Abstract: Composition and methods for treating Niemann-Pick disease type C are disclosed, utilizing lipid nanoparticles (LNPs) encapsulating mRNA sequences coding for NPC1 and/or NPC2 proteins.

Abstract: A call routing system and method comprising a branch exchange system designed to receive telephone calls. A session initiation protocol server is operative with the branch exchange system, the session initiation protocol server further having a firewall designed to allow telephone calls to pass therethrough. At least one automated attendant system is designed to request authentication for said telephone calls. At least one computerized telephone device is designed to receive telephone calls and notifications of telephone calls routed through the session initiation protocol server and sent from the branch exchange system. The branch exchange system is designed to route telephone calls based on the validity of the authentication and the presence or absence of a breakthrough number. A voicemail system may be included for message storage and converting audio files to text tiles, increasing, therefore, routing and message delivery options.

Abstract: Systems and methods are provided for receiving a plurality of customized avatars where each customized avatar within the plurality of customized avatars include a first and second image layer. The first image layer includes input of text data overlaid on top of the second image layer, and the second image layer includes a personalized avatar. The system and method further includes receiving a modification of the input of text data from a text interface, generating a third image layer including a representation of text data associated with the modification of the input of text data, removing the first image layer from each of the customized avatars and overlaying the third image layer on top of the second image layer of each of the customized avatars.

Abstract: Systems and methods are provided for receiving a plurality of customized avatars where each customized avatar within the plurality of customized avatars include a first and second image layer. The first image layer includes input of text data overlaid on top of the second image layer, and the second image layer includes a personalized avatar. The system and method further includes receiving a modification of the input of text data from a text interface, generating a third image layer including a representation of text data associated with the modification of the input of text data, removing the first image layer from each of the customized avatars and overlaying the third image layer on top of the second image layer of each of the customized avatars.

Abstract: A user interface is provided for allowing a user to interact with a graphical display. Quantitative data is initially displayed in a graphical format representing absolute values. A comparative graph is also made available, either automatically or in response to user input; the comparative graph presents each data entry according to its relative value as compared with one specific baseline entry.

Abstract: Matching of coefficient of thermal expansion for heat spreaders and carrier die can facilitate optoelectronic die alignment. In one example, an apparatus comprises a carrier die comprising a first coefficient of thermal expansion, two or more optoelectronic die disposed on the carrier die, and a spreader. The spreader can comprise a second material coefficient of thermal expansion matched to the first coefficient of thermal expansion. Additionally, a thermal interface material is disposed between the spreader and the one or more optoelectronic die.

Abstract: A user interface is provided for allowing a user to interact with a graphical display. Quantitative data is initially displayed in a graphical format representing absolute values. A comparative graph is also made available, either automatically or in response to user input; the comparative graph presents each data entry according to its relative value as compared with one specific baseline entry.

Abstract: Matching of coefficient of thermal expansion for heat spreaders and carrier die can facilitate optoelectronic die alignment. In one example, an apparatus comprises a carrier die comprising a first coefficient of thermal expansion, two or more optoelectronic die disposed on the carrier die, and a spreader. The spreader can comprise a second material coefficient of thermal expansion matched to the first coefficient of thermal expansion. Additionally, a thermal interface material is disposed between the spreader and the one or more optoelectronic die.

Abstract: Matching of coefficient of thermal expansion for heat spreaders and carrier die can facilitate optoelectronic die alignment. In one example, an apparatus comprises a carrier die comprising a first coefficient of thermal expansion, two or more optoelectronic die disposed on the carrier die, and a spreader. The spreader can comprise a second material coefficient of thermal expansion matched to the first coefficient of thermal expansion. Additionally, a thermal interface material is disposed between the spreader and the one or more optoelectronic die.

Abstract: A user interface is provided for allowing a user to interact with a graphical display. Quantitative data is initially displayed in a graphical format representing absolute values. A comparative graph is also made available, either automatically or in response to user input; the comparative graph presents each data entry according to its relative value as compared with one specific baseline entry.

