Patents by Inventor Mark Sparacino

Mark Sparacino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
    Patent number: 7649015
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: January 19, 2010
    Assignee: Gilead Sciences, Inc.
    Inventors: Murty N. Arimili, Xiaowu Chen, Maria Fardis, Gong-Xin He, Haolun Jin, Choung U. Kim, William A. Lee, Kuei-Ying Lin, Hongtao Liu, Richard L. Mackman, Michael L. Mitchell, Hyung-Jung Pyun, Mark Sparacino, Sundaramoorthi Swaminathan, Jianying Wang, Matthew A. Williams, Lianhong Xu, Zheng-Yu Yang, Richard H. Yu, Jiancun Zhang, Lijun Zhang
  • Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
    Publication number: 20070010489
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Application
    Filed: April 25, 2003
    Publication date: January 11, 2007
    Inventors: Murty Arimilli, Mark Becker, Clifford Bryant, James Chen, Xiaowu Chen, Azar Dastgah, Maria Fardis, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard Mackman, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Wiliams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
    Publication number: 20060024659
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: February 24, 2004
    Publication date: February 2, 2006
    Inventors: Mark Becker, Harlan Chapman, Tomas Cihlar, Eugene Eisenberg, Gong-Xin He, Michael Kernan, William Lee, Ernest Prisbe, John Rohloff, Mark Sparacino
  • Method and compositions for identifying anti-HIV therapeutic compounds
    Publication number: 20050239054
    Abstract: Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.
    Type: Application
    Filed: December 22, 2003
    Publication date: October 27, 2005
    Inventors: Murty Arimilli, Mark Becker, Gabriel Birkus, Clifford Bryant, James Chen, Xiaowu Chen, Tomas Cihlar, Azar Dastgah, Eugene Eisenberg, Maria Fardis, Marcos Hatada, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard MacKman, Martin McDermott, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Williams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
    Publication number: 20050209197
    Abstract: Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.
    Type: Application
    Filed: April 25, 2003
    Publication date: September 22, 2005
    Inventors: Murty Arimilli, Mark Becker, Clifford Bryant, James Chen, Xiaowu Chen, Azar Dastgah, Maria Fardis, Gong-Xin He, Haolun Jin, Choung Kim, William Lee, Christopher Lee, Kuei-Ying Lin, Hongtao Liu, Richard Mackman, Michael Mitchell, Peter Nelson, Hyung-Jung Pyun, Tanisha Rowe, Mark Sparacino, Sundaramoorthi Swaminathan, James Tario, Jianying Wang, Matthew Williams, Lianhong Xu, Zheng-Yu Yang, Richard Yu, Jiancun Zhang, Lijun Zhang
  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20050159392
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: January 6, 2005
    Publication date: July 21, 2005
    Inventors: Mark Becker, Harlan Chapman, Tomas Cihlar, Eugene Eisenberg, Gong-Xin He, Michael Kernan, William Lee, Ernest Prisbe, John Rohloff, Mark Sparacino
  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20050124585
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: January 6, 2005
    Publication date: June 9, 2005
    Inventors: Mark Becker, Harlan Chapman, Tomas Cihlar, Eugene Eisenberg, Gong-Xin He, Michael Kernan, William Lee, Ernest Prisbe, John Rohloff, Mark Sparacino
  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20050124584
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: January 6, 2005
    Publication date: June 9, 2005
    Inventors: Mark Becker, Harlan Chapman, Tomas Cihlar, Eugene Eisenberg, Gong-Xin He, Michael Kernan, William Lee, Ernest Prisbe, John Rohloff, Mark Sparacino
  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20050124583
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: January 6, 2005
    Publication date: June 9, 2005
    Inventors: Mark Becker, Harlan Chapman, Tomas Clhlar, Eugene Elsenberg, Gong-Xin He, Michael Kernan, William Lee, Ernest Prisbe, John Rohloff, Mark Sparacino
  • Prodrugs of phosphonate nucleotide analogues
    Publication number: 20050009043
    Abstract: A novel method has led to the identification of novel mixed ester-amidates of PMPA for retroviral or hepadnaviral therapy, including compounds of structure (5a) having substituent groups as defined herein. Compositions of these novel compounds in pharmaceutically acceptable excipients and their use in therapy and prophylaxis are provided.
    Type: Application
    Filed: March 11, 2004
    Publication date: January 13, 2005
    Inventors: Mark Becker, Harlan Chapman, Tomas Cihlar, Eugene Eisenberg, Gong-Xin He, Michael Kernan, William Lee, Ernest Prisbe, John Rohloff, Mark Sparacino