Abstract: Methods, systems, and apparatus for causing changes to cells or tissue within or adjacent to an eye. The system includes an external RF coil configured to transmit RF signals. The system also includes a wearable device configured to be removably disposed on the eye, the wearable device including a plurality of internal radiofrequency (RF) coils configured to receive the RF signals from the external RF coil and a plurality of stimulating electrodes configured to electromagnetically stimulate a portion of the eye or an area adjacent to the eye, causing changes to cells or tissue within or adjacent to the eye.

Abstract: Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

Abstract: Present implementations can include a high-precision neural stimulation device with a high voltage ASIC with an array of transmit control cells, a 2D array of ultrasound transducers, and a coupling for interfacing the high voltage ASIC to the 2D array, where the high voltage ASIC is disposed to receive and store programmable voltage levels. A contact lens structure can include the high-precision neural stimulation device and one or more fluid channels at least partially surrounding the high-precision neural stimulation device.

Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.

Abstract: Disclosed herein are methods and compositions for the identification of viability enhancing cell features and substrate features as they relate to post-cryopreservation survival of substrate seeded cells. Embodiments of the present invention further involve identification of cell features to manufacture a supernatant that is useful for cell culturing and treatment of various diseases.

Abstract: A system and method are disclosed for causing or enhancing the perception of color in a blind or visually impaired person. The system may comprise: an electromagnetic stimulation device associated with the blind or visually impaired person; and a visualization device for receiving an image and detecting a color of an object in the image, wherein the electromagnetic stimulation device is configured to stimulate the blind or visually impaired person based on a parameter of electromagnetic stimulation that varies based on the color detected by the visualization device. The method may comprise: varying a parameter of electromagnetic stimulation of an electromagnetic stimulation device, associated with an eye of the blind or visually impaired person, based on which color is detected by a visualization device that is used in conjunction with the electromagnetic stimulation device; and stimulating the eye with the electromagnetic stimulation device according to the parameter of electromagnetic stimulation.

Abstract: A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

Abstract: Several embodiments disclosed herein relate to compositions and methods for treating or repairing damage to ocular tissue. In particular, several embodiments relate to patches that interact, e.g., by way of an adhesive, with damaged retinal tissue to repair or mend a hole, tear or detachment of the retina from underlying ocular tissue. Still additional embodiments relate to self-assembling patches.

Abstract: A lacrimal tear flow measurement device, and methods of manufacture and use, are described that includes a polymer microcapillary tube or similar structure having at least one end coated on the outside with soft silicone rubber and one end treated on the inside to be hydrophobic. The hydrophobic end keeps liquid from escaping or entering that end while allowing air to pass. The rest of the tube's insides may be hydrophilic or a neutral hydrophobe. As a Schirmer's test strip replacement, the entrance end of the device can be touched to the lacrimal lake of a patient's eye to collect suck up, or merely collect, tear fluid within the collection tube for weighing, volume measurement, or other analysis. Long-term collection devices for wear between doctors' visits can have a bypass channel allowing liquid to flow back onto the eye.

Abstract: The disclosure provides a rapidly deployable nanoscale biodegradable system using hydroxypropyl beta cyclodextrin based combination product. Cyclodextrin is an amphiphilic polymer suitable to develop an agnostic barrier blocking pathogenic mi-crobes that has localized on the mucocutaneous lining of the conjunctiva, mouth and nose, lung, or gastrointestinal tract. The cyclodex-trin may bind the viral particles and/or disrupt viral entry mechanisms by removing cholesterol from viral particles to reduce infectivity. Cyclodextrins also may facilitate removal of the viral cholesterol molecules, thus rendering them less viable. Cyclodextrin activity may be further enhanced when used in combination with certain minerals and/or antioxidant compounds.

Abstract: An ophthalmic liquid delivery apparatus includes a bulbar conjunctiva contacting surface, a palpebral conjunctiva contacting surface which is opposite the bulbar conjunctiva contacting surface, a therapeutic storage reservoir, and at least one fluid delivery port. In addition, a fill system for a liquid filled device includes a liquid feed tube, a plug rod feed tube, a junction port for the liquid feed tube and plug rod feed tube to meet, a needle output to temporarily interface with an ophthalmic liquid delivery device during the filling and plug step, and a cutting tool to cut the plug rod once the device is filled.

Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

Abstract: A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.

Abstract: Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.

Abstract: A microfluidic flow restrictor that uses micron-sized beads to impede flow is described. The flow rate can be adjusted by adding or removing the beads using injection needles through self-sealing ports, one injection needle injecting or aspirating beads and another injection needle pushing or pulling fluid from outside of a bead trap within the flow restrictor. In alternative embodiments, the beads or other filler material can be trapped in a manifold bead trap such that they block a subset of fluid channels of the flow restrictor, allowing fluid to flow freely through the rest of the fluid channels. The flow restrictor can be integrated with a contact lens or implantable medical device for use in dispensing liquid therapeutic agents at flow rates of microliters per minute or moving body fluids at a controlled rate from one part of the body to another.

Abstract: A surgical instrument, and methods for its use, is described that includes clamp heads that can be nestled within or extended from a tubular sheath by longitudinal movement of the clamp heads' tines with respect to the tubular sheath. One of the tines includes an arch that slides against a mouth and inside wall of the tubular sheath, causing the clamp heads to open or close. The clamp heads close lightly, to within a predetermined (or zero) distance from one another, gently grasp an ultrathin polymer substrate seeded with cells, and pulls it within the sheath such that the substrate curls and folds to protect the cells.

Abstract: Bioelectronic lens (E-lens) systems for inducing neuroprotective changes in neurons, in particular the retina. A system may include a stimulating electrode configured to be placed on an eye or skin around the eye. The system may further include a return electrode configured such that voltage distribution is focalized to the eye and induced electric fields to an area of interest on the eye or on the skin around the eye are maximized. The electric fields provide neuroprotection and reinnervation.

Abstract: The present disclosure describes, among other things, a thereto-responsive hydrogel comprising a PNIPAM copolymer having adhesive properties that are temperature dependent, as well as a device for administering the hydrogel, and methods for making and using the foregoing.

Abstract: An ophthalmic device for illuminating an interior region of a patient's eye includes a polymeric, at least partially transparent body having a first surface contoured to substantially conform to an ocular surface and a second surface opposed to the first surface; a light source; and an optical element for directing light through the first surface such that, with the first surface in contact with a corneal surface of the patient's eye, a portion of interior region of the patient's eye illuminated by the light source is visible through the first and second surfaces. In certain embodiments, the light source is sufficient to illuminate the retina so that an ophthalmic surgeon may view the eye during an evaluation or surgical procedure without the need for invasive probes, cameras, or other equipment.

Abstract: An augmented reality system for providing depth perspective includes a sensor system that provides spatial data of objects in a surrounding environment of a user. A computer processor system calculates spatial information of the objects from the spatial data received the sensor system. The computer processor system determines a depth-to-color mapping in which distance of objects from the user is mapped to a predetermined viewable representation. The system also includes a head mountable display that displays the depth-to-color mapping to the user. Characteristically, distances of the objects from the user are rendered to allow at least partial viewability of the object by the user. A method utilizing the augmented reality system is also provided.