Abstract: The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.

Abstract: The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.

Abstract: An implantable sensor device includes a sensor-support substrate, a microelectromechanical systems (MEMS) pressure sensor device mounted to the sensor-support substrate, a transduction medium applied over the pressure sensor device, and a biocompatibility layer applied over the transduction medium

Abstract: A steerable micro-endoscope comprising a cylindrical elongated member having at least a first lumen, a tensioning wire running in the first lumen and attached at the distal end of the elongated member; the elongated member having a proximal portion and a distal portion, having respectively a first durometer and a second durometer lower than the first durometer; the first lumen being arranged such that the distal portion of the elongated body bends when the tensioning wire is pulled; wherein the elongated member comprises a second lumen; an electrode wire being arranged in the second lumen such that the distal end of the electrode wire does not protrude from the distal portion of the elongated member when the elongated member is not bent, and such that the distal end of the electrode wire protrudes from the distal portion of the elongated member when the elongated member is bent.

Abstract: The invention generally relates to an electric vehicle having an electric motor and a pack for storing energy, said vehicle configured having: at least two passenger seats, including a first seat, and a second seat, positioned behind the front seat and configured to face rearward; and the pack having: a lateral module configured to extend perpendicularly to the longitudinal axis of the vehicle between the first seat and the second seat.

Abstract: An apparatus and method for irradiating a fluid containing a material to be irradiated, comprising at least one irradiation chamber having at least one inlet port and outlet port, at least one fluid cooling chamber having at least one inlet port and outlet port, one or more UV radiation sources coupled to the irradiation chamber(s); and at least one heat exchange mechanism thermally coupled to the radiation source(s) and the cooling chamber(s). At least a portion of the interior surface of the cooling chamber(s) may comprise at least a portion of the exterior surface of the irradiation chamber(s) so the cooling chamber(s) is in fluid communication with the irradiation chamber(s).

Abstract: An apparatus and method for irradiating a fluid containing a material to be irradiated, comprising at least one irradiation chamber having at least one inlet port, one or more UV radiation sources inside the irradiation chamber(s) optically coupled to the fluid in the irradiation chamber(s) via at least one UV-transparent window in contact with the fluid; one or more seals or gaskets disposed adjacent to the radiation sources to protect them from the fluid; and at least one heat exchange mechanism inside the irradiation chamber(s) thermally coupled to the radiation sources and to the fluid. The UV radiation sources and the at least one heat exchange mechanism are at least partially submerged in the fluid in the irradiation chamber.

Abstract: The present disclosure provides host cells, e.g., bacterial cells, that comprise a methionine decarboxylase enzyme for the treatment of diseases and disorders associated with methionine metabolism in a subject. The disclosure further provides pharmaceutical compositions and methods of treating disorders associated with methionine metabolism, such as homocystinuria.

Abstract: A valve piston has a central axis along which mutually spaced control geometries are provided, which are bypassed by a passage that extends through the valve piston. The valve piston is, at least in portions, manufactured additively. A valve is includes a valve housing and a housing recess, in which the valve piston is received so that it is adjustable relative to the valve housing.

Abstract: Provided are roofing granules, such as algaecidal roofing granules, methods for making them and their use in roofing products. In one aspect, the disclosure provides an algaecidal roofing granule that comprises an ion-exchanged zeolite disposed within the binder, wherein the ion-exchanged zeolite comprises algaecidal ions.

Abstract: Apparatus (50) for fitting to an end of an internal wall, said apparatus (50) including a web portion (52) and a pair of legs (61, 63) extending from the web portion (52) in the same direction; at least one of the legs (61) in said pair of legs (61, 63) having a recess (56) that extends into a space formed by the web portion (52) and each of said legs (61, 63) such that a shadow line is created by the recess (56) near to the wall end in the overall finish of said wall.

Abstract: A method of managing an online support group to increase the odds that users will attain their wellness goals is disclosed. A request from a user to join a support group is received. A preference of the user with respect to a type of the support group is received. The support group is selected from a plurality of support groups based on the preference of the user and a preference of a member of the support group. Based on an acceptance by the user of an option to join the support group, the plurality of support groups is reorganized.

Abstract: An apparatus and method for irradiating a fluid containing a material to be irradiated, comprising at least one irradiation chamber having at least one inlet port and outlet port, at least one fluid cooling chamber having at least one inlet port and outlet port, one or more UV radiation sources coupled to the irradiation chamber(s); and at least one heat exchange mechanism thermally coupled to the radiation source(s) and the cooling chamber(s). At least a portion of the interior surface of the cooling chamber(s) may comprise at least a portion of the exterior surface of the irradiation chamber(s) so the cooling chamber(s) is in fluid communication with the irradiation chamber(s).

Abstract: An apparatus and method for irradiating a fluid containing a material to be irradiated, comprising at least one irradiation chamber having at least one inlet port and outlet port, at least one fluid cooling chamber having at least one inlet port and outlet port, one or more UV radiation sources coupled to the irradiation chamber(s); and at least one heat exchange mechanism thermally coupled to the radiation source(s) and the cooling chamber(s). At least a portion of the interior surface of the cooling chamber(s) may comprise at least a portion of the exterior surface of the irradiation chamber(s) so the cooling chamber(s) is in fluid communication with the irradiation chamber(s).

Abstract: This invention relates to methods and compositions for treating Angelman syndrome, including administering to a subject an effective amount of a clustered regularly interspersed short palindromic repeat (CRISPR)-associated endonuclease and one or more than one guide RNA molecules having complementarity to a target nucleotide sequence in UBE3A-ATS in cells of the subject.

Abstract: A valve piston has a central axis along which mutually spaced control geometries are provided, which are bypassed by a passage that extends through the valve piston. The valve piston is, at least in portions, manufactured additively. A valve is includes a valve housing and a housing recess, in which the valve piston is received so that it is adjustable relative to the valve housing.

Abstract: An apparatus and method for irradiating a fluid containing a material to be irradiated, comprising at least one irradiation chamber having at least one inlet port and outlet port, at least one fluid cooling chamber having at least one inlet port and outlet port, one or more UV radiation sources coupled to the irradiation chamber(s); and at least one heat exchange mechanism thermally coupled to the radiation source(s) and the cooling chamber(s). At least a portion of the interior surface of the cooling chamber(s) may comprise at least a portion of the exterior surface of the irradiation chamber(s) so the cooling chamber(s) is in fluid communication with the irradiation chamber(s).

Abstract: A portable electronic lock for luggage, comprising: a housing and a securement member in cooperation with the housing to secure an item to the lock; a locking mechanism in the housing in communication with the securement member to releasably secure the securement member to the housing; a communications module in the housing for operating the locking mechanism to release and secure the securement member in response to a wireless signal; and a secondary release system for releasing the locking mechanism, wherein the secondary release system is selectively operable by a user.

Abstract: An apparatus and method for irradiating a fluid containing a material to be irradiated, comprising at least one irradiation chamber having at least one inlet port and outlet port, at least one fluid cooling chamber having at least one inlet port and outlet port, one or more UV radiation sources coupled to the irradiation chamber(s); and at least one heat exchange mechanism thermally coupled to the radiation source(s) and the cooling chamber(s). At least a portion of the interior surface of the cooling chamber(s) may comprise at least a portion of the exterior surface of the irradiation chamber(s) so the cooling chamber(s) is in fluid communication with the irradiation chamber(s).