Patents by Inventor Mark S Sliwkowski

Mark S Sliwkowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heregulin variants
    Patent number: 7563583
    Abstract: The present invention provides heregulin variants that are capable of binding an ErbB receptor. Included in the invention are variants of human heregulins, and, in particular, variants of human heregulin-?1 having enhanced affinity for the ErbB-3 and ErbB-4 receptors. These variants include at least one amino acid substitution and can include further modifications. The invention also provides nucleic acid molecules encoding heregulin variants and related vectors, host cells, pharmaceutical compositions, and methods.
    Type: Grant
    Filed: February 2, 2006
    Date of Patent: July 21, 2009
    Assignee: Genentech, Inc.
    Inventors: Marcus D Ballinger, Jennifer T Jones, Wayne J Fairbrother, Mark S Sliwkowski, James A Wells