Abstract: The present disclosure describes, among other things, a thermo-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.
    Type: Grant
    Filed: February 2, 2016
    Date of Patent: December 24, 2019
    Assignee: University of Southern California
    Inventors: John J. Whalen, III, Niki Bayat, Yi Zhang, Paulo Falabella, Mark E. Thompson, Mark S. Humayun
  • Publication number: 20190374381
    Abstract: An eye treatment apparatus is described. The apparatus includes an annular body that has a hollow optical zone in its center. An inner perimeter of the annular body surrounds the optical zone. The inner perimeter has a diameter that corresponds to a diameter of the eye's cornea. An outer perimeter of the annular body has a diameter such that the annular body can extend to underneath the eye lid in an open eye position when the eye treatment apparatus is in operation. In this way, the apparatus can be worn on the eye, where the hollow optical zone substantially corresponds to the cornea and does not interfere with the field of vision. The annular body also includes a storage chamber that stores therapeutic liquid for an eye. An outlet is coupled with the storage chamber such that, in operation, the therapeutic liquid can be dispensed to the eye.
    Type: Application
    Filed: June 11, 2019
    Publication date: December 12, 2019
    Applicants: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Colin A. Cook, Mark S. Humayun
  • Publication number: 20190358082
    Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.
    Type: Application
    Filed: May 21, 2019
    Publication date: November 28, 2019
    Applicants: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Aubrey M. Shapero, Nicholas E. Scianmarello, Mark S. Humayun
  • Publication number: 20190307928
    Abstract: A polymeric substrate for treating a chondral or osteochondral defect includes a polymeric sheet having a predetermined shape and size for placement over a chondral or osteochondral defect. The polymeric sheet defines suture openings therein that allow fixation of the polymeric scaffold. Characteristically, the polymeric sheet includes biocompatible polymer. A method for treating a subject having a chondral or osteochondral defect is also provided.
    Type: Application
    Filed: April 8, 2019
    Publication date: October 10, 2019
    Inventors: Mark S. Humayun, Carlos Eduardo da Silveira Franciozi, Tzu-Chieh Chou, Yu-Chong Tai, Damien C. Rodger, C. Thomas Vangsness, JR.
  • Patent number: 10406227
    Abstract: Methods and compositions modulate the activity of electrically excitable cells. Photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells. These supplement and/or replace of vision based on the conversion of light energy to electrical energy within certain cells of the visual system. A “patch” or bridge to circumvent one or more defective, damaged, or diseased cells in the visual system. Additionally, in several embodiments, subjects with normal vision can benefit from the methods, compositions, systems, and/or devices disclosed herein as normal visual acuity can be heightened. The exposure induces an energy (e.g., a receipt of light energy, conversion to electrical energy, and passage of that electrical energy) from the photovoltaic compound to the cell, thereby altering the transmembrane potential of the cell and/or the opening of one or more ion channels, thereby modulating the activity of the electrically excitable cell.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: September 10, 2019
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Robert H. Chow, Mark S. Humayun, Harry B. Gray, Robert H. Grubbs, Dennis A. Dougherty, Mark E. Thompson, Lionel E. Cheruzel, Melanie A. Yen
  • Publication number: 20190254705
    Abstract: A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.
    Type: Application
    Filed: February 20, 2019
    Publication date: August 22, 2019
    Applicant: University of Southern California
    Inventor: Mark S. Humayun
  • Publication number: 20190246986
    Abstract: A portable apparatus for imaging an eye in a patient includes a housing with a front portion and a rear portion, the front portion including an adapter sized to be placed over the eye of the patient. A lens is mounted within the housing, and a light source is provided within the housing to illuminate the eye. The rear portion of the housing is arranged to be mounted on a mobile device such that the lens is aligned with a camera associated with the mobile device for obtaining an image of the eye.
    Type: Application
    Filed: September 8, 2017
    Publication date: August 15, 2019
    Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA
    Inventors: Damien C. RODGER, Mark S. HUMAYUN, Peiyu WANG
  • Patent number: 10342698
    Abstract: An implantable medical device is described. The implantable medical device includes a small molecule generator, a small molecule diffusor, and a cannula that connects the two. The small molecule generator includes an electrolyte reservoir and a set of electrodes. A first portion of the electrolyte reservoir is impermeable to a predetermined class of small molecules. A second portion of the electrolyte reservoir is permeable to the small molecules. The set of electrodes is disposed inside the electrolyte reservoir and is configured to facilitate electrolysis of the small molecules based on an electric power application to the set of electrodes and on presence of electrolyte inside the electrolyte reservoir. At least a portion of the small molecule diffusor is permeable to the small molecules.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: July 9, 2019
    Assignees: CALIFORNIA INSTITUTE OF TECHNOLOGY, UNIVERSITY OF SOUTHERN CALIFORNIA, DOHENY EYE INSTITUTE
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Karthik Murali, Mark S. Humayun, Ramiro Magalhaes Ribeiro
  • Publication number: 20190151499
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Application
    Filed: December 17, 2018
    Publication date: May 23, 2019
    Applicants: University of Southern California, California Institute of Technology, The Regents of the University of California
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • Patent number: 10251780
    Abstract: A three-coil electromagnetic induction power transfer system is disclosed for epiretinal prostheses and other implants. A third, buffer coil is disposed between an external transmitting coil and a receiver coil buried within the body to improve efficiency and robustness to misalignments. One or more of the coils can be manufactured using micromechanical machining techniques to lay out conductors in a ribbon of biocompatible insulator, folding lengths of the insulated conductor traces longitudinally over one another, and then spiraling them into a ring. The traces change axial position in the ring by shifting across fold lines. One or more U-shaped sections on the traces can be folded so that adjacent traces can project opposite one another, lengthening the resulting ribbon that can be wound into a coil.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: April 9, 2019
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Yu Zhao, Mark S. Humayun, James D. Weiland
  • Patent number: 10232043
    Abstract: Disclosed herein are methods and compositions for the modulation of the activity of electrically excitable cells. In particular, several embodiments relate to the use of photovoltaic compounds which, upon exposure to light energy, increase or decrease the electrical activity of cells.
