Abstract: Disclosed are methods of treating lysosomal storage diseases, including Globoid Cell Leukodystrophy (GSD). GSD is refractory to standard treatments, where even more invasive treatments only provide minor benefits. However, combinations of three treatments can interact synergistically to provide marked extension of life-span and increases in neuronal function. A combination of a primary treatment such as a gene therapy or an enzyme replacement therapy and at least two secondary therapies such as a substrate reduction therapy and an immunomodulation treatment can lead to increased average life expectancy compared to any individual treatment or pair of treatments.

Abstract: An exercise treadmill (20) is described having a number of assembly improvements. In one embodiment, a pivot assembly (50) is provided to allow a treadmill deck (32) to deflect during use. The rear pivot assembly includes a pin (56) transversely mounted on the upper surface of a treadmill frame (22). A pivot block (54) is attached to the deck and includes a lower channel (58) that engages the pin. In another embodiment, an adjustable rear foot assembly (70) is provided having a foot (74) that is rotatable within a mounting block (72). The foot is easily accessed through an upper opening (96) in the treadmill. In yet another embodiment, an air dam (100) is provided between a motor compartment (102) and an adjacent endless belt (28). In still another embodiment, a highly elastic drivebelt (120) is used between a motor assembly (104) and a roller assembly (24) that drives the endless belt (28). Lastly, an embodiment is described in which the treadmill frame (22) is assembled using swaged fasteners (38).

Abstract: The exercise device (10) exercises both the upper and lower body in associated motion, while preventing derailment or other related instability of the lower body linkage, due to the connection and force imparted from the upper body linkage. The device includes a frame (12) which has a forward upright member (20). The axle mounts (30) and (32) are attached to the rear region of the frame (12) and support a transverse axle (34) which is preferably operatively connected to a flywheel (36). The ends of the transverse axle (34) rotatably engage left and right crank arm assemblies (40) and (50) that are coupled to the left and right foot links (60) and (70) so that the foot links travel in an arcuate reciprocal path as the transverse axle rotates. The forward ends (62) and (72) of the foot links terminate in rollers (68) and (78), which engage guide tracks (42) and (52) that are mounted to the frame.

Abstract: The exercise device (10) exercises both the upper and lower body in associated motion, while preventing derailment or other related instability of the lower body linkage, due to the connection and force imparted from the upper body linkage. The device includes a frame (12) which has a forward upright member (20). The axle mounts (30) and (32) are attached to the rear region of the frame (12) and support a transverse axle (34) which is preferably operatively connected to a flywheel (36). The ends of the transverse axle (34) rotatably engage left and right crank arm assemblies (40) and (50) that are coupled to the left and right foot links (60) and (70) so that the foot links travel in an arcuate reciprocal path as the transverse axle rotates. The forward ends (62) and (72) of the foot links terminate in rollers (68) and (78), which engage guide tracks (42) and (52) that are mounted to the frame.

Abstract: The exercise device (10) exercises both the upper and lower body in associated motion, while preventing derailment or other related instability of the lower body linkage, due to the connection and force imparted from the upper body linkage. The device includes a frame (12) which has a forward upright member (20). The axle mounts (30) and (32) are attached to the rear region of the frame (12) and support a transverse axle (34) which is preferably operatively connected to a flywheel (36). The ends of the transverse axle (34) rotatably engage left and right crank arm assemblies (40) and (50) that are coupled to the left and right foot links (60) and (70) so that the foot links travel in an arcuate reciprocal path as the transverse axle rotates. The forward ends (62) and (72) of the foot links terminate in rollers (68) and (78), which engage guide tracks (42) and (52) that are mounted to the frame.