Patents by Inventor Mark S. Kirby

Mark S. Kirby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 11?hydroxysteroid dehydrogenase type 1
    Patent number: 8420365
    Abstract: The invention provides gene-targeted non-human animals comprising a genetically modified 11?HSD1 gene encodes a mutant 11?HSD1 polypeptide which is modulated by human 11?HSD1 modulating compounds. The invention further provides cells expressing mutant 11?HSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11?HSD1. The invention further provides methods of identifying agents that modulate 11?HSD1 activity, and are useful to treat 11?HSD1-related metabolic disorders.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: April 16, 2013
    Assignee: Bristol-Myers Squibb Company
    Inventors: David Gordon, Yuval Blat, Akbar Nayeem, Mark S. Kirby, Bin He
  • 11 BETA HYDROXYSTEROID DEHYDROGENASE TYPE 1
    Publication number: 20100209990
    Abstract: The invention provides gene-targeted non-human animals comprising a genetically modified 11?HSD1 gene encodes a mutant 11?HSD1 polypeptide which is modulated by human 11?HSD1 modulating compounds. The invention further provides cells expressing mutant 11?HSD1 and cells isolated from gene-targeted animals, which cells produce a mutant 11?HSD1. The invention further provides methods of identifying agents that modulate 11?HSD1 activity, and are useful to treat 11?HSD1-related metabolic disorders.
    Type: Application
    Filed: October 8, 2008
    Publication date: August 19, 2010
    Inventors: David Gordon, Yuval Blat, Akbar Nayeem, Mark S. Kirby, Bin He
  • Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
    Patent number: 6995183
    Abstract: Compounds are provided having the formula (I) wherein: n is 0, 1 or 2; m is 0, 1 or 2; the sum of n+m less then or equal to 2; the dashed bonds forming a cyclopropyl ring can only be present when Y is CH; X is H or CN; Y is CH, CH2, CHF, CF2, O, S, SO, or SO2; and A is adamantyl. Further provided are methods of using such compounds for the treatment of diabetes and related diseases, and to pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: July 27, 2004
    Date of Patent: February 7, 2006
    Assignee: Bristol Myers Squibb Company
    Inventors: Lawrence G. Hamann, Ashish Khanna, Mark S. Kirby, David R. Magnin, Ligaya M. Simpkins, James C. Sutton, Jeffrey Robl
  • Method and apparatus for measurement of ice thickness employing ultra-sonic pulse echo technique
    Patent number: 4628736
    Abstract: Method and apparatus for measurement of ice thickness employing ultra-sonic pulse echo technique, wherein an ultra-sonic pulse is emitted from a transducer at the ice-accreting surface of a structure, the pulse is reflected at the periphery of the accreted ice and the reflection is detected. The time delay is calibrated and related to ice thickness and accretion rate.
    Type: Grant
    Filed: January 14, 1985
    Date of Patent: December 16, 1986
    Assignee: Massachusetts Institute of Technology
    Inventors: Mark S. Kirby, Robert J. Hansman, Jr.