Patents by Inventor Mark Spilker
Mark Spilker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230389911Abstract: The invention provides an applicator of a spongeous collagen membrane and a kit comprising such applicator and such membrane. The applicator comprises an applicator body having a guide extending in a direction from the proximal end to the distal end of the applicator body and a sliding element slidably comprising a shaft portion movable along the guide. The sliding element is provided at its distal end with a contact portion for contacting the spongeous collagen membrane, and the contact portion of the sliding element comprises mechanical fixation means configured to releasably hold the spongeous collagen membrane without substantially generating forces acting in the distal direction on the spongeous collagen membrane over its area extension. The distal end of the applicator body comprises a release surface configured to apply a release force to the spongeous collagen membrane releasing it from the mechanical fixation means for application to the wound site.Type: ApplicationFiled: October 14, 2021Publication date: December 7, 2023Applicant: GEISTLICH PHARMA AGInventors: Michael TRITTO, Niklaus STIEFEL, Raphael KAUFMANN, Mark SPILKER
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Patent number: 11786637Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: March 1, 2021Date of Patent: October 17, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 11697148Abstract: A tool for installing fasteners comprising a hydraulically powered tool with a tool body and handle, trigger for actuating the tool, piston, and a nose assembly comprising anvil assembly, puller, a spring inside a shock tube and collet assembly, and a free-floating ejector, wherein severed fastener pintails move backward through the spring to the rear of the tool. The anvil is in threaded connection to the anvil assembly and may be removed for cleaning and to access the free-floating ejector.Type: GrantFiled: February 20, 2022Date of Patent: July 11, 2023Inventor: Mark Spilker
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Patent number: 11596517Abstract: Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.Type: GrantFiled: October 10, 2019Date of Patent: March 7, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Michele McAllister, David Wang, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Patent number: 11571494Abstract: A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.Type: GrantFiled: December 16, 2020Date of Patent: February 7, 2023Assignees: Geistlich Pharma AG, University of Southern CaliforniaInventors: Charles Zelen, David G. Armstrong, Paul Glat, Jarrod Kaufman, Marco Mehr, Lothar Schloesser, Mark Spilker
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Publication number: 20230030907Abstract: Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.Type: ApplicationFiled: October 14, 2022Publication date: February 2, 2023Inventors: Michele Christine McAllister, David Wang, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Patent number: 11292050Abstract: A hydraulic fastener tool comprising with a piston in threaded connection with a single-unit puller that is inside a single-unit anvil. Inside the puller is a segmented collet assembly with an internal spring and guide tube. In use, the tool secures fasteners and ejects the severed fastener stem after fastening.Type: GrantFiled: February 7, 2020Date of Patent: April 5, 2022Inventor: Mark Spilker
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Publication number: 20220023498Abstract: A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.Type: ApplicationFiled: December 16, 2020Publication date: January 27, 2022Applicants: Geistlich Pharma AG, University of Southern CaliforniaInventors: Charles ZELEN, David G. ARMSTRONG, Paul GLAT, Jarrod KAUFMAN, Marco MEHR, Lothar SCHLOESSER, Mark SPILKER
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Publication number: 20210178022Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: ApplicationFiled: March 1, 2021Publication date: June 17, 2021Inventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 10973953Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: August 17, 2017Date of Patent: April 13, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 10869949Abstract: A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.Type: GrantFiled: April 10, 2020Date of Patent: December 22, 2020Assignees: Geistlich Pharma AG, University of Southern CaliforniaInventors: Charles Zelen, David Armstrong, Paul Glat, Jarrod Kaufman, Marco Mehr, Lothar Schloesser, Mark Spilker
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Publication number: 20200324020Abstract: A method, material, and kit for promoting neutrophils and monocytes to localize at a chronic ulcer site, promoting formation of a multi-layered cell structure in the ulcer site, promoting conversion of monocytes to macrophages, promoting secretion of the patient's own growth factors, promoting tissue proliferation and cell migration, promoting production and cross-linking of collagen at the chronic ulcer site, promoting growth of endothelial cells, promoting angiogenesis that was stalled at the chronic ulcer site, promoting formation of a vascular network and granulation, promoting oxygenation of the chronic ulcer site, and reducing one or more of purulent drainage, erythema, pain, warming, tenderness, induration, and bleeding at the chronic ulcer site.Type: ApplicationFiled: April 10, 2020Publication date: October 15, 2020Applicants: Geistlich Pharma AG, University of Southern CaliforniaInventors: Charles ZELEN, David ARMSTRONG, Paul GLAT, Jarrod KAUFMAN, Marco MEHR, Lothar SCHLOESSER, Mark SPILKER
