Patents by Inventor Mark Sephton

Mark Sephton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition for treatment of pathogens that are resistant to tetracyclines
    Patent number: 9682079
    Abstract: The invention relates to compounds and pharmaceutical compositions useful in combination with tetracyclines in the treatment of bacterial infections caused by Gram-positive and Gram-negative pathogens, with particular efficacy in tetracycline resistant strains. These compounds specifically bind to TetR and therefore prevent the transcriptional activation of tet resistance genes. The compounds have a potentiating effect on the activity of members of the tetracycline family, in particular of tetracycline, minocycline, doxycycline and tigecycline, in the treatment of tetracycline susceptible, intermediate and tetracycline resistant pathogens.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: June 20, 2017
    Assignee: BIOVERSYS AG
    Inventors: Peter Schneider, Rainer Riedl, Marcel Tigges, Marc Gitzinger, Michel Pieren, Assaf Levi, Mark Sephton, Birgit Schellhorn, Patrik Zueger, Michael Brand, Daniel Gygax, Peter Spies
  • COMPOSITION FOR TREATMENT OF PATHOGENS THAT ARE RESISTANT TO TETRACYCLINES
    Publication number: 20150359791
    Abstract: The invention relates to compounds and pharmaceutical compositions useful in combination with tetracyclines in the treatment of bacterial infections caused by Gram-positive and Gram-negative pathogens, with particular efficacy in tetracycline resistant strains. These compounds specifically bind to TetR and therefore prevent the transcriptional activation of tet resistance genes. The compounds have a potentiating effect on the activity of members of the tetracycline family, in particular of tetracycline, minocycline, doxycycline and tigecycline, in the treatment of tetracycline susceptible, intermediate and tetracycline resistant pathogens.
    Type: Application
    Filed: February 3, 2014
    Publication date: December 17, 2015
    Inventors: Peter Schneider, Rainer Riedl, Marcel Tigges, Marc Gitzinger, Michel Pieren, Assaf Levi, Mark Sephton, Birgit Schellhorn, Patrik Zueger, Michael Brand, Daniel Gygax, Peter Spies
  • AQUEOUS SOLVENTS FOR HYDROCARBONS AND OTHER HYDROPHOBIC COMPOUNDS
    Publication number: 20120132594
    Abstract: A method of solubilising in an aqueous medium a hydrocarbon or a hydrophobic compound having a hydrocarbon skeleton that carries one or more heteroatom-containing functional groups, e.g. hydroxyl, carboxylic acid or aldehyde (CHO) groups. The method comprises contacting the hydrocarbon or the hydrophobic compound with the aqueous medium that includes at least one non-ionic surfactant containing a hydrophilic part and a hydrophobic part, the hydrophilic part comprising a polyhydroxylated moiety and the hydrophobic part comprising a hydrocarbon chain containing at least 12 carbon atoms, e.g. ethoxylated sorbitol. The amount of surfactant used is sufficient to form micelles including a core formed of the hydrocarbon or the hydrophobic compound.
    Type: Application
    Filed: April 20, 2010
    Publication date: May 31, 2012
    Applicant: IMPERIAL INNOVATIONS LIMITED
    Inventors: Alexander O. Baki, Mark A. Sephton, Mark R. Sims, David C. Cullen