    Type: Grant
    Filed: August 18, 2016
    Date of Patent: March 19, 2019
    Assignees: California Institute of Technology, University of Southern California
    Inventors: Melanie A. Yen, Dennis A. Dougherty, Robert H. Grubbs, Harry B. Gray, Robert H. Chow, Mark S. Humayun, Mark E. Thompson, Lionel E. Cheruzel
  • Patent number: 10201697
    Abstract: The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad.
    Type: Grant
    Filed: November 27, 2017
    Date of Patent: February 12, 2019
    Assignee: Second Sight Medical Products, Inc.
    Inventors: Robert J Greenberg, Eugene de Juan, Mark S Humayun, Kelly McClure, Neil Hamilton Talbot, Jordan Matthew Neysmith, Brian V Mech, James Singleton Little, Mohamed Khaldi
  • Patent number: 10188769
    Abstract: Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
    Type: Grant
    Filed: June 25, 2014
    Date of Patent: January 29, 2019
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, CALIFORNIA INSTITUTE OF TECHNOLOGY, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Mark S. Humayun, Ashish Ahuja, Yu-Chong Tai, David R. Hinton, Robert H. Grubbs, Dennis O. Clegg, Lincoln Vallance Johnson, Sherry T. Hikita
  • Patent number: 10188853
    Abstract: The present invention is a flexible circuit electrode array with a polymer base layer, metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue, a polymer top layer deposited on the polymer base layer and the metal traces, and a soft polymer filling a void through both the polymer base layer and polymer top layer, the soft polymer forming drum stress relief around an attachment point.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: January 29, 2019
    Assignee: Second Sight Medical Products, Inc.
    Inventors: Rajat Agrawal, Robert J. Greenberg, Mark S. Humayun, James Singleton Little, Brian V. Mech, Jordan Matthew Neysmith, Neil Hamilton Talbot, Dao Min Zhou
  • Patent number: 10188843
    Abstract: The present disclosure described methods, systems, and techniques for applying contrast-enhanced ultrasound to locate areas of blockage within retinal vessels and to break up clots that are causing damage. In addition to identifying the damaged area, the researchers anticipate that the initial image may serve as a baseline for monitoring the effect of treatment on the vessel, which may be achieved in multiple ways. The vibration effect of the ultrasound itself may suffice to dislodge clots. The microbubbles may also be coated or filled with medication, with ultrasonic shock waves activating the coating or causing mini explosions to release the medicine. Loading the microbubbles with a therapeutic agent, visualizing their presence at the diseased site using the ultrasound diagnostic mode, and then activating the microbubbles to release their contents at the targeted lesion could be a powerful and effective way to reverse occlusion without harming other areas of the eye or body.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: January 29, 2019
    Assignees: UNIVERSITY OF SOUTHERN CALIFORNIA, DOHENY EYE INSTITUTE
    Inventors: Amani Fawzi, Hossein Ameri, Mark S. Humayun
  • Publication number: 20190025610
    Abstract: A contact lens fluid delivery device having a liquid reservoir connected to a channel with a flow regulator is described. Other eye hydration and variable dioptric power contact lenses are described herein. Also described are implantable liquid delivery apparatuses having a liquid storage reservoir connected to a channel with a flow regulator. These devices and apparatuses are useful for specific, targeted delivery of therapeutic liquids within a subject. In some embodiments, the devices incorporate actuation chambers which provide a driving force releasing the fluid into the targeted area e.g., the eye. The actuation chambers described herein can contain phase change materials or osmotic chambers or a combination thereof to drive the release of fluid.
    Type: Application
    Filed: June 25, 2018
    Publication date: January 24, 2019
    Applicants: California Institute of Technology, University of Southern California
    Inventors: Yu-Chong Tai, Nicholas E. Scianmarello, Charles M. T. DeBoer, Mark S. Humayun
  • Publication number: 20180325373
    Abstract: A miniature, low power electronic pressure sensor with a first, oil-filled chamber to protect its microelectromechanical systems (MEMS) pressure sensitive membrane and a second chamber filled with saline or body fluids connected by tube into an organ in the body, such as an eyeball, that needs pressure sensing, is described. The tube carries pressure from a sensitive area within the organ to the electronic pressure sensor. The pressure sensor may communicate wirelessly with external readers and pass data to a server or other computer. Running alongside the tube is another tube for draining and pressure relief. The tubes, or cannulas, can share an opening into the organ in order to minimize the number of holes needed. The tubes may be molded into a single oval cross section, combined coaxially, or share a lumen for a portion that enters the wall of an organ so as to promote healing.
    Type: Application
    Filed: April 9, 2018
    Publication date: November 15, 2018
    Applicants: California Institute of Technology, University of Southern California
    Inventors: Damien C. Rodger, Yu-Chong Tai, Mark S. Humayun, Aubrey M. Shapero, Abhinav Agarwal, Azita Emami