Patents by Inventor Mark Steven Oberste

Mark Steven Oberste has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell lines for virus production and methods of use
    Patent number: 10137188
    Abstract: Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picornavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: November 27, 2018
    Assignees: University of Georgia Research Foundation, Inc., The United States of America, as represented by the Secretary, Dept. of Health and Human Services, Thermo Fisher Scientific, Inc.
    Inventors: Jon Michael Karpilow, Mark Steven Oberste, Ralph A. Tripp, Stephen M. Tompkins
  • CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE
    Publication number: 20170151322
    Abstract: Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
    Type: Application
    Filed: February 5, 2014
    Publication date: June 1, 2017
    Inventors: Jon Michael Karpilow, Mark Steven Oberste, Ralph A. Tripp, Stephen M. Tompkins
  • CELL LINES FOR VIRUS PRODUCTION AND METHODS OF USE
    Publication number: 20150374812
    Abstract: Provided herein are engineered cell lines. In some embodiments, cells of an engineered cell line have altered expression of a gene and/or altered expression of an miRNA, wherein the altered expression results in increased or decreased production of a virus. The virus is a picomavirus, such as a poliovirus or Enterovirus 71. Also provided herein are methods for using the engineered cells to produce virus, and methods for treating a subject having or at risk of having a viral infection.
    Type: Application
    Filed: February 5, 2014
    Publication date: December 31, 2015
    Inventors: Jon Michael Karpilow, Mark Steven Oberste, Ralph A. Tripp, Stephen M. Tompkins
  • Live attenuated virus vaccines for western equine encephalitis virus, eastern equine encephalitis virus, and venezuelan equine encephalitis virus IE and IIIA variants
    Patent number: 6261570
    Abstract: cDNAs coding for an infectious Western Equine Encephalitis virus (WEE) and infectious Venezuelan Equine Encephalitis virus variant IE (VEE IE) are disclosed in addition to cDNA coding for the structural proteins of Venezuelan Equine Encephalitis virus variant IIIA (VEE IIIA). Novel attenuating mutations of WEE and VEE IE and their uses are described. Also disclosed are attenuated chimearic alphaviruses and their uses.
    Type: Grant
    Filed: December 16, 1997
    Date of Patent: July 17, 2001
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Michael D. Parker, Jonathan F. Smith, Bruce J. Crise, Mark Steven Oberste, Shannon M. Schmura