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Publication number: 20200046501Abstract: Methods for making surgical implants (or grafts) for the repair of bone defects, and more particularly, surgical implants that include demineralized bone fibers, are disclosed. Also disclosed are methods for increasing the wettability and ensuring uniform density of such implants. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration.Type: ApplicationFiled: October 10, 2019Publication date: February 13, 2020Inventors: Michele McAllister, David Wang, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Patent number: 10531957Abstract: Surgical implants (or grafts) for the repair of bone defects, more particularly, surgical implants that include demineralized bone fibers, are disclosed. The surgical implants have a wettability time of less than 5 minutes and a residual moisture content of less than 6% by weight, and they remain cohesive and retain their shape upon complete rehydration. Methods for making such implants and for increasing their wettability and ensuring uniform density are also disclosed.Type: GrantFiled: May 19, 2016Date of Patent: January 14, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Michele McAllister, David Wang, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Publication number: 20160361171Abstract: Surgical grafts for the repair of bone defects, more particularly, surgical grafts that include demineralized bone fibers, are disclosed. Methods for making such grafts and for increasing their wettability and ensuring uniform density are also disclosed.Type: ApplicationFiled: May 19, 2016Publication date: December 15, 2016Applicant: MUSCULOSKELETAL TRANSPLANT FOUNDATIONInventors: David Wang, Michele McAllister, Michelle Bubear, Joed Canales, Amy Chang, Roman Shikhanovich, Mark Spilker, Eric Semler
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Patent number: 8846060Abstract: A matrix for tissue growth includes: (a) a first layer including a first assembly of collagen fibers; (b) a plurality of projections on a top surface of the first layer; and (c) a second layer bonded to a bottom portion of the first layer and including a second assembly of collagen fibers, wherein the second layer has a lower density than the first layer, and the matrix includes pores effective to support cell growth into the matrix. A method for providing the matrix is also described.Type: GrantFiled: January 12, 2007Date of Patent: September 30, 2014Assignee: Integra LifeSciences CorporationInventors: Simon J. Archibald, Mark Spilker, Ronald T. Ingram, Jeffrey M. Brittan
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Publication number: 20110123299Abstract: Methods and devices for positioning a group, array, series or arrangement of plumb poles in a specific relationship relative to each other, whereby a first pole is inserted in a horizontal clamshell attached to a moveable platform, retained and raised to a vertical position and plumbed. The moveable platform is positioned over the pole insertion location and the pole is released. The process is repeated at as many holes as needed. Other embodiments are used to set the poles at specific heights, or angles.Type: ApplicationFiled: January 27, 2011Publication date: May 26, 2011Inventor: Mark Spilker
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Patent number: 7901173Abstract: Methods and devices for positioning a group, array, series or arrangement of plumb poles in a specific relationship relative to each other, whereby a first pole is inserted in a horizontal clamshell attached to a moveable platform, retained and raised to a vertical position and plumbed. The moveable platform is positioned over the pole insertion location and the pole is released. The process is repeated at as many holes as needed. Other embodiments are used to set the poles at specific heights, or angles.Type: GrantFiled: April 24, 2008Date of Patent: March 8, 2011Assignee: Solar Foundation Solutions, Inc.Inventor: Mark Spilker
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Publication number: 20100016967Abstract: Biocompatible, resorbable medical implants and related methods are disclosed in which the implant can be made of a collagen matrix for filling a space after partial or total resection of the trapezium bone of the wrist. The resorbable medical implant can include a plurality of surface projections, and the collagen matrix can be folded or spirally wound about itself to form a spiral roll.Type: ApplicationFiled: July 10, 2009Publication date: January 21, 2010Inventors: Arnold-Peter C. Weiss, Jignesh B. Patel, Karishma Vohra, Namrata Desai, Ronald T. Ingram, Mark Spilker, Timothy J. Pryor, Heather Beam-Brennan
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Publication number: 20080267739Abstract: Methods and devices for positioning a group, array, series or arrangement of plumb poles in a specific relationship relative to each other, whereby a first pole is inserted in a horizontal clamshell attached to a moveable platform, retained and raised to a vertical position and plumbed. The moveable platform is positioned over the pole insertion location and the pole is released. The process is repeated at as many holes as needed. Other embodiments are used to set the poles at specific heights, or angles.Type: ApplicationFiled: April 24, 2008Publication date: October 30, 2008Inventor: Mark Spilker