Abstract: The present invention is directed to a method and apparatus for detecting foam in a specimen container. The method includes the following steps: transporting a specimen container into a locator well; centering the specimen container in the locator well; rotating the specimen container around a vertical axis in the locator well; imaging the specimen container during the rotation; analyzing an image of the specimen container captured during the rotation; and detecting foam in the specimen container based on the analysis of the image. An apparatus configured to perform the steps is also provided. The method and apparatus may be used in conjunction with a system for automatically determining whether a sample is positive for microorganism growth.

Abstract: Systems and apparatus with circuits that are configured to detect fallen containers upstream or proximate an intake zone suitable for automated evaluation apparatus using different sensors, including at least one lower sensor and at least one upper sensor which is positioned to project an optical signal at a height corresponding to a top portion of an upright container to thereby allow an increased reliability in detection of different orientations and positions of fallen containers. An optional second lower sensor may be used which is longitudinally spaced apart from the first lower sensor and the lower sensors can transmit optical signals across the container travel path that do not intersect.

Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

Abstract: A separation container for extracting a portion of a sample for use or testing and method for preparing samples for downstream use or testing are provided. The separation container may include a body defining an internal chamber. The body may define an opening, and the body may be configured to receive the sample within the internal chamber. The separation container may further include a seal disposed across the opening, such that the seal may be configured to seal the opening of the body, and a plunger movably disposed at least partially inside the internal chamber. The plunger may be configured to be actuated to open the seal and express the portion of the sample.

Abstract: Systems and apparatus with circuits that are configured to detect fallen containers upstream or proximate an intake zone suitable for automated evaluation apparatus using different sensors, including at least one lower sensor and at least one upper sensor which is positioned to project an optical signal at a height corresponding to a top portion of an upright container to thereby allow an increased reliability in detection of different orientations and positions of fallen containers. An optional second lower sensor may be used which is longitudinally spaced apart from the first lower sensor and the lower sensors can transmit optical signals across the container travel path that do not intersect.

Abstract: Apparatus for automated venting and/or sampling of a specimen container having a closure sealing the interior of the specimen container from the environment is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle and a port in fluid communication with the chamber; a robotic transfer mechanism movable relative to the rack; a sample removal apparatus attached to the robotic transfer mechanism having gripping features for gripping the venting device.

Abstract: A handle assembly for a container, the container having a pivotally mounted pressure plate for dispensing a seaming compound, includes a connector plate configured for removably coupling to the pressure plate, a first handle for gripping with a first hand of a user, and a second handle for gripping with a second hand of the user. Each of the first handle and the second handle is coupled to the connector plate.

Abstract: A device and method for determining antimicrobial resistance status of a microorganism from a positive sample bottle is provided. The device may include a housing having a chamber for receiving a vial containing a sample; a light source positioned to direct light through a side of the chamber; and a photodetector positioned such that light transmitted or scattered by the sample is sensed by the photodetector. The device may also include a heat source and/or an agitation device. The method includes providing the device, loading a sample from an automated sample culture system into the vial; interrogating the vial using the light source and the photodetector; and determining the antimicrobial resistance status of the microorganism in the sample based on the interrogating step. The method may also include heating and/or agitating the sample.

Abstract: Apparatus for automated venting and/or sampling of a specimen container having a closure sealing the interior of the specimen container from the environment is disclosed. The apparatus includes a rack holding the specimen container; a venting and/or sampling device having a needle, a chamber in fluid communication with the needle and a port in fluid communication with the chamber; a robotic transfer mechanism moveable relative to the rack; a sample removal apparatus attached to the robotic transfer mechanism having gripping features for gripping the venting device.

Abstract: Methods, systems, computer program products, apparatus and circuits are configured to detect fallen containers upstream or proximate an intake zone suitable for automated evaluation apparatus using different sensors, including at least one lower sensor and at least one upper sensor which is positioned to project an optical signal at a height corresponding to a top portion of an upright container to thereby allow an increased reliability in detection of different orientations and positions of fallen containers. An optional second lower sensor may be used which is longitudinally spaced apart from the first lower sensor and the lower sensors can transmit optical signals across the container travel path that do not intersect.

Abstract: A detection instrument determines whether a specimen container (e.g., blood culture bottle) is positive for presence of microbial agent growth therein. When the container is deemed positive it is made available (e.g, transferred or exposed to) to an automated instrument performing identification and/or characterization of the microbial agent. The identification and/or characterization instrument removes a portion of the sample from the specimen container and places it into a disposable separation and concentration device. The microbial agent is concentrated via optional selective lysis of non-microbial agent cellular material which may be present and centrifugation. A reading module reads the concentrated microbial agent using spectroscopic methods, e.g., measurements of intrinsic fluorescence. Such interrogation may occur while the microbial agent remains concentrated in the disposable device.

Abstract: The present invention is directed to a method and apparatus for detecting foam in a specimen container. The method includes the following steps: transporting a specimen container into a locator well; centering the specimen container in the locator well; rotating the specimen container around a vertical axis in the locator well; imaging the specimen container during the rotation; analyzing an image of the specimen container captured during the rotation; and detecting foam in the specimen container based on the analysis of the image. An apparatus configured to perform the steps is also provided. The method and apparatus may be used in conjunction with a system for automatically determining whether a sample is positive for microorganism growth.

Abstract: A sampling device for a specimen container having a closure sealing the interior of the specimen container from the environment includes a needle, a body coupled to the needle and defining a chamber in fluid communication with the needle, the body further comprising a port forming an opening in the body, the port in fluid communication with the chamber. A multitude of the sampling devices may be stored in a cassette. The sampling devices may include a second chamber for separation and concentration of a microbial agent present in a sample. In this configuration second chamber is connected to the first chamber via a valve or the like.

Abstract: Methods, systems, computer program products, apparatus and circuits are configured to detect fallen containers upstream or proximate an intake zone suitable for automated evaluation apparatus using different sensors, including at least one lower sensor and at least one upper sensor which is positioned to project an optical signal at a height corresponding to a top portion of an upright container to thereby allow an increased reliability in detection of different orientations and positions of fallen containers. An optional second lower sensor may be used which is longitudinally spaced apart from the first lower sensor and the lower sensors can transmit optical signals across the container travel path that do not intersect.

Abstract: A handle assembly for a container, the container having a pivotally mounted pressure plate for dispensing a seaming compound, includes a connector plate configured for removably coupling to the pressure plate, a first handle for gripping with a first hand of a user, and a second handle for gripping with a second hand of the user. Each of the first handle and the second handle is coupled to the connector plate.

Abstract: A device and method for determining antimicrobial resistance status of a microorganism from a positive sample bottle is provided. The device may include a housing having a chamber for receiving a vial containing a sample; a light source positioned to direct light through a side of the chamber; and a photodetector positioned such that light transmitted or scattered by the sample is sensed by the photodetector. The device may also include a heat source and/or an agitation device. The method includes providing the device, loading a sample from an automated sample culture system into the vial; interrogating the vial using the light source and the photodetector; and determining the antimicrobial resistance status of the microorganism in the sample based on the interrogating step. The method may also include heating and/or agitating the sample.