Patents by Inventor Mark S. Shapiro

Mark S. Shapiro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CD73 compounds
    Patent number: 12110294
    Abstract: The present disclosure provides pyrimidine dione compounds of Formula I and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.
    Type: Grant
    Filed: April 29, 2021
    Date of Patent: October 8, 2024
    Assignee: Gilead Sciences, Inc.
    Inventors: Mark J. Bartlett, Gregory F. Chin, Michael O. Clarke, Jennifer L. Cosman, Deeba Ensan, Bindu Goyal, Stephen Ho, Hon C. Hui, Richard L. Mackman, Michael R. Mish, Scott D. Schroeder, Nathan D. Shapiro, Dustin S. Siegel, Doris T. Tang, Hai Yang
  • Method for the Prevention of Brain Damage after Traumatic Brain Injury by Pharmacological Enhancement of KCNQ Potassium Ion Channels in Neurons
    Publication number: 20200297275
    Abstract: A method for the prevention of brain damage and dysfunction after blunt or blast types of TBI by a single systemic dose application either intravenous (i.v.) or intraperitoneal (i.p.) of a pharmacological “opener” of KCNQ (“M-type”) potassium ion channels in brain.
    Type: Application
    Filed: January 22, 2020
    Publication date: September 24, 2020
    Inventor: Mark S. Shapiro
  • Method for the Prevention of Brain Damage after Traumatic Brain Injury by Pharmacological Enhancement of KCNQ Potassium Ion Channels in Neurons
    Publication number: 20200297276
    Abstract: A method for the prevention of brain damage and dysfunction after blunt or blast types of TBI by a single systemic dose application either intravenous (i.v.) or intraperitoneal (i.p.) of a pharmacological “opener” of KCNQ (“M-type”) potassium ion channels in brain.
    Type: Application
    Filed: February 24, 2020
    Publication date: September 24, 2020
    Inventors: Mark S. Shapiro, Fabio A. Vigil