Patents by Inventor Mark S. Marshall

Mark S. Marshall has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibiting protein interactions
    Patent number: 6103692
    Abstract: The invention discloses methods of inhibiting direct binding of Ras with Raf and screening methods to identify compounds which inhibit direct binding of Ras to Raf, Raf activation, and cell proliferation.
    Type: Grant
    Filed: March 11, 1997
    Date of Patent: August 15, 2000
    Assignee: The General Hospital Corporation
    Inventors: Joseph Avruch, Zhujun Luo, Mark S. Marshall
  • Inhibiting protein interactions
    Patent number: 5767075
    Abstract: Disclosed is a method of evaluating an anti-proliferative compound by contacting the compound with a Raf and determining its ability to bind to Ras, and methods of inhibiting cell proliferation in an animal by administering a compound which reduces the interaction of Ras with Raf.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 16, 1998
    Assignees: The General Hospital Corporation, Indiana University Foundation
    Inventors: Joseph Avruch, Xian-feng Zhang, Mark S. Marshall
  • Inhibiting protein interactions
    Patent number: 5763571
    Abstract: Disclosed are Ras-binding peptides and peptide mimetics thereof which inhibit the direct binding of Ras with Raf and contain an amino acid sequence with 80-100% identity to the sequence of specific Raf fragments.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: June 9, 1998
    Assignees: The General Hospital Corporation, Indiana University Foundation
    Inventors: Joseph Avruch, Xian-feng Zhang, Mark S. Marshall
  • Inhibiting protein interactions
    Patent number: 5736337
    Abstract: Disclosed is a method of evaluating an anti-proliferative compound by contacting the compound with a Raf and determining its ability to bind to Ras, and methods of inhibiting cell proliferation in an animal by administering a compound which reduces the interaction of Ras with Raf.
    Type: Grant
    Filed: June 10, 1994
    Date of Patent: April 7, 1998
    Assignees: The General Hospital Corporation, Indiana University Foundation
    Inventors: Joseph Avruch, Xian-feng Zhang, Mark S. Marshall