Abstract: The present invention relates to compressed bone-based products and methods to make the same. The maintained compressed state of the product serves to enhance the product's inherent osteoconductivity.

Abstract: The present invention relates to compressed bone-based products and methods to make the same. The maintained compressed state of the product serves to enhance the product's inherent osteoconductivity.

Abstract: The present invention relates to compressed bone-based products and methods to make the same. The maintained compressed state of the product serves to enhance the product's inherent osteoconductivity.

Abstract: The present invention relates to compressed bone-based products and methods to make the same. The maintained compressed state of the product serves to enhance the product's inherent osteoconductivity.

Abstract: The invention relates to a biocompatible, oxygen scavenging tissue graft for repair and regeneration of tissue injury. The oxygen scavenging tissue graft induces a transient, local hypoxic environment that induces the surrounding tissue to upregulate endogenous pro-angiogenic growth factors to enhance the regenerative capacity of the tissue graft and aid in the healing of the tissue injury once the graft is implanted into a host.

Abstract: The invention relates to a shaped collagen tissue implant comprised of collagen molded in a particular shape and methods of manufacture thereof. The shaped tissue implants of the invention generate tissue structures that retain their size, shape, flexibility, and texture after implantation into a patient.

Abstract: The invention relates to biocompatible implants with enhanced guided nerve axon regeneration and methods of manufacture thereof.

Abstract: This invention relates to a detergent treated biological tissue with low residual detergent and methods of making the same. The low residual detergent is a clinically beneficial aspect of the biological tissue.

Abstract: The present invention relates to an antimicrobial composition, which is a synergistic combination comprising an anti-microbial agent and a polymer or monomer comprising D-alpha hydroxy acid or a polymer capable of releasing a D-alpha hydroxy acid monomer. The present invention also relates to methods for using and applying the same.

Abstract: The present invention is directed to polymeric coating formulations in which addition of an antimicrobial to a solution, containing solvent and polymer, significantly alters polymer entanglements. Benefits include alternative routes to, and customization of the polymer's degradation pathways. The dramatic entanglement changes also provide manufacturing advantages such as ease of stirring, pumping, and spraying. Furthermore, the coatings may have faster drying times, less shrinkage, more complete fill, and a more even coat for a given thickness. Methodology for production of coating formulations of the desired properties and their use to provide antimicrobial coatings is also described.

Abstract: A coating comprised of a polymeric material and a bioactive agent where the properties of the casting solvent dictate the dispersion of the embedding bioactive agent. In preferred embodiments, controlled release of the bioactive agent is achieved by homogeneous dispersion of the bioactive agent within the coating. A further aspect of the invention is directed to formulations where the heterogeneous dispersion of the bioactive agent provides an initial rapid release of the bioactive agent. Methodology for production of coating formulations of the desired properties and the application of the coating to an article are also described.