Abstract: A method includes determining an average set load corresponding to a plurality of gensets of a power system, generating a power error based on the determined average set load and a set load of a genset of the plurality, generating a first offset based on a function of the power error and a predetermined factor, determining a secondary offset, generating a final offset based on the first offset and the secondary offset, generating a final reference value based on a nominal reference and the final offset, and applying the final reference value to obtain proportional load sharing between the plurality of gensets.

Abstract: Certain embodiments of the present invention provide a method for treating or preventing juvenile neuronal ceroid lipofuscinosis (JNCL) in an animal comprising administering CBX, GRA, or GZA to the animal.

Abstract: A method includes determining an average set load corresponding to a plurality of gensets of a power system, generating a power error based on the determined average set load and a set load of a genset of the plurality, generating a first offset based on a function of the power error and a predetermined factor, determining a secondary offset, generating a final offset based on the first offset and the secondary offset, generating a final reference value based on a nominal reference and the final offset, and applying the final reference value to obtain proportional load sharing between the plurality of gensets.

Abstract: A user interface is provided for allowing a user to interact with a graphical display, so as to facilitate comparative viewing of components of the display. A bar graph or other quantitative display is provided, wherein each bar is divided into a plurality of segments. Responsive to user input, segments of a given kind, in different bars, are realigned with one another along a common baseline, so that their sizes can be more easily compared with one another. In at least one embodiment, the realignment is transitory, and the original graph is restored upon further user input and/or after some predetermined time period.

Abstract: A vehicle with a load sensing hydraulic control system is disclosed.

Abstract: A portable fingerprint development system having a container and a base plate. The container includes a plurality of joined walls that present an opening and a rim surrounding the opening. The base plate has opposed first and second surfaces. The first surface mounts a heater that is operable to heat a fingerprint development material. The base plate is moveable between a transport position, in which the first surface is adjacent the container's rim and the heater is positioned within the container, and an operation position, in which the second surface is adjacent the container's rim to enclose an interior volume defined by the container's walls and the base plate. Preferably, an exhaust system is mounted on the first surface of the base plate for removing and/or filtering fumes within the container.

Abstract: A vehicle with a load sensing hydraulic control system is disclosed.

Abstract: A financial transaction product includes a generally planar structure, which includes a first generally rectangular section and a second generally rectangular section. The first generally rectangular section includes first encoding means for associating the first generally rectangular section with a financial account and first indicia associated with a retail chain. The first generally rectangular section is adapted for use as a stored-value card. The second generally rectangular section includes second encoding means for associating the second generally rectangular section with the same financial account and second indicia associated with the same retail chain as the first indicia. The second generally rectangular section is adapted for use as a stored-value card. A lateral score line separates the first generally rectangular section from the second generally rectangular section with lateral edges of the first and second generally rectangular sections being joined along the lateral score line.

Abstract: A multi-node time division multiplexing (TDM) system is disclosed. The improved method and apparatus utilizes an asynchronous synchronization packet (ASP) to synchronize the timing in all the nodes of the system. In some embodiments, the ASP also maps the time slots in a data frame to particular nodes. The ASP is sent at the start of each data frame to all the nodes in the system and each node synchronizes itself to the time of receipt of the ASP, thus establishing frame-based timing for all the nodes. Additionally, the ASP can contain a table that maps the data frame time slots to the nodes in the system.

Abstract: A method and a system accomplish inspection of a mark in a frame of a film print. The system can include a frame imager which automatically selects at least one frame in the film print having an FMS mark and automatically captures an image of the frame. The image can be captured prior to, or subsequent to, the print being developed. The system also can include a marker which marks the frame with the mark. Further, the system can include a processor which automatically extracts the mark from the captured image and automatically compares the mark on the frame to a reference mark. The captured image can be stored to a database.