Abstract: Luer lock connectors are provided that include an inner core of a hard material, the inner core sized and shaped to mate with an inner portion of an opposing luer lock connector, an outer layer of a soft material disposed on an outer surface of the inner core, and a plurality of grip features disposed on an outer surface of the outer layer, wherein the plurality of grip features are configured to provide a slip resistant grip surface. Infusion sets and infusion set luer lock connectors are also provided.