Abstract: In one aspect, a method is provided herein of preparing a drug delivery device, the drug delivery device having a body with at least one fluid duct being open along a first face of the body, the at least one fluid duct for conveying drug from at least one reservoir to a needle configured for injection into a patient, the method including: providing a barrier across the first face of the body to at least cover the at least one fluid duct, wherein the barrier is ultraviolet transmissive; and, exposing the first face of the body to ultraviolet radiation so as to allow the ultraviolet radiation to pass through the barrier and decontaminate the at least one fluid duct.

Abstract: In one aspect of the present invention, a drug delivery device is provided for delivering drug from a plurality of drug cartridges to a patient, wherein, in an initial state, each of the drug cartridges includes at least one drug contained in the body between a stopper and a septum thereof. The drug delivery device includes: a cylindrical cassette configured to accommodate the plurality of drug cartridges; a reversibly advanceable plunger; a first shaft having a cross element mounted thereto, the first shaft coupled to the cassette so that rotation of the cross element results in corresponding rotation of the cassette to align the plurality of drug cartridges individually with the plunger, the plunger being advanceable to urge the stopper of the aligned drug cartridge towards the septum of the aligned drug cartridge. Advantageously, the subject invention provides an arrangement for reversibly adjusting the drug cartridges in various fixed increments.

Abstract: A peristaltic pump is provided herein including: a rotatable drive plate; a closed-loop channel; a fluid inlet located at a first location along the channel; a fluid outlet located at a second location along the channel, spaced from the first location, wherein a first portion of the channel extends between the fluid inlet and the fluid outlet, and a second portion of the channel, separate from the first portion of the channel, extends between the fluid outlet and the fluid inlet; a flexible membrane extending between, and fluidically connecting, the fluid inlet and the fluid outlet, the flexible membrane defining a closed fluid path between the fluid inlet and the fluid outlet along the first portion of the channel; and, a first roller captively disposed between the channel and the drive plate such that rotation of the drive plate causes the first roller to traverse the channel, the first roller causing downward deflection of the flexible membrane in passing therealong to constrict the closed fluid path in di

Abstract: A valving arrangement is provided herein for regulating fluidics of modules useable in a combinatorial drug delivery device. The valving includes a slidable piston valve, adjustable to selectively seal an outlet path from a drug vial and a sealing port, in parallel to a vent, for selectively sealing an inlet path to the drug vial. Advantageously, the subject invention allows for applied negative pressure to adjust the valving to allow flow between serially-connected modules forming a drug delivery device.

Abstract: A valving arrangement is provided herein for regulating fluidics of modules usable in a combinatorial drug delivery device. The valving includes a slidable piston valve, adjustable to selectively seal an outlet path from a drug vial and a sealing port, in parallel to a vent, for selectively sealing an inlet path to the drug vial. Advantageously, the subject invention allows for applied negative pressure to adjust the valving to allow flow between serially-connected modules forming a drug delivery device.

Abstract: A combinatorial drug delivery device is provided for delivering a predetermined selection of drug components, each of the drug components being contained in a drug vial. The device includes a plurality of modules, wherein each of the modules includes: a body having an interior volume formed to accommodate a drug vial; a cannula protruding into the interior volume, the cannula terminating at a free end, first and second openings being formed in the free end with first and second lumens extending therefrom and through the cannula; a socket located on an exterior portion of the body; a first passageway extending between, and in communication with, the socket and the first lumen; a boss protruding from an exterior portion of the body; and, a second passageway extending from, and in communication with the second lumen, the second passageway extending through the boss to terminate at an exit opening formed therein.

Abstract: In one aspect, a drug delivery device is provided herein including: a monolithic body having a plurality of fluid ducts and at least one outlet duct formed therein; a plurality of drug cartridges attached to the body, the drug cartridges each including a reservoir for accommodating at least one drug wherein, the plurality of fluid ducts is arranged to convey the drugs from the drug cartridges to the at least one outlet duct; and, a needle support spaced from the body, the needle support including a needle configured for insertion into a patient for drug delivery, the needle support including adhesive for releasable securement to a patient, wherein, the needle support is connected to the body by a flexible tether through which passes at least one fluid passageway formed to convey drug from the at least one outlet duct to the needle.

Abstract: A combinatorial drug delivery device is provided for delivering a predetermined selection of drug components, each of the drug components being contained in a drug vial. The device includes a plurality of modules, wherein each of the modules includes: a body having an interior volume formed to accommodate a drug vial; a cannula protruding into the interior volume, the cannula terminating at a free end, first and second openings being formed in the free end with first and second lumens extending therefrom and through the cannula; a socket located on an exterior portion of the body; a first passageway extending between, and in communication with, the socket and the first lumen; a boss protruding from an exterior portion of the body; and, a second passageway extending from, and in communication with the second lumen, the second passageway extending through the boss to terminate at an exit opening formed therein.

Abstract: In one aspect, a method is provided herein of preparing a drug delivery device, the drug delivery device having a body with at least one fluid duct being open along a first face of the body, the at least one fluid duct for conveying drug from at least one reservoir to a needle configured for injection into a patient, the method including: providing a barrier across the first face of the body to at least cover the at least one fluid duct, wherein the barrier is ultraviolet transmissive; and, exposing the first face of the body to ultraviolet radiation so as to allow the ultraviolet radiation to pass through the barrier and decontaminate the at least one fluid duct.

Abstract: In one aspect, a drug delivery device is provided for delivering drug from a plurality of drug cartridges. The drug delivery device includes: a cylindrical cassette configured to accommodate the plurality of drug cartridges; a reversibly advanceable plunger; and, an indexer for incrementally rotating the cassette to align the plurality of drug cartridges individually with the plunger. The indexer includes first and second shafts with cooperating elements which cause incremental rotation of the first shaft, relative to the second shaft, upon the second shaft engaging the first shaft.

Abstract: Various embodiments are disclosed herein related to fluidic connections for modules useable in combinatorial drug delivery devices. The fluidic connections allow for variable flow paths to be defined for serially-connected, and base-tray mounted, modules.

Abstract: A valving arrangement is provided herein for regulating fluidics of modules usable in a combinatorial drug delivery device. The valving includes a slidable piston valve, adjustable to selectively seal an outlet path from a drug vial and a sealing port, in parallel to a vent, for selectively sealing an inlet path to the drug vial. Advantageously, the subject invention allows for applied negative pressure to adjust the valving to allow flow between serially-connected modules forming a drug delivery device.

Abstract: A combinatorial drug delivery device is provided for delivering a predetermined selection of drug components, each of the drug components being contained in a drug vial. The device includes a plurality of modules, wherein each of the modules includes: a body having an interior volume formed to accommodate a drug vial; a cannula protruding into the interior volume, the cannula terminating at a free end, first and second openings being formed in the free end with first and second lumens extending therefrom and through the cannula; a socket located on an exterior portion of the body; a first passageway extending between, and in communication with, the socket and the first lumen; a boss protruding from an exterior portion of the body; and, a second passageway extending from, and in communication with the second lumen, the second passageway extending through the boss to terminate at an exit opening formed therein.