Abstract: A composition comprising as components a polypeptide IMPI? (including wild type) and/or a polypeptide IMPI?-fusion and at least one antibiotic compound, in particular an aminoglycoside antibiotic, and/or at least one bactericidal compound, wherein the polypeptides, the at least one antibiotic and the at least one bactericidal compound is present in the composition in concentrations which exhibit in combination a synergistic effect against resistant bacteria.

Abstract: A composition comprising as components a polypeptide IMPI? (including wild type) and/or a polypeptide IMPI?-fusion and at least one antibiotic compound, in particular an aminoglycoside antibiotic, and/or at least one bactericidal compound, wherein the polypeptides, the at least one antibiotic and the at least one bactericidal compound is present in the composition in concentrations which exhibit in combination a synergistic effect against resistant bacteria.

Abstract: A polypeptide having at least 70% homology, in particular 80%, 90% or 95% homology to the polypeptide of SEQ ID NO:2 representing the wild-type of the protein insect metalloproteinase inhibitor IMPI? and having at least one mutation at position 35, 36 and/or 39 of the amino acid sequence of IMPI? and the polypeptide having an IC50 value to thermolysine of less than the IC50 value of IMPI? wherein the nonpolar amino acid isoleucine at position 35 of IMPI? is replaced either by a nonpolar amino acid selected from the group consisting of leucine, methionine and phenylalanine or by polar amino acid selected from the group consisting of cysteine, asparagine, glutamine, histidine, lysine and arginine; and/or the nonpolar amino acid isoleucine at position 36 of IMPI? is replaced either by a nonpolar amino acid selected from the group consisting of valine, phenylalanine and tryptophan or by polar amino acid selected from the group consisting of tyrosine, serine, threonine, asparagine, glutamine, histidine, lysine and