Abstract: The invention relates to compounds of formula (I), and related aspects.

Abstract: The invention relates to compounds of formula (I), and related aspects.

Abstract: The invention relates to compounds of formula (I), and related aspects.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between 0 ?s and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between 0 ?s and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between 0 ?s and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between 0 ?s and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between O?s and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between 0 ?s and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between Ops and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: Two biomarkers are provided for obstructive apnea. A first biomarker determines amplitude and timing of inspiratory efforts from a bioelectric signal. The respiratory rate is compared with a normal pre-detection rate, and the amplitude of the effort is compared with a normal amplitude. The obstructive apnea is likely present if a series of inspiratory efforts are above a normal amplitude and with increasing amplitude, but at a normal rate. A second biomarker determines heart rate and respiratory rate. A normal lower threshold for heartbeat interval is established, and if subthreshold events occur (short RR intervals), a commencement time for each sequence of subthreshold events is compared for a respiratory rate-normalized window. If the number of subthreshold events exceeds a minimum for the window, obstructive apnea is likely present.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between 0 ?s and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: Two biomarkers are provided for obstructive apnea. A first biomarker determines amplitude and timing of inspiratory efforts from a bioelectric signal. The respiratory rate is compared with a normal pre-detection rate, and the amplitude of the effort is compared with a normal amplitude. The obstructive apnea is likely present if a series of inspiratory efforts are above a normal amplitude and with increasing amplitude, but at a normal rate. A second biomarker determines heart rate and respiratory rate. A normal lower threshold for heartbeat interval is established, and if subthreshold events occur (short RR intervals), a commencement time for each sequence of subthreshold events is compared for a respiratory rate-normalized window. If the number of subthreshold events exceeds a minimum for the window, obstructive apnea is likely present.

Abstract: A method for ablating tissue by applying at least one pulse train of pulsed-field energy. The method includes delivering a pulse train of energy having a predetermined frequency to cardiac tissue, the pulse train including at least 60 pulses, an inter-phase delay between O?s and 5 ?s, an inter-pulse delay of at least 5 ?s, and a pulse width of 5 ?s.

Abstract: The present disclosure relates to a system for prevention of sudden death that includes a wearable seizure detection device; a base unit; and a computer, the computer configured to receive input from the seizure detection device and trigger the base unit to release oxygen under a condition effective to enrich an environmental oxygen level and prevent sudden death when the input indicates a seizure. Also disclosed is a portable system for preventing sudden death, where the system includes an oronasal mask; a compressed oxygen cartridge, wherein the compressed oxygen cartridge is coupled to the oronasal mask; and a fastener, wherein the fastener is coupled to the oronasal mask, wherein the system releases oxygen upon activation under a condition effective to enrich an environmental oxygen level and prevent sudden death. Further disclosed are methods of preventing sudden death comprising enriching an environmental oxygen level for a subject using the systems described.

Abstract: Associating a user service with a telephony identifier. The user service is accessible by a user of a telephony device via an application on the telephony device. The telephony device is operable in a radio telephony network (RTN) and is contactable via the telephony identifier when operating in the RTN. Network equipment: communicates, between the network equipment and the application on the telephony device, first data comprising a communicated token; receives, from the telephony device, second data comprising a received token, wherein the second data is received from the telephony device via an RTN-native service; receives, from a network node in the RTN, the telephony identifier in control signalling associated with the RTN-native service; and based at least on correlating the received token with the communicated token, associates the received telephony identifier with the user service.

Abstract: A foldable golf trolley comprising a chassis; at least one electrically powered rear drive wheel; a wheel support arm mounted to the front of the chassis supporting a front wheel; a stabilizer arm mounted to the rear of the chassis supporting a stabilizer wheel; a main support mounted to the chassis and a handle mounted to the main support; wherein the main support, the wheel support arm and the stabilizer arm are rotatably mounted to the chassis and movable between an operative configuration and a folded configuration; and gears connecting the stabilizer arm and main support, wherein rotation of the main support between the operative configuration and the folded configuration cause rotation of the stabilizer arm between the operative configuration and the folded configuration.

Abstract: Associating a user service with a telephony identifier. The user service is accessible by a user of a telephony device via an application on the telephony device. The telephony device is operable in a radio telephony network (RTN) and is contactable via the telephony identifier when operating in the RTN. Network equipment: communicates, between the network equipment and the application on the telephony device, first data comprising a communicated token; receives, from the telephony device, second data comprising a received token, wherein the second data is received from the telephony device via an RTN-native service; receives, from a network node in the RTN, the telephony identifier in control signalling associated with the RTN-native service; and based at least on correlating the received token with the communicated token, associates the received telephony identifier with the user service.

Abstract: A method of surgical dissection of tissue with a dissector comprising: an elongate shaft comprising a proximal portion and a distal portion, wherein the distal portion comprises a plurality of segments that articulate with respect to one another and the plurality of segments includes a distal segment having a distal end; and a handle attached to the proximal portion of the shaft, wherein the handle comprises controls for articulating the plurality of segments of the distal portion of the shaft with respect to one another, comprising the steps of: positioning the distal end of the dissector in a body; advancing the distal end through the body to dissect tissue; and simultaneously articulating the plurality of segments with respect to one another. A method of surgical dissection of tissue and guiding a second device to a desired physiological location with a first device.