Patents by Inventor Mark Spaller

Mark Spaller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vista antagonist and methods of use
    Patent number: 11752189
    Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
    Type: Grant
    Filed: October 31, 2019
    Date of Patent: September 12, 2023
    Assignees: THE TRUSTEES OF DARTMOUTH COLLEGE, KING'S COLLEGE LONDON
    Inventors: Randolph J. Noelle, Sabrina Ceeraz, Isabelle LeMercier, Elizabeth Nowak, Janet Lines, Li Wang, Mark Spaller
  • VISTA ANTAGONIST AND METHODS OF USE
    Publication number: 20210361736
    Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
    Type: Application
    Filed: February 26, 2021
    Publication date: November 25, 2021
    Inventors: Randolph J. NOELLE, Sabrina CEERAZ, Isabelle LEMERCIER, Elizabeth NOWAK, Janet LINES, Li WANG, Mark SPALLER
  • VISTA antagonist and methods of use
    Patent number: 10933115
    Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: March 2, 2021
    Assignees: THE TRUSTEES OF DARTMOUTH COLLEGE, KING'S GOLLEGE LONDON
    Inventors: Randolph J. Noelle, Sabrina Ceeraz, Isabelle Lemercier, Elizabeth Nowak, Janet Lines, Li Wang, Mark Spaller
  • VISTA ANTAGONIST AND METHODS OF USE
    Publication number: 20200093902
    Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
    Type: Application
    Filed: October 31, 2019
    Publication date: March 26, 2020
    Inventors: Randolph J. NOELLE, Sabrina CEERAZ, Isabelle LeMERCIER, Elizabeth NOWAK, Janet LINES, Li WANG, Mark SPALLER
  • Cyclic-GluR6 analogs, methods of treatment and use
    Patent number: 10046024
    Abstract: A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising wherein R is a molecular transporter with or without a linker amino acid; R1 is at least about one amino acid covalently bound; and, R2 is isoleucine, leucine, alanine, phenylalanine, or valine, and methods of use.
    Type: Grant
    Filed: June 28, 2016
    Date of Patent: August 14, 2018
    Assignee: The United States of America, as represented by National Institutes of Health (NIH), U.S. Dept of Health and Human Services (DHHS), NIH Division of Extramural Inventions and Technology Resource (DEITR)
    Inventors: Mark Spaller, John Marshall, Dennis J. Goebel
  • VISTA ANTAGONIST AND METHODS OF USE
    Publication number: 20160331803
    Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
    Type: Application
    Filed: January 23, 2015
    Publication date: November 17, 2016
    Inventors: Randolph J. NOELLE, Sabrina CEERAZ, Isabelle LEMERCIER, Elizabeth NOWAK, Janet LINES, Li WANG, Mark SPALLER
  • CYCLIC-GLUR6 ANALOGS, METHODS OF TREATMENT AND USE
    Publication number: 20160303186
    Abstract: A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising wherein R is a molecular transporter with or without a linker amino acid; R1 is at least about one amino acid covalently bound; and, R2 is isoleucine, leucine, alanine, phenylalanine, or valine, and methods of use.
    Type: Application
    Filed: June 28, 2016
    Publication date: October 20, 2016
    Inventors: Mark Spaller, John Marshall, Dennis J. Goebel
  • Cyclic-GluR6 analogs, methods of treatment and use
    Patent number: 9403876
    Abstract: A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising wherein R is a molecular transporter with or without a linker amino acid; R1 is at least about one amino acid covalently bound; and, R2 is isoleucine, leucine, alanine, phenylalanine, or valine, and methods of use.
    Type: Grant
    Filed: May 18, 2010
    Date of Patent: August 2, 2016
    Assignee: Brown University
    Inventors: Mark Spaller, John Marshall, Dennis J. Goebel
  • Peptides and nanoparticles for therapeutic and diagnostic applications
    Patent number: 9163063
    Abstract: Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: October 20, 2015
    Assignees: Trustees of Darmouth College, Mayo Foundation for Medical Education and Research
    Inventors: Debabrata Mukhopadhyay, Priyabrata Mukherjee, Mark Spaller
  • VISTA Antagonist and Methods of Use
    Publication number: 20150231215
    Abstract: The present invention is directed to a peptide, multimer, conjugate, analog, derivative or mimetic thereof that inhibits the activity of VISTA. The invention further contemplates therapeutic use of the VISTA antagonist peptide, multimer, conjugate, derivative or mimetic thereof, including treating or preventing cancer, bacterial infections, viral infections, parasitic infections and fungal infections, as well as research uses of the antagonist.
    Type: Application
    Filed: November 6, 2014
    Publication date: August 20, 2015
    Inventors: Randolph J. NOELLE, Sabrina CEERAZ, Isabelle LeMERCIER, Elizabeth NOWAK, Janet LINES, Li WANG, Mark SPALLER
  • PEPTIDES AND NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
    Publication number: 20140329760
    Abstract: Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
    Type: Application
    Filed: October 23, 2013
    Publication date: November 6, 2014
    Applicants: Mayo Foundation for Medical Education and Research, Trustees of Dartmouth College
    Inventors: Debabrata Mukhopadhyay, Priyabrata Mukherjee, Mark Spaller
  • Peptides and nanoparticles for therapeutic and diagnostic applications
    Patent number: 8658601
    Abstract: Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
    Type: Grant
    Filed: August 1, 2011
    Date of Patent: February 25, 2014
    Assignees: Trustees of Dartmouth College, Mayo Foundation for Medical Education and Research
    Inventors: Debabrata Mukhopadhyay, Priyabrata Mukherjee, Mark Spaller
  • CYCLIC-GLUR6 ANALOGS, METHODS OF TREATMENT AND USE
    Publication number: 20120220535
    Abstract: A composition which is reversible inhibitor of at least one neuron-specific PDZ domain comprising wherein R is a molecular transporter with or without a linker amino acid; R1 is at least about one amino acid covalently bound; and, R2 is isoleucine, leucine, alanine, phenylalanine, or valine, and methods of use.
    Type: Application
    Filed: May 18, 2010
    Publication date: August 30, 2012
    Inventors: Mark Spaller, John Marshall, Dennis J. Goebel
  • PEPTIDES AND NANOPARTICLES FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS
    Publication number: 20120040915
    Abstract: Provided herein are peptides and nanoparticles conjugates thereof useful for the treatment of diseases and disorders mediated by GIPC/synectin, such as cancer.
    Type: Application
    Filed: August 1, 2011
    Publication date: February 16, 2012
    Inventors: Debabrata Mukhopadhyay, Priyabrata Mukherjee, Mark Spaller